Insights on treatment and prognosis of male breast cancer

A recent analysis reveals that treatment of male breast cancer has evolved over the years. In addition, certain patient-, tumor-, and treatment-related factors are linked with better survival.

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Research maps key signaling pathways linking calcium entry and exit in activated T cells

Like entrance and exit doors on a building, a cell's outer surface has doors -- channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells possess unique sets of 'doors', including ones that specialize in calcium ion movement. Now, researchers describe a unique mechanism for coordinating these calcium entrance and exit 'doors' on T cells that helps them carry out their jobs and ensure normal immune function.

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How can ultrasonic brain stimulation cure brain diseases?

Scientists found a calcium channel expressed in astrocytes in the brain to be a highly sensitive target for LILFU-induced neuronal activity in the motor cortex, such as tail movement.

from Women's Health News -- ScienceDaily https://ift.tt/30WnRnP

Mapping normal breast development to better understand cancer

Breast cancer is one of the most prevalent cancers, and some forms rank among the most difficult to treat. Its various types and involvement of many different cells makes targeting such tumors difficult. Now, researchers have used a state-of-the-art technology to profile each cell during normal breast development in order to understand what goes wrong in cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/31Z07AO

Voltage gated calcium channels 'read' electric patterns in embryos to create cartilage and bone

Scientists have revealed how the electrical patterns formed within an embryo initiate a cascade of molecular changes that culminate in the development of cartilage and bone. Prior studies have shown these electrical patterns appear like blueprints of the tissues and organs that eventually take shape as the embryo matures. The new study demonstrates that voltage gated calcium channels 'read' the electrical pattern, setting off the expression of genes that guide differentiation to mature cells.

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Critical process for how breast cancer spreads in bones

Researchers have identified a pair of proteins believed to be critical for spreading, or metastasizing, breast cancer to bone.

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New evolution-busting drug overcomes resistance in aggressive breast cancers

A new type of drug that blocks one of cancer's key evolutionary escape routes from chemotherapy could be used to treat aggressive breast cancers, a new study has shown.

from Breast Cancer News -- ScienceDaily https://ift.tt/2Ooni3x

Aggressive breast cancers store large amounts of energy, which enables it to spread

Researchers found that aggressive breast cancers store glycogen in very large amounts, offering an explanation of how cells can change their function to evade treatment, grow and spread. Targeting an enzyme involved in this process could potentially treat or prevent metastases.

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Early menopause predictor of heart disease

Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers.

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Scientists ID new targets to treat fibrosis, a feature of many chronic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term -- but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis -- which impacts several chronic diseases.

from Women's Health News -- ScienceDaily https://ift.tt/2Okd2sZ