MIT scientists find a hidden cancer risk of the keto diet

A ketogenic diet increased small-intestinal tumors in cancer-prone mice while reducing tumors in the colon, revealing a strikingly different response within neighboring parts of the gut. Researchers traced the increased risk not to ketones, but to the way intestinal stem cells processed the diet’s high levels of fat. That fat-burning activity pushed the cells to multiply more rapidly, potentially raising the chance of cancerous changes.

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Cancer-fighting t cells burn out. Scientists may have found a fix

Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that can push T cells to burn through their energy while producing cancer-killing proteins. In animal and laboratory studies, blocking MEK helped the cells conserve energy, survive longer, and remain active even in the harsh environment around tumors.

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Vitamin D drug may help crack pancreatic cancer’s protective shield

A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D receptor.

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Alzheimer’s risk gene APOE4 may have a reversible weakness

The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

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Scientists say house cats could help unlock better cancer treatments for humans

Scientists have mapped the genetics of cat cancer on an unprecedented scale and found surprising similarities with tumors in humans. The findings could help bring precision cancer treatments to cats while also revealing new clues about how human cancers develop and respond to drugs.

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This new drug could break cancer’s resistance to treatment

A new experimental drug called CS18 may help break through cancer drug resistance by disabling several of the defenses tumors use to survive treatment. It strengthened existing therapies, restored drug sensitivity in resistant lung cancer cells, and slowed tumor growth in animal models.

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This emerging treatment could help people avoid knee replacement surgery

A minimally invasive procedure called genicular artery embolization could offer a new middle ground between conservative treatments and knee replacement for osteoarthritis. By blocking tiny blood vessels associated with inflammation, GAE can significantly reduce pain, with some patients reporting little or no pain afterward. Studies suggest the benefits may last two to four years in people who respond well.

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Scientists create a needle-thin brain implant that can do three jobs at once

A new needle-thin brain implant can record neural activity, deliver drugs, and stimulate multiple brain regions using a single flexible fiber. Successful tests in mice suggest it could give scientists a more precise, less invasive way to study the brain and may eventually help treat neurological disorders such as epilepsy.

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Millions take calcium and vitamin D for bone health. A major review finds little benefit

A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.

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Scientists discover cells that cheat death and rebuild damaged tissue

Scientists discovered a population of cells that can start the process of programmed cell death, survive it, and then help rapidly rebuild damaged tissue. Their descendants become far more resistant to future damage, revealing a mechanism that could improve healing but may also help cancers return after treatment.

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