A heat-sensitive calcium channel gets positive feedback

A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers excessive calcium release from the endoplasmic reticulum. Clarifying the mechanism by which calcium release is accelerated at an elevated temperature in patients with malignant hyperthermia may also provide important insight into how exertional heat stroke occurs under extreme environmental conditions.

from Women's Health News -- ScienceDaily https://ift.tt/onZP4V8

New model can predict best drug combinations for osteoporosis

Scientists have developed a new mathematical model that may help clinicians decide on the best combination of osteoporosis medications for patients and the order in which they should be taken.

from Women's Health News -- ScienceDaily https://ift.tt/cAeHnSU

Scientists identify novel molecular biomarkers in cells that spread a deadly form of breast cancer

Studying a deadly type of breast cancer called triple negative, scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors.

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Diets higher in calcium and potassium may help prevent recurrent symptomatic kidney stones

Kidney stones can cause not only excruciating pain but also are associated with chronic kidney disease, osteoporosis and cardiovascular disease. If you've experienced a kidney stone once, you have a 30% chance of having another kidney stone within five years.

from Women's Health News -- ScienceDaily https://ift.tt/fTWOK9e

Informing children of a mother's genetic cancer risk does not impact their health behaviors, study finds

Telling a child about their mother's risk of hereditary breast and ovarian cancer does not adversely influence the offspring's lifestyle or quality of life in the long term, according to a new study.

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Researchers develop liquid biopsy technique to help detect cancer in blood

Researchers have found a new way to track metastatic cancer cells in the body, which in the future could help identify cancer earlier and give patients more treatment options.

from Breast Cancer News -- ScienceDaily https://ift.tt/2fGrW7m

Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds

Inducing programmed cell death (PCD), such as apoptosis, is a widely used therapeutic option for the treatment of cancer. Unfortunately, many cancer cells become resistant to PCDs, and continue multiplying. In a new study, researchers have synthesized new complex-hybrid compounds named triptycene-peptide hybrids (TPHs), which successfully induced a kind of PCD known as paraptosis in Jurkat cells - -a type of lymphocytes. These paraptosis-inducing compounds may revolutionize cancer therapy in the future.

from Women's Health News -- ScienceDaily https://ift.tt/AhrQ8bP

Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds

Inducing programmed cell death (PCD), such as apoptosis, is a widely used therapeutic option for the treatment of cancer. Unfortunately, many cancer cells become resistant to PCDs, and continue multiplying. In a new study, researchers have synthesized new complex-hybrid compounds named triptycene-peptide hybrids (TPHs), which successfully induced a kind of PCD known as paraptosis in Jurkat cells - -a type of lymphocytes. These paraptosis-inducing compounds may revolutionize cancer therapy in the future.

from Women's Health News -- ScienceDaily https://ift.tt/AhrQ8bP

The effect of breast cancer screening is declining

A new research result questions whether the benefits of breast cancer screenings has gradually declined to a degree that it is too small in relation to the costs in the form of overdiagnosis and overtreatment.

from Women's Health News -- ScienceDaily https://ift.tt/K6Jn5yx

The effect of breast cancer screening is declining

A new research result questions whether the benefits of breast cancer screenings has gradually declined to a degree that it is too small in relation to the costs in the form of overdiagnosis and overtreatment.

from Breast Cancer News -- ScienceDaily https://ift.tt/K6Jn5yx