Inhibiting nuclear factor kappa B improves heart function in a mouse model of Duchenne muscular dystrophy

Researchers have uncovered an unexpected mechanism that underlies cardiomyopathy (heart failure) in Duchenne muscular dystrophy (DMD). They report that nuclear factor kappa B down-regulates calcium genes, contributing to cardiomyopathy in DMD. Furthermore, data from a mouse model show cardiomyocyte ablation of NF-kappaB rescues cardiac function.

from Women's Health News -- ScienceDaily https://ift.tt/2LIuhPC

Inhibiting nuclear factor kappa B improves heart function in a mouse model of Duchenne muscular dystrophy

Researchers have uncovered an unexpected mechanism that underlies cardiomyopathy (heart failure) in Duchenne muscular dystrophy (DMD). They report that nuclear factor kappa B down-regulates calcium genes, contributing to cardiomyopathy in DMD. Furthermore, data from a mouse model show cardiomyocyte ablation of NF-kappaB rescues cardiac function.

from Women's Health News -- ScienceDaily https://ift.tt/2LIuhPC

Mechanism of Marburg virus sexual transmission identified in nonhuman primates

New research elucidates the mechanism of sexual transmission of filoviruses, which have been shown to persist in the testes and other immune privileged sites. Sexual transmission of filoviruses was first reported in 1968 after an outbreak of Marburg virus disease and recently caused flare-ups of Ebola virus disease in the 2013-2016 outbreak. The team found that Marburg virus persists in seminiferous tubules and that Sertoli cells are the reservoir for the virus.

from Sexual Health News -- ScienceDaily https://ift.tt/2C3uMV0
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A master switch controls aggressive breast cancer

Researchers have identified a master switch that appears to control the dynamic behavior of tumor cells that makes some aggressive cancers so difficult to treat. The gene Sox10 directly controls the growth and invasion of a significant fraction of hard-to-treat triple-negative breast cancers.

from Breast Cancer News -- ScienceDaily https://ift.tt/2N5ttcj

Novel role of protein in important pathways that lead to cancer malignancy

Researchers have revealed for the first time that a specific protein, the fatty acid-binding protein 5 (FABP5), plays a critical role in the development and metastasis of highly aggressive prostate and breast cancer cells. They point out that a better understanding of the molecular pathways of specific cancers is a step in the direction of finding more effective therapeutic targets.

from Breast Cancer News -- ScienceDaily https://ift.tt/2wyoQNX

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First indicators of prognosis for the most aggressive breast cancer

Researchers report a successful classification of triple breast cancer patients, which for the first time discriminates those who can be cured from those who might suffer a relapse. It also identifies new pharmacological targets, and indicates that in patients with these targets, combined treatments with existing drugs could be effective.

from Breast Cancer News -- ScienceDaily https://ift.tt/2MWNgeb

New way to break cancer's vicious cycle

This study reveals how some tumors fuel their own growth and how stopping this vicious cycle could lead to new treatments.

from Breast Cancer News -- ScienceDaily https://ift.tt/2wwZwaL

Chemotherapy may lead to early menopause in young women with lung cancer

A new study suggests chemotherapy may cause acute amenorrhea leading to early menopause in women with lung cancer. The study is the first to comment on amenorrhea rates in women younger than 50, concluding that women with lung cancer who desire future fertility should be educated about risks and options before starting treatment.

from Women's Health News -- ScienceDaily https://ift.tt/2olbNeI

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