South African study identifies two new breast cancer genes in black women

South African scientists have identified two new breast cancer genes -- RAB27A and USP22 -- in Black women, marking the first GWAS of its kind on the continent. This breakthrough highlights the need for Africa-centred genomic research and tools to improve cancer risk prediction and treatment.

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Incidence rates of some cancer types have risen in people under age 50

Researchers have completed a comprehensive analysis of cancer statistics for different age groups in the United States and found that from 2010 through 2019, the incidence of 14 cancer types increased among people under age 50.

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Incidence of several early-onset cancers increased between 2010 and 2019

In the United States, breast, colorectal, endometrial, pancreatic, and kidney cancers are becoming increasingly common among people under age 50, according to a new study.

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Removing ovaries and fallopian tubes linked to lower risk of early death among breast cancer patients with BRCA cancer genes

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer. Now, researchers have shown that this procedure -- known as bilateral salpingo-oophorectomy (BSO) -- is associated with a substantial reduction in the risk of early death among these women, without any serious side-effects.

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Low iron could cause brain fog during menopause transition

New research sheds light on an understudied area of science: iron levels in the blood and their relationship to cognitive performance in women transitioning into menopause. The findings are good news for women experiencing brain fog and other symptoms.

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Breast cancer mortality in women ages 20-49 significantly dropped between 2010 and 2020

Breast cancer deaths among women ages 20-49 declined significantly between 2010 and 2020, according to a new study.

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New machine algorithm could identify cardiovascular risk at the click of a button

An automated machine learning program has been able to identify potential cardiovascular incidents or fall and fracture risks based on bone density scans taken during routine clinical testing.

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Can hormone therapy improve heart health in menopausal women?

Oral hormone therapy may benefit heart health in menopausal women. A new analysis of data from the Women's Health Initiative found that estrogen-based oral hormone therapy had a long-term beneficial effect on biomarkers of cardiovascular health, including cholesterol.

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Telehealth might be a good option for women with incontinence

Women who experience urinary incontinence after giving birth may get just as much relief from telehealth as they do from physical therapy, a new study has found.

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Menopause at an early age can exacerbate cognitive decline

Why does dementia affect more women than men? To help solve this mystery, researchers uncovered a new risk factor: age of menopause onset.

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Researchers report association between urinary incontinence, cardiovascular disease

Researchers report an association between urinary incontinence and cardiovascular disease risk in women. The researcher recommend women should be checked regularly for urinary incontinence.

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Are high support bras bad for the back?

Researchers uncover how over-reducing breast motion in bras could increase back pain during exercise.

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Running on empty: Poor nutrition increases injury risk for female athletes

Proper nutrition is crucial for enhancing athletic performance, supporting recovery and overall health. Now, a new study reveals that proper nutrition is also key to reducing risk of injury, especially for females.

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Discovery of mitochondrial protein opens path to therapeutic advances for heart and Alzheimer's disease

Calcium transport into and out of mitochondria -- the powerhouses of cells -- is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses, cells rely on a protein known as the mitochondrial sodium-calcium exchanger, or NCLX. Now, in new research, scientists have discovered a novel regulator of NCLX activity, a protein called TMEM65, which helps move calcium out of mitochondria, protecting against harmful calcium overload.

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Estrogen and progesterone stimulate the body to make opioids

Female hormones can suppress pain by making immune cells near the spinal cord produce opioids, a new study has found. This stops pain signals before they get to the brain. The discovery could help with developing new treatments for chronic pain. It may also explain why some painkillers work better for women than men and why postmenopausal women experience more pain.

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Omega-6 fatty acid promotes the growth of an aggressive type of breast cancer, study finds

Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat 'triple negative' breast cancer subtype, according to a preclinical study. The discovery could lead to new dietary and pharmaceutical strategies against breast and other cancers.

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How a Y chromosome gene may shape the course of heart valve disease

Researchers have shed new light on how a type of heart valve disease -- aortic valve stenosis -- progresses differently in males and females.

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Vaccine may improve breast cancer treatment outcomes

Researchers have discovered a promising new vaccine strategy for treating a specific type of breast cancer. The innovative approach targets human epidermal growth factor receptor 2-positive, estrogen receptor-negative (HER2-positive, ER-negative) breast cancer and has shown encouraging results in a recent pilot study. The study combined the HER2-targeting dendritic cell vaccines with standard chemotherapy, demonstrating both safety and positive response rates.

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Slow, silent 'scream' of epithelial cells detected for first time

It has long been thought that only nerve and heart cells use electric impulses to communicate, while epithelial cells -- which compose the linings of our skin, organs and body cavities -- are mute, serving mostly as protective barriers that can absorb and secrete various substances. But researchers have now upended the status quo by showing that epithelial cells do indeed 'talk' to each other, albeit with slow electrical signals.

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Oxytocin system of breastfeeding affected in mothers with postnatal depression

The oxytocin system -- which helps release breast milk and strengthens the bond between mother and baby -- may be affected during breastfeeding in mothers experiencing postnatal depression.

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