Why colorectal cancer breaks the immune system’s rules

Colorectal cancer has long baffled scientists because, unlike most tumors, patients often do better when their cancers are packed with immune-suppressing regulatory T cells. New research finally explains why. Scientists discovered that these T cells aren’t all the same: one subtype actually helps keep tumors in check, while another shields cancer from immune attack. The balance between these “good” and “bad” cells can determine whether a tumor grows or shrinks.

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Why colorectal cancer breaks the immune system’s rules

Colorectal cancer has long baffled scientists because, unlike most tumors, patients often do better when their cancers are packed with immune-suppressing regulatory T cells. New research finally explains why. Scientists discovered that these T cells aren’t all the same: one subtype actually helps keep tumors in check, while another shields cancer from immune attack. The balance between these “good” and “bad” cells can determine whether a tumor grows or shrinks.

from Women's Health News -- ScienceDaily https://ift.tt/CadqI5n

New nasal vaccine shows strong protection against H5N1 bird flu

As bird flu continues to circulate in animals and spill over into humans, researchers are racing to stop it before it adapts to spread widely between people. A new nasal spray vaccine showed strong protection against H5N1 in animal tests, outperforming traditional flu shots. Because it targets the nose and lungs, it may prevent infection at the earliest stage.

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Why heart disease risk in type 2 diabetes looks different for men and women

Scientists are digging into why heart disease risk in type 2 diabetes differs between men and women—and sex hormones may be part of the story. In a large Johns Hopkins study, men with higher testosterone had lower heart disease risk, while rising estradiol levels were linked to higher risk. These hormone effects were not seen in women. The results point toward more personalized approaches to heart disease prevention in diabetes.

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Scientists find hidden pathways pancreatic cancer uses to spread

Researchers have discovered how pancreatic cancer reprograms its surroundings to spread quickly and stealthily. By using a protein called periostin, the tumor remodels nearby tissue and invades nerves, which helps cancer cells travel and form metastases. This process also creates a tough, fibrous barrier that makes treatments less effective. Targeting periostin could help stop this invasion before it starts.

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A Trojan horse cancer therapy shows stunning results

Scientists at Mount Sinai have unveiled a bold new way to fight metastatic cancer by turning the tumor’s own defenses against it. Instead of attacking cancer cells head-on, the experimental immunotherapy targets macrophages—immune cells that tumors hijack to shield themselves from attack. By eliminating or reprogramming these “bodyguards,” the treatment cracks open the tumor’s protective barrier and allows the immune system to flood in and destroy the cancer.

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A Trojan horse cancer therapy shows stunning results

Scientists at Mount Sinai have unveiled a bold new way to fight metastatic cancer by turning the tumor’s own defenses against it. Instead of attacking cancer cells head-on, the experimental immunotherapy targets macrophages—immune cells that tumors hijack to shield themselves from attack. By eliminating or reprogramming these “bodyguards,” the treatment cracks open the tumor’s protective barrier and allows the immune system to flood in and destroy the cancer.

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Dermatologists say collagen supplements aren’t the skin fix people expect

Collagen pills sound like a shortcut to younger skin, but solid evidence doesn’t back them up. Higher-quality studies show little benefit, and your body doesn’t absorb collagen in the way ads suggest. Some supplements may even pose safety concerns and lack proper testing. Experts recommend focusing on proven habits like sunscreen, retinoids, and a nutrient-rich diet instead.

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Brain cancer may begin years before doctors can see it

Scientists in South Korea have discovered that one of the most common malignant brain tumors in young adults may begin years before a tumor can be seen. IDH-mutant glioma, long treated by removing visible tumor tissue, actually starts when normal-looking brain cells quietly acquire a cancer-linked mutation and spread through the brain’s cortex. Using advanced genetic mapping and animal models, researchers traced the cancer’s true origin to glial progenitor cells that appear healthy at first.

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Scientists turn tumor immune cells into cancer killers

Scientists at KAIST have found a way to turn a tumor’s own immune cells into powerful cancer fighters—right inside the body. Tumors are packed with macrophages, immune cells that should attack cancer but are usually silenced by the tumor environment. By injecting a specially designed drug directly into tumors, researchers were able to “reprogram” these dormant cells to recognize and destroy cancer.

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