Why colorectal cancer breaks the immune system’s rules

Colorectal cancer has long baffled scientists because, unlike most tumors, patients often do better when their cancers are packed with immune-suppressing regulatory T cells. New research finally explains why. Scientists discovered that these T cells aren’t all the same: one subtype actually helps keep tumors in check, while another shields cancer from immune attack. The balance between these “good” and “bad” cells can determine whether a tumor grows or shrinks.

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A Trojan horse cancer therapy shows stunning results

Scientists at Mount Sinai have unveiled a bold new way to fight metastatic cancer by turning the tumor’s own defenses against it. Instead of attacking cancer cells head-on, the experimental immunotherapy targets macrophages—immune cells that tumors hijack to shield themselves from attack. By eliminating or reprogramming these “bodyguards,” the treatment cracks open the tumor’s protective barrier and allows the immune system to flood in and destroy the cancer.

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A common painkiller may be quietly changing cancer risk

Ibuprofen may be doing more than easing aches and pains—it could also help reduce the risk of some cancers. Studies have linked regular use to lower rates of endometrial and bowel cancer, likely because the drug dampens inflammation that fuels tumor growth. Researchers have even found it can interfere with genes cancer cells rely on to survive. Still, experts warn that long-term use carries risks and shouldn’t replace proven prevention strategies.

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A smarter way to screen for breast cancer is emerging

A groundbreaking study shows that breast cancer screening works better when it’s personalized. Instead of annual mammograms for all, women were screened based on genetics, health history, and lifestyle factors. This approach reduced advanced cancers without increasing risk for those screened less often. Most women preferred the personalized model, hinting at a major shift in future screening guidelines.

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Scientists find 15 gut bacteria that may drive heart disease

Scientists in Seoul have uncovered 15 gut bacterial species linked to coronary artery disease, showing that microbes can influence heart health far beyond digestion. Their findings reveal how shifts in gut microbial function — including inflammation, loss of protective species, and overactive metabolic pathways — may drive disease progression. Intriguingly, even “good” bacteria like Faecalibacterium prausnitzii and Akkermansia muciniphila can become harmful under certain conditions.

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Doctors just found a way to slow one of the deadliest prostate cancers

A powerful new drug combination—niraparib added to standard prostate cancer therapy—has been shown to significantly delay disease progression in men with specific DNA repair gene mutations. In the large AMPLITUDE trial, patients receiving the combo lived longer without symptoms worsening and saw nearly a 50% risk reduction in BRCA-mutated cases. While side effects like anemia were more common, the results mark a major step toward precision medicine for prostate cancer.

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Rogue DNA rings may be the secret spark driving deadly brain cancer

Rogue DNA rings known as ecDNA may hold the key to cracking glioblastoma’s deadly resilience. Emerging before tumors even form, they could offer scientists a crucial early-warning system and a chance to intervene before the disease becomes untreatable.

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Scientists discover how to wipe out breast cancer’s hidden cells

Scientists at the University of Pennsylvania have shown for the first time that it’s possible to detect dormant cancer cells in breast cancer survivors and eliminate them with repurposed drugs, potentially preventing recurrence. In a clinical trial, existing medications cleared these hidden cells in most participants, leading to survival rates above 90%. The findings open a new era of proactive treatment against breast cancer’s lingering threat, offering hope to survivors haunted by the fear of relapse.

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Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

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Unlocking the secrets of cancer metastasis: study provides new insights, potential therapeutic opportunities

Metastasis remains the primary challenge to reducing cancer deaths worldwide. A study is providing insights that researchers say point to therapeutic opportunities.

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Scientists develop scans that light-up aggressive cancer tumors for better treatment

Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer.

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South African study identifies two new breast cancer genes in black women

South African scientists have identified two new breast cancer genes -- RAB27A and USP22 -- in Black women, marking the first GWAS of its kind on the continent. This breakthrough highlights the need for Africa-centred genomic research and tools to improve cancer risk prediction and treatment.

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New approach to treating aggressive breast cancers shows significant improvement in survival

A new treatment approach significantly improves survival rates for patients with aggressive, inherited breast cancers, according to researchers. In a trial where cancers were treated with chemotherapy followed by a targeted cancer drug before surgery, 100% of patients survived the critical three-year period post-surgery.

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Studies point to redlining as a 'perfect storm' for breast cancer

New research indicates that while the residential segregation policy was outlawed decades ago, it still impacts women's health today.

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Incidence rates of some cancer types have risen in people under age 50

Researchers have completed a comprehensive analysis of cancer statistics for different age groups in the United States and found that from 2010 through 2019, the incidence of 14 cancer types increased among people under age 50.

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Incidence of several early-onset cancers increased between 2010 and 2019

In the United States, breast, colorectal, endometrial, pancreatic, and kidney cancers are becoming increasingly common among people under age 50, according to a new study.

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Removing ovaries and fallopian tubes linked to lower risk of early death among breast cancer patients with BRCA cancer genes

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer. Now, researchers have shown that this procedure -- known as bilateral salpingo-oophorectomy (BSO) -- is associated with a substantial reduction in the risk of early death among these women, without any serious side-effects.

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AI-human task-sharing could cut mammography screening costs by up to 30%

The most effective way to harness the power of artificial intelligence when screening for breast cancer may be through collaboration with human radiologists -- not by wholesale replacing them, says new research.

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AI could help improve early detection of interval breast cancers

A new study suggests that artificial intelligence (AI) could help detect interval breast cancers before they become more advanced and harder to treat.

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Drug combination reduces breast cancer risk and improves metabolic health in rats

Researchers investigated the combined effects of bazedoxifene and conjugated estrogens in rat models as an alternative to tamoxifen.

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