Scientists help immune system find hidden cancer cells

Cancer cells are masters at avoiding detection, but a new system can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss.

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New method visualizes groups of neurons as they compute

Using a fluorescent probe that lights up when brain cells are electrically active, researchers found they can image the activity of many neurons at once, in mice brains. The technique could allow neuroscientists to analyze circuits within the brain and link them to specific behaviors.

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'Wild idea' opens possible new frontier for preventing ovarian cancer

A laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.

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Chlamydia in testicular tissue linked to male infertility

The potential impact of undiagnosed sexually transmitted chlamydia infection on men's fertility has been highlighted in a study, which for the first time found chlamydia in the testicular tissue biopsies of infertile men whose infertility had no identified cause.

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Insights on treatment and prognosis of male breast cancer

A recent analysis reveals that treatment of male breast cancer has evolved over the years. In addition, certain patient-, tumor-, and treatment-related factors are linked with better survival.

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Research maps key signaling pathways linking calcium entry and exit in activated T cells

Like entrance and exit doors on a building, a cell's outer surface has doors -- channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells possess unique sets of 'doors', including ones that specialize in calcium ion movement. Now, researchers describe a unique mechanism for coordinating these calcium entrance and exit 'doors' on T cells that helps them carry out their jobs and ensure normal immune function.

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How can ultrasonic brain stimulation cure brain diseases?

Scientists found a calcium channel expressed in astrocytes in the brain to be a highly sensitive target for LILFU-induced neuronal activity in the motor cortex, such as tail movement.

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Mapping normal breast development to better understand cancer

Breast cancer is one of the most prevalent cancers, and some forms rank among the most difficult to treat. Its various types and involvement of many different cells makes targeting such tumors difficult. Now, researchers have used a state-of-the-art technology to profile each cell during normal breast development in order to understand what goes wrong in cancer.

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Voltage gated calcium channels 'read' electric patterns in embryos to create cartilage and bone

Scientists have revealed how the electrical patterns formed within an embryo initiate a cascade of molecular changes that culminate in the development of cartilage and bone. Prior studies have shown these electrical patterns appear like blueprints of the tissues and organs that eventually take shape as the embryo matures. The new study demonstrates that voltage gated calcium channels 'read' the electrical pattern, setting off the expression of genes that guide differentiation to mature cells.

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Critical process for how breast cancer spreads in bones

Researchers have identified a pair of proteins believed to be critical for spreading, or metastasizing, breast cancer to bone.

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