How breast cancer arises

Researchers trace the origin of certain breast cancers to genomic reshuffling -- rearrangement of chromosomes -- that activates cancer genes and ignites disease. The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development. The study shows the sex hormone estrogen -- thus far thought to be only a fuel for breast cancer growth -- can directly cause tumor-driving genomic rearrangements.

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Gamma delta T cells can fight aggressive breast cancer

Researchers discover a mechanism by which cancer cells escape the immune system.

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Is bone health linked to brain health?

People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. The study does not prove that low bone density causes dementia. It only shows an association.

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Disproportionate percentage of females with unexplained infertility have gene variants known to cause heart problems, cancer

About 17% of women with unexplained infertility also have gene variants known to cause disease, from common conditions like heart disease to rare problems like ALS, researchers report.

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Scientists discover a new way to help prevent breast cancer 'time bomb'

Scientists have discovered why breast cancer cells that have spread to the lungs may 'wake up' following years of sleep -- forming incurable secondary tumors. Their research reveals the mechanism that triggers this breast cancer 'time bomb' -- and suggests a strategy to defuse it.

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Migraines during menstruation: Low estrogen levels paired with higher CGRP levels may jump start migraine

As estrogen levels fluctuate, a new study has found for female participants with migraine, their levels of the protein calcitonin gene-related peptide (CGRP) that plays a key role in starting the migraine process also fluctuate.

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Predicting two common heart conditions

Two novel research studies move the needle on predicting two important heart conditions -- sudden cardiac arrest, which is often fatal, and increased coronary artery calcium, a marker of coronary artery disease that can lead to a heart attack.

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Body Dissatisfaction Can Lead to Eating Disorders at Any Age

Eating disorders are stereotypically associated with adolescents and young adults. Growing evidence, however, suggests that these conditions can occur at any time during a woman's lifespan, including at midlife. A new study finds that body dissatisfaction is a primary cause of eating disorders, especially during perimenopause.

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Cystic fibrosis drug could help treat pneumonia

Pathogens such as SARS-CoV-2 and pneumococcus can cause severe pneumonia. If the airways then fill with fluid, the patient risks developing acute respiratory distress syndrome. Researchers have now discovered the molecular mechanisms that trigger fluid accumulation in the lungs. This also led them to discover a potential new therapy: A cystic fibrosis drug proved effective in their laboratory experiments, raising hope that this could be used to treat pneumonia regardless of the pathogen that caused it.

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High-energy X-rays leave a trace of destruction in bone collagen

A team of medical researchers has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II. With a combination of microscopy techniques, the scientists could document the destruction of collagen fibers induced by electrons emitted from the mineral crystals. X-ray methods might impact bone samples when measured for a long time they conclude.

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High doses of statins increase osteoporosis risk, shows study in animals

An animal experiment demonstrates what big data analysis previously indicated: high doses of statins likely increase osteoporosis risk.

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Subcutaneous fat emerges as a protector of females' brains

Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report.

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Who is more prone to recurrent UTIs? Bladder bacteria may be key

Researchers have identified specific bacteria in the bladder that may indicate which postmenopausal women are more susceptible to recurrent urinary tract infections (UTIs), and they found that estrogen may play a role in reducing that susceptibility.

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Estrogen may offer protection against delirium

Delirium is common among women with urinary tract infections (UTIs) -- especially those who have experienced menopause. Investigators, working with laboratory mice, have been able to prevent symptoms of the condition with estrogen, which is commonly used for hormone replacement therapy.

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How women can reduce the risk of hip fracture

Increasing intake of protein and drinking regular cups of tea or coffee is a way women could reduce their risk of suffering a hip fracture, according to new research. Food scientists have found that for women, a 25g a day increase in protein was associated with, on average, a 14% reduction in their risk of hip fracture. In a surprise twist, they also discovered that every additional cup of tea or coffee they drank was linked with a 4% reduction in risk.

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Birth choices after previous cesarean and risk of pelvic floor surgery

Vaginal birth after a previous cesarean section is associated with an increased risk of pelvic floor surgery compared with planning another cesarean, according to a new study. The findings provide useful information to help women who have had a previous cesarean section when planning how to give birth in their next pregnancy.

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Breast cancer survivorship doubles

A study shows there are 2.5 times as many breast cancer survivors in Canada today as there were in 2007 -- a success story that brings some new health challenges.

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Anthropologists find new ways female bones are permanently altered after giving birth

Reproduction permanently alters females' bones in ways not previously known, a team of anthropologists has found. Its discovery, based on an analysis of primates, sheds new light on how giving birth can permanently change the body.

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Stem cell-derived organoids mimic human parathyroid tissue

Patient-derived parathyroid organoids (PTOs) could pave the way for future physiology studies and drug-screening applications, as shown in a new study.

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Researchers develop 'Goldilocks drug' to treat triple-negative breast cancer

Researchers have developed a drug that so specifically targets a deadly kind of breast cancer that there are little to no toxic side effects. Next, it will be tested in phase 1 clinical trials in humans.

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