Researchers develop novel computational approach for identifying synergistic drug combinations

Researchers have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases. The study highlights iDOMO's ability to identify synergistic drug combinations using gene expression data, outperforming existing methods.

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Data from all 50 states shows early onset breast cancer is on the rise in younger women: Does place of exposure matter?

Breast cancer incidence trends in U.S. women under 40 vary by geography and supports incorporating location information with established risk factors into risk prediction, improving the ability to identify groups of younger women at higher risk for early-onset breast cancer.

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Data from all 50 states shows early onset breast cancer is on the rise in younger women: Does place of exposure matter?

Breast cancer incidence trends in U.S. women under 40 vary by geography and supports incorporating location information with established risk factors into risk prediction, improving the ability to identify groups of younger women at higher risk for early-onset breast cancer.

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Nerves electrify stomach cancer, sparking growth and spread

Researchers have found that a cancer outside the brain makes electrical connections with the nervous system to fuel cancer growth and aid its spread.

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Speculum exams unnecessary for HPV screening

Researchers have demonstrated that self-sampling is just as effective as speculum-based testing for HPV detection.

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Sweet taste receptors in the heart: A new pathway for cardiac regulation

In a surprising discovery, scientists have found that the heart possesses 'sweet taste' receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can modulate the heartbeat. This research opens new avenues for understanding heart function and potentially for developing novel treatments for heart failure.

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Landmark atlas reveals how aging breast tissue shapes breast cancer risk

Aging is a privilege, but it also brings risks -- including an increased likelihood of developing age-related diseases including cancer. Researchers have now created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.

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Landmark atlas reveals how aging breast tissue shapes breast cancer risk

Aging is a privilege, but it also brings risks -- including an increased likelihood of developing age-related diseases including cancer. Researchers have now created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.

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Disordered eating and certain foods linked to higher risk for urinary incontinence in middle-aged women

Eating behavior is associated with symptoms of pelvic floor disorders in middle-aged women. For example, higher consumption of highly processed ready-made foods and fast food increased the risk for experiencing symptoms of stress and urgency urinary incontinence. Higher consumption of fruits and an overall higher quality diet decreased the risk for stress urinary incontinence.

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Innovative dual-target drug may lead to new investigational approach for breast cancer patients

Researchers discover new insights into how dual-target drug may supercharge cancer-fighting immune cells.

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Ovarian cancer discovery could turn failed treatment into lifesaver

Gut bacteria are to blame for the failure of immune checkpoint therapy for ovarian cancer, new research reveals.

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Disruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long noncoding RNA (lncRNA) 'XIST' could be an effective therapeutic strategy for treating aggressive breast cancer.

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Breast cancers broadly defined by their genome architecture

Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues.

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Breast cancers broadly defined by their genome architecture

Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues.

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Drug may counteract muscle loss and osteoporosis after rapid weight loss

Rapid weight loss affects muscle mass and can increase the risk of osteoporosis. But now there is good news for people taking weight loss medication who may be at risk. A new study indicates that the drug bimagrumab can counteract the side effects.

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From muscle to memory: New research uses clues from the body to understand signaling in the brain

New research shows that a network of subcellular structures similar to those responsible for propagating molecular signals that make muscles contract are also responsible for transmitting signals in the brain that may facilitate learning and memory.

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Fear of breast cancer recurrence: Impact and coping with being in a dark place

A new study of breast cancer survivors has found this psychosocial challenge impacts almost every important domain of their lives -- the emotional, behavioral, cognitive, relational and professional. A larger number of domains was affected, and they were affected more frequently in those with greater fear of recurrence. The majority of study participants indicated that they sought senses of purpose, belonging, control and connection with others.

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Later-onset menopause linked to healthier blood vessels, lower heart disease risk

New research shows that women who hit menopause later in life have healthier blood vessels and mitochondria and a different composition of metabolites in their blood than those who stop menstruating earlier. The study helps explain why late-onset menopause is linked to lower risk of heart attacks and strokes.

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Communication between body muscle and the brain influences fertility

A newly discovered line of communication between body muscle and the pituitary gland may play an unexpected role in female fertility, according to a new study. Researchers found that a protein produced in the muscles helps manage the release of a hormone made in the pea-sized gland attached to the base of the brain.

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How hungry fat cells could someday starve cancer to death

Liposuction and plastic surgery aren't often mentioned in the same breath as cancer. But they are the inspiration for a new approach to treating cancer that uses engineered fat cells to deprive tumors of nutrition. Researchers at UC San Francisco used the gene editing technology CRISPR to turn ordinary white fat cells into 'beige' fat cells, which voraciously consume calories to make heat.

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Inhibitor drugs to treat aggressive breast cancer identified

A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.

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