High cholesterol fuels cancer by fostering resistance to a form of cell death

A research team has identified how breast cancer cells use cholesterol to develop tolerance to stress, making them impervious to death as they migrate from the original tumor site.

from Women's Health News -- ScienceDaily https://ift.tt/3guK4DW

Prediction models may reduce false-positives in MRI breast cancer screening

Prediction models based on clinical characteristics and imaging findings may help reduce the false-positive rate in women with dense breasts who undergo supplemental breast cancer screening with MRI, according to a new study.

from Breast Cancer News -- ScienceDaily https://ift.tt/2W7hb9R

Mechanisms of resistance to drug for triple-negative breast cancer identified

Triple-negative breast cancer cells exposed to the antibody-drug conjugate sacituzumab govitecan may develop resistance to this powerful drug through alterations in both the target of the antibody and the target of the toxic payload. The findings illustrate how uncovering such mechanisms will critically inform strategies to overcome resistance to sacituzumab govitecan.

from Breast Cancer News -- ScienceDaily https://ift.tt/3mg7DE7

Prediction models may reduce false-positives in MRI breast cancer screening

Prediction models based on clinical characteristics and imaging findings may help reduce the false-positive rate in women with dense breasts who undergo supplemental breast cancer screening with MRI, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2W7hb9R

Mechanisms of resistance to drug for triple-negative breast cancer identified

Triple-negative breast cancer cells exposed to the antibody-drug conjugate sacituzumab govitecan may develop resistance to this powerful drug through alterations in both the target of the antibody and the target of the toxic payload. The findings illustrate how uncovering such mechanisms will critically inform strategies to overcome resistance to sacituzumab govitecan.

from Women's Health News -- ScienceDaily https://ift.tt/3mg7DE7

Prediction models may reduce false-positives in MRI breast cancer screening

Prediction models based on clinical characteristics and imaging findings may help reduce the false-positive rate in women with dense breasts who undergo supplemental breast cancer screening with MRI, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2W7hb9R

Mechanisms of resistance to drug for triple-negative breast cancer identified

Triple-negative breast cancer cells exposed to the antibody-drug conjugate sacituzumab govitecan may develop resistance to this powerful drug through alterations in both the target of the antibody and the target of the toxic payload. The findings illustrate how uncovering such mechanisms will critically inform strategies to overcome resistance to sacituzumab govitecan.

from Women's Health News -- ScienceDaily https://ift.tt/3mg7DE7

Researchers pinpoint how PARP inhibitors combat BRCA1 and BRCA2 tumor cells

PARP inhibitors, used to treat patients with cancer of the breast, ovaries, prostate and pancreas, work by inducing persistent DNA gaps in tumor cells with BRCA1 and BRCA2 mutations. The discovery offers the potential to monitor tumors for the development of resistance to PARP inhibitor therapy, and to identify drug combinations that could prevent drug resistance and improve the efficacy of cancer therapies.

from Breast Cancer News -- ScienceDaily https://ift.tt/3CVuVFw

Atomic nuclei and leptons: Milestone in the calculation of cross sections

A team has succeeded in computing how atomic nuclei of the Calcium element behave in collisions with electrons. Results agree very well with available experimental data. For the first time, a calculation based on a fundamental theory is capable of correctly describing experiments for a nucleus as heavy as Calcium. Of particular relevance is the potential that such calculations could have in the future to interpret neutrino experiments.

from Women's Health News -- ScienceDaily https://ift.tt/3s8kHfG

Atomic nuclei and leptons: Milestone in the calculation of cross sections

A team has succeeded in computing how atomic nuclei of the Calcium element behave in collisions with electrons. Results agree very well with available experimental data. For the first time, a calculation based on a fundamental theory is capable of correctly describing experiments for a nucleus as heavy as Calcium. Of particular relevance is the potential that such calculations could have in the future to interpret neutrino experiments.

from Women's Health News -- ScienceDaily https://ift.tt/3s8kHfG