New evolution-busting drug overcomes resistance in aggressive breast cancers

A new type of drug that blocks one of cancer's key evolutionary escape routes from chemotherapy could be used to treat aggressive breast cancers, a new study has shown.

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Aggressive breast cancers store large amounts of energy, which enables it to spread

Researchers found that aggressive breast cancers store glycogen in very large amounts, offering an explanation of how cells can change their function to evade treatment, grow and spread. Targeting an enzyme involved in this process could potentially treat or prevent metastases.

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Early menopause predictor of heart disease

Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers.

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Scientists ID new targets to treat fibrosis, a feature of many chronic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term -- but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis -- which impacts several chronic diseases.

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Early menopause predictor of heart disease

Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers.

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Laser therapy gains credibility as effective option for treating vaginal problems

Nearly 50% of menopausal women complain of vaginal dryness, itching, and burning, among other commonly reported menopause symptoms. Laser therapy is one of the newer techniques for addressing these problems. A new study suggests that it is as effective and safe as vaginal estrogen in improving sexual and urinary functionality.

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Decades-long drop in breast cancer death rate continues

A decades-long decline in the breast cancer death rate continues, but has begun to slow in recent years.

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Tenfold increase in number of adolescents on HIV treatment in South Africa since 2010, but many still untreated

A new study of more than 700,000 one to 19-year olds being treated for HIV infection suggests a ten-fold increase in the number of adolescents aged 15 to 19 receiving HIV treatment in South Africa.

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Immune therapy eliminates tumor cells in early triple negative breast cancer

Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to new results from the KEYNOTE-522 trial. Interim results from the study, which is the first phase III trial of immunotherapy in early breast cancer, also indicated an improvement in event-free survival.

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Breast cancer: New data on cohort with recurrence score 26-100 shows 93% cancer-free rate at 5 years

In the prospective TAILORx trial, 93% of women with hormone-sensitive, HER2-negative, axillary node-negative breast cancer and a high Recurrence Score 26-100 were estimated to be cancer-free at five years. This outcome was much better than expected with endocrine therapy alone. The finding adds to limited data on outcomes with a high RS of 26-100, treated with taxane and/or anthracycline-containing chemotherapy plus endocrine therapy. It adds to the body of evidence supporting use of the RS.

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