Immune therapy eliminates tumor cells in early triple negative breast cancer

Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to new results from the KEYNOTE-522 trial. Interim results from the study, which is the first phase III trial of immunotherapy in early breast cancer, also indicated an improvement in event-free survival.

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Breast cancer: New data on cohort with recurrence score 26-100 shows 93% cancer-free rate at 5 years

In the prospective TAILORx trial, 93% of women with hormone-sensitive, HER2-negative, axillary node-negative breast cancer and a high Recurrence Score 26-100 were estimated to be cancer-free at five years. This outcome was much better than expected with endocrine therapy alone. The finding adds to limited data on outcomes with a high RS of 26-100, treated with taxane and/or anthracycline-containing chemotherapy plus endocrine therapy. It adds to the body of evidence supporting use of the RS.

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Whole genome sequencing could enable personalized cancer treatment

Whole genome sequencing of tumour cells could help predict the prognosis of a patient's cancer and offer clues to identify the most effective treatment, suggests an international study.

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Inflammation amps up neurite growth, gene expression involved in heat, cold sensitivity

Inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal -- but not physical- sensations in mice.

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Menopausal night sweats linked with cognitive dysfunction

Experts frequently tout the value of a good night's sleep. However, a new study casts doubt on the value of sleep time suggesting that women who experience night sweats are more vulnerable to cognitive dysfunction as their sleep duration increases.

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Onion and garlic consumption may reduce breast cancer risk

In the first population-based study to examine the association between onion and garlic consumption and breast cancer in Puerto Rico, researchers found that women who ate sofrito more than once per day had a 67% decreased breast cancer risk.

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Mummy study: Heart disease was bigger issue for human ancestors than initially thought

A new imaging study of the mummified arteries of people who lived thousands of years ago revealed that their arteries were more clogged than originally thought, according to a proof-of-concept study.

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Mummy study: Heart disease was bigger issue for human ancestors than initially thought

A new imaging study of the mummified arteries of people who lived thousands of years ago revealed that their arteries were more clogged than originally thought, according to a proof-of-concept study.

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New vaccine prevents herpes in mice, guinea pigs

A novel vaccine protected almost all mice and guinea pigs exposed to a new herpes virus. This may lead to the vaccine being tested in human studies.

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New target regulating mitochondria during stress

Like an emergency response team that is called into action to save lives, stress response proteins in the heart are activated during a heart attack to help prevent cell death. As part of this process, researchers show for the first time that one of these specialized emergency responder proteins, known as MCUB, temporarily decreases harmful levels of calcium transport into mitochondria, the energy-generating batteries of cells.

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