Why your vitamin D supplements might not be working

A randomized trial from Vanderbilt-Ingram Cancer Center reveals that magnesium may be the missing key to keeping vitamin D levels in balance. The study found that magnesium raised vitamin D in people who were deficient while dialing it down in those with overly high levels—suggesting a powerful regulating effect. This could help explain why vitamin D supplements don’t work the same way for everyone and why past studies linking vitamin D to cancer and heart disease have produced mixed results.

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Stanford scientists uncover why mRNA COVID vaccines can trigger heart inflammation

Stanford scientists have uncovered how mRNA COVID-19 vaccines can very rarely trigger heart inflammation in young men — and how that risk might be reduced. They found that the vaccines can spark a two-step immune reaction that floods the body with inflammatory signals, drawing aggressive immune cells into the heart and causing temporary injury.

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Cancer cells depend on a dangerous DNA repair trick

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone emergency fix that helps them survive. Some cancer cells rely heavily on this backup system, even though it makes their DNA more unstable. Blocking this process could expose a powerful new way to target tumors.

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MIT scientists strip cancer of its sugar shield

Scientists at MIT and Stanford have unveiled a promising new way to help the immune system recognize and attack cancer cells more effectively. Their strategy targets a hidden “off switch” that tumors use to stay invisible to immune defenses—special sugar molecules on the cancer cell surface that suppress immune activity. Early tests show it can supercharge immune responses and outperform current antibody therapies.

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Cannabis compounds show unexpected power against ovarian cancer

Scientists have discovered that key compounds from cannabis—CBD and THC—show surprisingly strong effects against ovarian cancer cells. Used together, they slow cell growth, reduce colony formation, and may even block the cancer’s ability to spread. Even more promising, the treatment caused minimal harm to healthy cells and appears to work by restoring a disrupted signaling pathway that fuels tumor growth.

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AI finds a hidden stress signal inside routine CT scans

Researchers used a deep learning AI model to uncover the first imaging-based biomarker of chronic stress by measuring adrenal gland volume on routine CT scans. This new metric, the Adrenal Volume Index, correlates strongly with cortisol levels, allostatic load, perceived stress, and even long-term cardiovascular outcomes, including heart failure risk.

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Tea may strengthen bones in older women while heavy coffee weakens them

A decade-long study of older women found that tea drinkers had slightly stronger bones, while moderate coffee drinking caused no harm. Heavy coffee intake—over five cups a day—was linked to lower bone density, especially in women who consumed more alcohol. Tea’s benefits may stem from catechins that support bone formation. The researchers say small daily habits could make a meaningful difference over time.

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Simple supplement mix shows remarkable results in brain cancer

New research is challenging one of medicine’s oldest assumptions: that cancer must be attacked to be cured. By treating glioblastoma patients with a simple combination of resveratrol and copper, the researchers found dramatic reductions in tumor aggressiveness, cancer biomarkers, immune checkpoints, and stem-cell–related markers—all without side effects. Their approach focuses on “healing” tumors by eliminating harmful cell-free chromatin particles released from dying cancer cells, which normally inflame and worsen the disease. The findings hint at a future where inexpensive nutraceuticals could transform cancer therapy.

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A routine shingles shot may offer powerful defense against dementia

A unique vaccine rollout in Wales gave researchers an accidental natural experiment that revealed a striking reduction in dementia among seniors who received the shingles vaccine. The protective effect held steady across multiple analyses and was even stronger in women. Evidence also suggests benefits for people who already have dementia, hinting at a therapeutic effect.

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Scientists discover hidden switch that helps cancer cells survive

Researchers have found a small but powerful switch inside breast cancer cells that helps them survive stressful conditions. When this switch flips, the cells activate protective programs that make them tougher and faster-growing. The finding reveals how tumors use stress to their benefit. It may open up new possibilities for therapies.

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New nasal nanodrops wipe out brain tumors in mice

A new nasal-delivered nanotherapy shows promise against aggressive glioblastoma tumors. By activating the STING immune pathway using gold-core spherical nucleic acids, researchers were able to reach the brain without invasive surgery. When paired with drugs that boost T-cell activity, the treatment eliminated tumors in mice and built long-lasting immunity. The results suggest a powerful new direction for brain cancer immunotherapy.

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Scientists reveal a hidden hormone switch for learning

Researchers uncovered how estrogen subtly reshapes learning by strengthening dopamine reward signals in the brain. Rats learned faster when estrogen levels were high and struggled when the hormone’s activity was blocked. The findings help explain how hormonal cycles influence cognitive performance and psychiatric symptoms. This connection offers a new path for understanding brain disorders tied to dopamine.

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Scientists reawaken exhausted T cells to supercharge cancer immunity

Researchers discovered a way to keep T cells from wearing out during the fight against cancer, and the approach could make immune-based treatments far more powerful. They found that tumors use a particular molecular signal to weaken T cells, and that interrupting this signal helps the cells stay active.

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Amazon scorpion venom shows stunning power against breast cancer

Scientists are turning venom, radioisotopes, engineered proteins, and AI into powerful new tools against cancer. From Amazonian scorpions yielding molecules that kill breast cancer cells as effectively as chemotherapy, to improved fibrin sealants and custom-grown bioactive factors, researchers are pushing biotechnology into uncharted territory. Parallel teams are advancing radiotheranostics that diagnose and destroy tumors with precision, while others forge experimental vaccines that train the immune system using hybrid dendritic cells.

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Scientists find 15 gut bacteria that may drive heart disease

Scientists in Seoul have uncovered 15 gut bacterial species linked to coronary artery disease, showing that microbes can influence heart health far beyond digestion. Their findings reveal how shifts in gut microbial function — including inflammation, loss of protective species, and overactive metabolic pathways — may drive disease progression. Intriguingly, even “good” bacteria like Faecalibacterium prausnitzii and Akkermansia muciniphila can become harmful under certain conditions.

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Tiny implant wipes out bladder cancer in 82% of patients

TAR-200, a small drug-releasing implant, wiped out tumors in most patients with high-risk bladder cancer. Its slow, consistent release of chemotherapy proved far more effective than traditional short-term treatments. The therapy may replace bladder removal surgery for many and has earned FDA Priority Review due to its impressive results.

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Scientists turn body fat into bone to heal spinal fractures

Researchers in Osaka have found that stem cells from fat tissue can repair spinal fractures similar to those caused by osteoporosis. By turning these cells into bone-forming clusters and pairing them with a bone-rebuilding material, rats regained stronger, healthier spines. The approach could offer a safe, minimally invasive alternative for treating bone diseases in humans.

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Scientists discover COVID mRNA vaccines boost cancer survival

Researchers found that COVID-19 mRNA vaccines significantly increased survival in lung and skin cancer patients undergoing immunotherapy. The vaccine appears to prime the immune system in a powerful, nonspecific way, enhancing cancer treatment outcomes. If confirmed, the discovery could lead to a universal cancer vaccine and transform oncology care.

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Doctors just found a way to slow one of the deadliest prostate cancers

A powerful new drug combination—niraparib added to standard prostate cancer therapy—has been shown to significantly delay disease progression in men with specific DNA repair gene mutations. In the large AMPLITUDE trial, patients receiving the combo lived longer without symptoms worsening and saw nearly a 50% risk reduction in BRCA-mutated cases. While side effects like anemia were more common, the results mark a major step toward precision medicine for prostate cancer.

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Brain fog during menopause? Here’s what’s really going on

Menopause brings profound shifts not just in hormones but in the very structure of the brain. Scientists have found that gray matter in regions tied to memory and thinking can shrink, while white matter may show damage linked to blood flow issues. Yet there’s hope — evidence points to partial recovery and adaptive changes postmenopause.

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Cancer patients who got a COVID vaccine lived much longer

A groundbreaking study reveals that cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived dramatically longer than those who didn’t. Researchers from the University of Florida and MD Anderson Cancer Center discovered that the vaccine’s immune-activating properties may boost cancer-fighting responses, acting like a nonspecific “flare” that reawakens the immune system.

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How cutting lipids could starve breast cancer

Researchers found that triple-negative breast cancer cells are “addicted” to lipids, a feature tied to obesity. By studying mice, they discovered that high lipid levels alone accelerate tumor growth. Lowering these fats slowed cancer progression, suggesting that lipid-lowering treatments could help. The findings also caution against high-fat diets such as keto for patients with obesity.

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Scientists just debunked the calcium and dementia myth

A long-term Australian study found that calcium supplements do not raise dementia risk in older women, countering previous fears. The research followed more than 1,400 participants for nearly 15 years and revealed no harmful cognitive effects. Scientists say these results should reassure those using calcium to prevent osteoporosis, though more research is needed across broader populations.

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This common liver supplement could boost cancer treatment success

Salk Institute scientists discovered that bile acids in the liver can weaken immune cell function, making immunotherapy less effective against liver cancer. They pinpointed specific bile acids that suppress T cells and found that supplementing with UDCA reversed the effect, controlling tumor growth in mice. Since UDCA is already used for liver disease, it could quickly translate into clinical trials.

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They found the switch that makes the body attack cancer

Scientists have found a way to transform hard-to-treat tumors into targets for the immune system. Using two protein stimulators, they activated strong T-cell and B-cell responses and built immune structures inside tumors that improved survival and prevented recurrence. This approach could make existing immunotherapies and chemotherapies more effective and long-lasting.

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This new blood test can catch cancer 10 years early

Scientists at Mass General Brigham have created HPV-DeepSeek, a blood test that can detect HPV-linked head and neck cancers nearly a decade before diagnosis. By finding viral DNA in the bloodstream, the test achieved 99% sensitivity and specificity. This breakthrough could lead to earlier, less invasive treatments and significantly improve survival. A large NIH trial is underway to confirm the results.

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This experimental “super vaccine” stopped cancer cold in the lab

UMass Amherst researchers have developed a groundbreaking nanoparticle-based cancer vaccine that prevented melanoma, pancreatic, and triple-negative breast cancers in mice—with up to 88% remaining tumor-free. The vaccine triggers a multi-pathway immune response, producing powerful T-cell activation and long-term immune memory that stops both tumor growth and metastasis. By combining cancer-specific antigens with a lipid nanoparticle “super adjuvant,” it overcomes key challenges in cancer immunotherapy.

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New pill could finally control stubborn high blood pressure

A new pill called baxdrostat may offer hope for people whose blood pressure stays high even after taking standard medications. In a recent study, the drug lowered blood pressure and also seemed to protect the kidneys by reducing signs of damage. Doctors say this could help millions of people with chronic kidney disease, a condition that often makes blood pressure harder to control.

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Brain cancer that eats the skull stuns scientists

A new study shows glioblastoma isn’t confined to the brain—it erodes the skull and hijacks the immune system within skull marrow. The cancer opens channels that let inflammatory cells enter the brain, fueling its deadly progression. Even drugs meant to protect bones can make things worse, highlighting the need for therapies that target both brain and bone. The discovery reframes glioblastoma as a whole-body disease, not just a brain disorder.

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The vitamin D mistake weakening your immunity

Scientists discovered that vitamin D2 supplements can lower levels of vitamin D3, the form the body uses most effectively. Unlike D2, vitamin D3 enhances the immune system’s first line of defense against infections. This raises questions about which type of supplement should be prioritized.

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Miscarriages, down syndrome, and infertility all linked to this hidden DNA process

Human fertility hinges on a delicate molecular ballet that begins even before birth. UC Davis researchers have uncovered how special protein networks safeguard chromosomes as eggs and sperm form, ensuring genetic stability across generations. Using yeast as a model, they revealed how crossovers between chromosomes are protected for decades in female eggs, preventing errors that could lead to infertility, miscarriage, or conditions like Down syndrome.

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How dehydration secretly fuels anxiety and health problems

Not drinking enough water could intensify stress responses. Researchers found that under-hydrated individuals had cortisol levels more than 50% higher during stressful situations. Poor hydration didn’t make participants feel thirstier, but it did trigger biological signs of strain. Keeping a water bottle handy could help manage stress and safeguard health.

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Scientists discover microplastics deep inside human bones

Microplastics have been detected in human blood, brain tissue, and even bones, where they may weaken skeletal structure and accelerate cell aging. Recent studies suggest that these particles could worsen metabolic bone diseases like osteoporosis, a risk that’s especially concerning as fractures are projected to rise sharply in the coming decades.

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Rogue DNA rings may be the secret spark driving deadly brain cancer

Rogue DNA rings known as ecDNA may hold the key to cracking glioblastoma’s deadly resilience. Emerging before tumors even form, they could offer scientists a crucial early-warning system and a chance to intervene before the disease becomes untreatable.

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Blood test spots hidden mesothelioma that scans can’t see

New research suggests that immunotherapy given before and after surgery could help patients with diffuse pleural mesothelioma, one of the most challenging cancers to treat. A phase II clinical trial tested immunotherapy in resectable cases, with promising results presented at the World Conference on Lung Cancer.

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The sleep switch that builds muscle, burns fat, and boosts brainpower

UC Berkeley researchers mapped the brain circuits that control growth hormone during sleep, uncovering a feedback system where sleep fuels hormone release, and the hormone regulates wakefulness. The discovery helps explain links between poor sleep, obesity, diabetes, and cognitive decline, while opening new paths for treating sleep and metabolic disorders.

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Scientists may have found a way to strengthen bones for life

Scientists at Leipzig University have identified a little-known receptor, GPR133, as a key player in bone health. By stimulating this receptor with a new compound called AP503, they were able to boost bone strength in mice, even reversing osteoporosis-like conditions. The breakthrough highlights a promising path toward safer and more effective treatments for millions struggling with bone loss, while also hinting at broader benefits for aging populations.

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Scientists discover how to wipe out breast cancer’s hidden cells

Scientists at the University of Pennsylvania have shown for the first time that it’s possible to detect dormant cancer cells in breast cancer survivors and eliminate them with repurposed drugs, potentially preventing recurrence. In a clinical trial, existing medications cleared these hidden cells in most participants, leading to survival rates above 90%. The findings open a new era of proactive treatment against breast cancer’s lingering threat, offering hope to survivors haunted by the fear of relapse.

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Scientists discover how to wipe out breast cancer’s hidden cells

Scientists at the University of Pennsylvania have shown for the first time that it’s possible to detect dormant cancer cells in breast cancer survivors and eliminate them with repurposed drugs, potentially preventing recurrence. In a clinical trial, existing medications cleared these hidden cells in most participants, leading to survival rates above 90%. The findings open a new era of proactive treatment against breast cancer’s lingering threat, offering hope to survivors haunted by the fear of relapse.

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Common heart drug taken by millions found useless, possibly risky

Beta blockers, used for decades after heart attacks, provide no benefit for patients with preserved heart function, according to the REBOOT trial. The massive study also found women faced higher risks when taking the drug. Experts say the results will change heart treatment guidelines worldwide.

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Lithium deficiency may be the hidden spark behind Alzheimer’s

Harvard scientists have uncovered that lithium, a naturally occurring element in the brain, may be the missing piece in understanding Alzheimer’s. Their decade-long research shows that lithium depletion—caused by amyloid plaques binding to it—triggers early brain changes that lead to memory loss. By testing new lithium compounds that evade plaque capture, they reversed Alzheimer’s-like damage and restored memory in mice at doses far lower than those used in psychiatric treatments.

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The surprising reason x-rays can push arthritis patients toward surgery

Knee osteoarthritis is a major cause of pain and disability, but routine X-rays often do more harm than good. New research shows that being shown an X-ray can increase anxiety, make people fear exercise, and lead them to believe surgery is the only option, even when less invasive treatments could help. By focusing on clinical diagnosis instead, patients may avoid unnecessary scans, reduce health costs, and make better choices about their care.

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Scientists uncover sugar pathway driving aggressive childhood cancer

Scientists have uncovered a hidden weakness in one of the deadliest childhood cancers. The tumors, which spread quickly and are notoriously hard to treat, rely on a sugar-processing pathway to survive and grow. By blocking this pathway, researchers were able to slow down the cancer and make it more vulnerable to treatment. This breakthrough opens the door to new therapies for children and young adults facing a disease with very few options today.

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A new cancer vaccine just wiped out tumors in mice

A breakthrough mRNA cancer vaccine has shown the ability to supercharge the effects of immunotherapy in mice, sparking hope for a universal “off-the-shelf” treatment that could fight multiple cancers. Unlike traditional vaccines designed to target specific tumor proteins, this approach simply revs up the immune system as if it were fighting a virus. The results were dramatic—when paired with checkpoint inhibitors, tumors shrank, and in some cases, the vaccine alone wiped them out.

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Trojan horse bacteria sneak cancer-killing viruses into tumors

Scientists have engineered a groundbreaking cancer treatment that uses bacteria to smuggle viruses directly into tumors, bypassing the immune system and delivering a powerful one-two punch against cancer cells. The bacteria act like Trojan horses, carrying viral payloads to cancer’s core, where the virus can spread and destroy malignant cells. Built-in safety features ensure the virus can’t multiply outside the tumor, offering a promising pathway for safe, targeted therapy.

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Starving tumors makes cancer treatment work better

Pancreatic cancer cells are known for being hard to treat, partly because they change the environment around them to block drugs and immune cells. Scientists discovered that these tumors use a scavenging process—called macropinocytosis—to pull nutrients from nearby tissue and keep growing. By blocking this process in mice, researchers were able to change the tumor’s environment, making it softer, less dense, and easier for immune cells and therapies to reach.

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Perfectly timed cancer combo wipes out tumors by supercharging the immune system

Head and neck cancer, notoriously hard to treat, might have a new weakness—timing. Researchers discovered that syncing radiation and immunotherapy in just the right way can make tumors disappear in mice. By protecting the body’s immune system hubs, they’ve unlocked a potentially powerful method to fight aggressive cancers more effectively. Clinical trials are already underway, hinting at a new era in cancer treatment.

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Breakthrough lung cancer treatment supercharges immune cells with mitochondria

Scientists have found a way to supercharge lung cancer treatment by transplanting healthy mitochondria into tumors, which both boosts immune response and makes chemotherapy far more effective. By combining this novel method with cisplatin, researchers reversed harmful tumor metabolism and empowered immune cells to fight back, all without added toxicity.

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This vaccine uses dental floss instead of needles

Scientists have discovered that flossing between your teeth could one day help vaccinate you. By targeting a uniquely permeable gum tissue called the junctional epithelium, this new method stimulates immunity right where many infections enter: the mouth, nose, and lungs. Using dental floss on mice to apply a flu vaccine triggered a robust immune response—better than existing oral approaches and comparable to nasal vaccines, but without the risks. It even worked with mRNA and protein-based vaccines.

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This gut hormone could explain 40% of IBS-D cases—and lead to a cure

A mysterious gut hormone may be behind many cases of chronic diarrhea, especially in people with undiagnosed bile acid malabsorption, a condition often mistaken for irritable bowel syndrome. Researchers from the University of Cambridge identified that the hormone INSL5 spikes when bile acid reaches the colon, triggering intense diarrhea. Their discovery not only sheds light on the biological cause of symptoms but opens the door to a diagnostic blood test and new treatment options, including a surprising existing drug that blocks this hormone’s effects.

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Breakthrough: How radiation helps the immune system kill cancer

Radiation therapy, once thought of mainly as a local cancer treatment, is now showing power to awaken the immune system in surprising ways. Researchers discovered that combining radiation with immunotherapy can transform stubborn, unresponsive lung tumors into targets for immune attack—especially those considered “cold” and typically resistant. This happens through a rare and poorly understood effect where immune cells are activated systemically, not just at the radiation site. Patients whose tumors underwent this “warm-up” had significantly better outcomes, revealing a promising new strategy for fighting hard-to-treat cancers.

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Three-person DNA IVF stops inherited disease—eight healthy babies born in UK first

In a groundbreaking UK first, eight healthy babies have been born using an IVF technique that includes DNA from three people—two parents and a female donor. The process, known as pronuclear transfer, was designed to prevent the inheritance of devastating mitochondrial diseases passed down through the mother’s DNA. The early results are highly promising: all the babies are developing normally, and the disease-causing mutations are undetectable or present at levels too low to cause harm. For families once haunted by genetic risk, this science offers more than treatment—it offers transformation.

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Not just hot flashes: The hidden depression crisis in early menopause

Premature menopause isn t just a hormonal issue it s a deeply emotional one for many women. A new study reveals that almost 30% experience depression, and it s not just about hormone loss but also grief, identity, and support systems.

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Hormone therapy supercharges tirzepatide, unleashing major weight loss after menopause

Postmenopausal women struggling with weight loss may find a powerful solution by combining the diabetes drug tirzepatide with menopause hormone therapy. A Mayo Clinic study revealed that this dual treatment led to significantly greater weight loss than tirzepatide alone. Women using both treatments lost 17% of their body weight on average, compared to 14% in those not using hormone therapy—and nearly half achieved dramatic 20%+ weight loss.

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The fatal mutation that lets cancer outsmart the human immune system

Scientists at UC Davis discovered a small genetic difference that could explain why humans are more prone to certain cancers than our primate cousins. The change affects a protein used by immune cells to kill tumors—except in humans, it’s vulnerable to being shut down by an enzyme that tumors release. This flaw may be one reason treatments like CAR-T don’t work as well on solid tumors. The surprising twist? That mutation might have helped our brains grow larger over time. Now, researchers are exploring ways to block the enzyme and give our immune system its power back.

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Inside the tumor: AI cracks five hidden cell types to stop cancer’s comeback

A new AI tool, AAnet, has discovered five distinct cell types within tumors, offering a deeper look into cancer's inner diversity. This insight could transform how we treat cancer, enabling more personalized therapies that tackle every type of cell in a tumor.

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The pleasure prescription: Why more sex means less menopause pain

Keeping sex on the schedule may be its own menopause medicine: among 900 women aged 40-79, those active in the last three months reported far less dryness, pain, and irritation, while orgasm and overall satisfaction stayed rock-solid despite dips in desire and lubrication. The results hint that intimacy itself can curb genitourinary syndrome of menopause, a cluster of estrogen-related symptoms that erode quality of life.

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One shot to stop HIV: MIT's bold vaccine breakthrough

Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies. This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases. It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine.

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Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

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Unlocking the secrets of cancer metastasis: study provides new insights, potential therapeutic opportunities

Metastasis remains the primary challenge to reducing cancer deaths worldwide. A study is providing insights that researchers say point to therapeutic opportunities.

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Proteins and pathways involved in inflammation are associated with changes in bone mineral density over time

Researchers have found that proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time. The research, could potentially lead to the identification of biomarkers that would serve as early indicators of a person's risk for bone health issues later in life.

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Scientists develop scans that light-up aggressive cancer tumors for better treatment

Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer.

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Potential to prevent and treat a common type of inflammatory arthritis advanced by the identification of new genetic links

Researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. This crystalline arthritis is caused by calcium pyrophosphate (CPP) crystal deposition in joints. The findings of this novel study open up promising new avenues for targeted prevention and treatment of CPPD disease, which are currently lacking.

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An artificial protein that moves like something found in nature

Proteins catalyze life by changing shape when they interact with other molecules. The result is a muscle twitching, the perception of light, or a bit of energy extracted from food. The ability to engineer shapeshifting proteins opens new avenues for medicine, agriculture, and beyond.

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PREVENT equation accurately estimated 10-year CVD risk and those with calcium buildup

A new risk calculator accurately identified participants who had calcium buildup in their heart arteries and those who had a higher future heart attack risk, in an analysis of about 7,000 adults in New York City referred for heart disease screening.

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How molecules can 'remember' and contribute to memory and learning

Researchers have discovered how an ion channel in the brain's neurons has a kind of 'molecular memory', which contributes to the formation and preservation of lifelong memories. The researchers have identified a specific part of the ion channel at which new drugs for certain genetic diseases could be targeted.

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South African study identifies two new breast cancer genes in black women

South African scientists have identified two new breast cancer genes -- RAB27A and USP22 -- in Black women, marking the first GWAS of its kind on the continent. This breakthrough highlights the need for Africa-centred genomic research and tools to improve cancer risk prediction and treatment.

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South African study identifies two new breast cancer genes in black women

South African scientists have identified two new breast cancer genes -- RAB27A and USP22 -- in Black women, marking the first GWAS of its kind on the continent. This breakthrough highlights the need for Africa-centred genomic research and tools to improve cancer risk prediction and treatment.

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New approach to treating aggressive breast cancers shows significant improvement in survival

A new treatment approach significantly improves survival rates for patients with aggressive, inherited breast cancers, according to researchers. In a trial where cancers were treated with chemotherapy followed by a targeted cancer drug before surgery, 100% of patients survived the critical three-year period post-surgery.

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Studies point to redlining as a 'perfect storm' for breast cancer

New research indicates that while the residential segregation policy was outlawed decades ago, it still impacts women's health today.

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Incidence rates of some cancer types have risen in people under age 50

Researchers have completed a comprehensive analysis of cancer statistics for different age groups in the United States and found that from 2010 through 2019, the incidence of 14 cancer types increased among people under age 50.

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Incidence rates of some cancer types have risen in people under age 50

Researchers have completed a comprehensive analysis of cancer statistics for different age groups in the United States and found that from 2010 through 2019, the incidence of 14 cancer types increased among people under age 50.

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Incidence of several early-onset cancers increased between 2010 and 2019

In the United States, breast, colorectal, endometrial, pancreatic, and kidney cancers are becoming increasingly common among people under age 50, according to a new study.

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Incidence of several early-onset cancers increased between 2010 and 2019

In the United States, breast, colorectal, endometrial, pancreatic, and kidney cancers are becoming increasingly common among people under age 50, according to a new study.

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Removing ovaries and fallopian tubes linked to lower risk of early death among breast cancer patients with BRCA cancer genes

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer. Now, researchers have shown that this procedure -- known as bilateral salpingo-oophorectomy (BSO) -- is associated with a substantial reduction in the risk of early death among these women, without any serious side-effects.

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Removing ovaries and fallopian tubes linked to lower risk of early death among breast cancer patients with BRCA cancer genes

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer. Now, researchers have shown that this procedure -- known as bilateral salpingo-oophorectomy (BSO) -- is associated with a substantial reduction in the risk of early death among these women, without any serious side-effects.

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AI-human task-sharing could cut mammography screening costs by up to 30%

The most effective way to harness the power of artificial intelligence when screening for breast cancer may be through collaboration with human radiologists -- not by wholesale replacing them, says new research.

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AI could help improve early detection of interval breast cancers

A new study suggests that artificial intelligence (AI) could help detect interval breast cancers before they become more advanced and harder to treat.

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Drug combination reduces breast cancer risk and improves metabolic health in rats

Researchers investigated the combined effects of bazedoxifene and conjugated estrogens in rat models as an alternative to tamoxifen.

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Low iron could cause brain fog during menopause transition

New research sheds light on an understudied area of science: iron levels in the blood and their relationship to cognitive performance in women transitioning into menopause. The findings are good news for women experiencing brain fog and other symptoms.

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Breast cancer mortality in women ages 20-49 significantly dropped between 2010 and 2020

Breast cancer deaths among women ages 20-49 declined significantly between 2010 and 2020, according to a new study.

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Breast cancer mortality in women ages 20-49 significantly dropped between 2010 and 2020

Breast cancer deaths among women ages 20-49 declined significantly between 2010 and 2020, according to a new study.

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New machine algorithm could identify cardiovascular risk at the click of a button

An automated machine learning program has been able to identify potential cardiovascular incidents or fall and fracture risks based on bone density scans taken during routine clinical testing.

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Can hormone therapy improve heart health in menopausal women?

Oral hormone therapy may benefit heart health in menopausal women. A new analysis of data from the Women's Health Initiative found that estrogen-based oral hormone therapy had a long-term beneficial effect on biomarkers of cardiovascular health, including cholesterol.

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Telehealth might be a good option for women with incontinence

Women who experience urinary incontinence after giving birth may get just as much relief from telehealth as they do from physical therapy, a new study has found.

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Menopause at an early age can exacerbate cognitive decline

Why does dementia affect more women than men? To help solve this mystery, researchers uncovered a new risk factor: age of menopause onset.

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Researchers report association between urinary incontinence, cardiovascular disease

Researchers report an association between urinary incontinence and cardiovascular disease risk in women. The researcher recommend women should be checked regularly for urinary incontinence.

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Are high support bras bad for the back?

Researchers uncover how over-reducing breast motion in bras could increase back pain during exercise.

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Running on empty: Poor nutrition increases injury risk for female athletes

Proper nutrition is crucial for enhancing athletic performance, supporting recovery and overall health. Now, a new study reveals that proper nutrition is also key to reducing risk of injury, especially for females.

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Discovery of mitochondrial protein opens path to therapeutic advances for heart and Alzheimer's disease

Calcium transport into and out of mitochondria -- the powerhouses of cells -- is central to cellular energy production and cell death. To maintain the balance of calcium within these powerhouses, cells rely on a protein known as the mitochondrial sodium-calcium exchanger, or NCLX. Now, in new research, scientists have discovered a novel regulator of NCLX activity, a protein called TMEM65, which helps move calcium out of mitochondria, protecting against harmful calcium overload.

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Estrogen and progesterone stimulate the body to make opioids

Female hormones can suppress pain by making immune cells near the spinal cord produce opioids, a new study has found. This stops pain signals before they get to the brain. The discovery could help with developing new treatments for chronic pain. It may also explain why some painkillers work better for women than men and why postmenopausal women experience more pain.

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Rates of breast and colorectal cancer screening nearly four-fold higher than lung cancer screening among those eligible

Lung cancer screening has the potential to catch lung cancer early and save lives -- but only if people get screened. Although lung cancer screening is recommended in the U.S. for certain individuals with a history of smoking, only 18% of eligible individuals in the U.S. get screened. One suggested explanation has been that those eligible are resistant to receiving preventive healthcare, but a new study indicates otherwise.

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Omega-6 fatty acid promotes the growth of an aggressive type of breast cancer, study finds

Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat 'triple negative' breast cancer subtype, according to a preclinical study. The discovery could lead to new dietary and pharmaceutical strategies against breast and other cancers.

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Omega-6 fatty acid promotes the growth of an aggressive type of breast cancer, study finds

Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat 'triple negative' breast cancer subtype, according to a preclinical study. The discovery could lead to new dietary and pharmaceutical strategies against breast and other cancers.

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How a Y chromosome gene may shape the course of heart valve disease

Researchers have shed new light on how a type of heart valve disease -- aortic valve stenosis -- progresses differently in males and females.

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AI-powered mammograms: A new window into heart health

Mammograms, with the help of artificial intelligence (AI) models, may reveal much more than cancer, according to a new study. The findings highlight how these important cancer screening tools can also be used to assess the amount of calcium buildup in the arteries within breast tissue -- an indicator of cardiovascular health.

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Vaccine may improve breast cancer treatment outcomes

Researchers have discovered a promising new vaccine strategy for treating a specific type of breast cancer. The innovative approach targets human epidermal growth factor receptor 2-positive, estrogen receptor-negative (HER2-positive, ER-negative) breast cancer and has shown encouraging results in a recent pilot study. The study combined the HER2-targeting dendritic cell vaccines with standard chemotherapy, demonstrating both safety and positive response rates.

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Vaccine may improve breast cancer treatment outcomes

Researchers have discovered a promising new vaccine strategy for treating a specific type of breast cancer. The innovative approach targets human epidermal growth factor receptor 2-positive, estrogen receptor-negative (HER2-positive, ER-negative) breast cancer and has shown encouraging results in a recent pilot study. The study combined the HER2-targeting dendritic cell vaccines with standard chemotherapy, demonstrating both safety and positive response rates.

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Slow, silent 'scream' of epithelial cells detected for first time

It has long been thought that only nerve and heart cells use electric impulses to communicate, while epithelial cells -- which compose the linings of our skin, organs and body cavities -- are mute, serving mostly as protective barriers that can absorb and secrete various substances. But researchers have now upended the status quo by showing that epithelial cells do indeed 'talk' to each other, albeit with slow electrical signals.

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Oxytocin system of breastfeeding affected in mothers with postnatal depression

The oxytocin system -- which helps release breast milk and strengthens the bond between mother and baby -- may be affected during breastfeeding in mothers experiencing postnatal depression.

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New antibody reduces tumor growth in treatment-resistant breast and ovarian cancers

A new type of antibody which stimulates the immune system to target cancer cells slows tumour growth, according to new research.

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Nwd1 gene deletion triggers MASH-like pathology in mice

Metabolic dysfunction-associated steatohepatitis (MASH) is a polygenic disorder influenced by multiple genes, but their specific roles in the progression of disease remain unknown. To address this gap, researchers conducted a series of experiments that identified the NACHT and WD repeat domain-containing protein 1 (Nwd1) gene and its role in liver pathogenesis. This breakthrough represents an important step toward establishing new therapeutic targets for MASH.

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Exercise and healthy eating behavior together provide the best protection against cardiovascular diseases

Researchers have found that women who exhibit disturbed eating behaviors and engage in low physical activity tend to have more central body fat and a higher risk of metabolic low-grade inflammation. This condition increases the risk of cardiovascular diseases, which become more prevalent after menopause. However, the combined effect of exercise and healthy eating behavior offers the most effective protection against inflammation and may also reduce it after menopause.

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Diabetes drug could help cancer patients make better recovery

Research shows that a common type of diabetes medication could help cancer patients make a better long-term recovery. Many cancer patients go on to develop heart failure -- because of the cancer itself and also due to chemotherapy. But a study shows that a type of diabetes drug, called an SGLT2 inhibitor, may help protect the heart during and after cancer treatment. The medication has been shown to be beneficial in reducing heart failure or heart failure hospitalisation in cancer patients and survivors.

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Links between metabolism and aggressive breast cancer

More than 120 million Americans suffer from diabetes or pre-diabetes. Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and TNBC patients with obesity-driven diabetes often have worse outcomes. A new study helps explain why this happens and suggests a potential way to improve treatment for these patients.

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Breakthrough cardiac regeneration research offers hope for the treatment of ischemic heart failure

The discovery of a novel approach to promote cardiomyocyte proliferation offers new hope for the treatment of ischemic heart failure.

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Breakthrough cardiac regeneration research offers hope for the treatment of ischemic heart failure

The discovery of a novel approach to promote cardiomyocyte proliferation offers new hope for the treatment of ischemic heart failure.

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Scientists upends scientific understanding of how anticancer drugs kill cancer

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research illustrates how small breaks in one strand of DNA can expand into a large single-stranded DNA gap that kills drug-resistant breast BRCA mutant cancer cells. The novel vulnerability in mutant BRCA1 and BRCA2 may be a potential target for new therapeutics.

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Future drugs may snap supply chain fueling breast cancer

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy. These enzymes, called creatine kinases (CK), allow cells to transport energy produced at the mitochondria to where it is needed throughout the cell. Studies of breast cancer cells have highlighted the importance of a type of CK called ubiquitous mitochondrial creatine kinase (uMtCK).

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Study establishes 'ball and chain' mechanism inactivates key mammalian ion channel

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a 'ball-and-chain' channel-plugging mechanism. The findings boost the understanding of ion channel biology and could lead to new drugs that target these channels to treat disorders such as epilepsy and hypertension.

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Researchers unravel menopause timing, shedding light on ovarian aging and fertility

The research team has developed a theoretical framework that quantitatively predicts menopause timing. By analyzing how ovarian follicles transition through different stages, the researchers' model explains why menopause occurs and sheds light on individual variability and cross-population differences. These insights could improve fertility planning, inform health care decisions related to hormonal therapies and enhance our understanding of age-related health risks associated with ovarian aging.

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Researchers develop novel computational approach for identifying synergistic drug combinations

Researchers have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases. The study highlights iDOMO's ability to identify synergistic drug combinations using gene expression data, outperforming existing methods.

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Data from all 50 states shows early onset breast cancer is on the rise in younger women: Does place of exposure matter?

Breast cancer incidence trends in U.S. women under 40 vary by geography and supports incorporating location information with established risk factors into risk prediction, improving the ability to identify groups of younger women at higher risk for early-onset breast cancer.

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Data from all 50 states shows early onset breast cancer is on the rise in younger women: Does place of exposure matter?

Breast cancer incidence trends in U.S. women under 40 vary by geography and supports incorporating location information with established risk factors into risk prediction, improving the ability to identify groups of younger women at higher risk for early-onset breast cancer.

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Nerves electrify stomach cancer, sparking growth and spread

Researchers have found that a cancer outside the brain makes electrical connections with the nervous system to fuel cancer growth and aid its spread.

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Speculum exams unnecessary for HPV screening

Researchers have demonstrated that self-sampling is just as effective as speculum-based testing for HPV detection.

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Sweet taste receptors in the heart: A new pathway for cardiac regulation

In a surprising discovery, scientists have found that the heart possesses 'sweet taste' receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can modulate the heartbeat. This research opens new avenues for understanding heart function and potentially for developing novel treatments for heart failure.

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Landmark atlas reveals how aging breast tissue shapes breast cancer risk

Aging is a privilege, but it also brings risks -- including an increased likelihood of developing age-related diseases including cancer. Researchers have now created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.

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Landmark atlas reveals how aging breast tissue shapes breast cancer risk

Aging is a privilege, but it also brings risks -- including an increased likelihood of developing age-related diseases including cancer. Researchers have now created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.

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Disordered eating and certain foods linked to higher risk for urinary incontinence in middle-aged women

Eating behavior is associated with symptoms of pelvic floor disorders in middle-aged women. For example, higher consumption of highly processed ready-made foods and fast food increased the risk for experiencing symptoms of stress and urgency urinary incontinence. Higher consumption of fruits and an overall higher quality diet decreased the risk for stress urinary incontinence.

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Innovative dual-target drug may lead to new investigational approach for breast cancer patients

Researchers discover new insights into how dual-target drug may supercharge cancer-fighting immune cells.

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Ovarian cancer discovery could turn failed treatment into lifesaver

Gut bacteria are to blame for the failure of immune checkpoint therapy for ovarian cancer, new research reveals.

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Disruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long noncoding RNA (lncRNA) 'XIST' could be an effective therapeutic strategy for treating aggressive breast cancer.

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Breast cancers broadly defined by their genome architecture

Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues.

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Breast cancers broadly defined by their genome architecture

Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues.

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Drug may counteract muscle loss and osteoporosis after rapid weight loss

Rapid weight loss affects muscle mass and can increase the risk of osteoporosis. But now there is good news for people taking weight loss medication who may be at risk. A new study indicates that the drug bimagrumab can counteract the side effects.

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From muscle to memory: New research uses clues from the body to understand signaling in the brain

New research shows that a network of subcellular structures similar to those responsible for propagating molecular signals that make muscles contract are also responsible for transmitting signals in the brain that may facilitate learning and memory.

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Fear of breast cancer recurrence: Impact and coping with being in a dark place

A new study of breast cancer survivors has found this psychosocial challenge impacts almost every important domain of their lives -- the emotional, behavioral, cognitive, relational and professional. A larger number of domains was affected, and they were affected more frequently in those with greater fear of recurrence. The majority of study participants indicated that they sought senses of purpose, belonging, control and connection with others.

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Later-onset menopause linked to healthier blood vessels, lower heart disease risk

New research shows that women who hit menopause later in life have healthier blood vessels and mitochondria and a different composition of metabolites in their blood than those who stop menstruating earlier. The study helps explain why late-onset menopause is linked to lower risk of heart attacks and strokes.

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Communication between body muscle and the brain influences fertility

A newly discovered line of communication between body muscle and the pituitary gland may play an unexpected role in female fertility, according to a new study. Researchers found that a protein produced in the muscles helps manage the release of a hormone made in the pea-sized gland attached to the base of the brain.

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How hungry fat cells could someday starve cancer to death

Liposuction and plastic surgery aren't often mentioned in the same breath as cancer. But they are the inspiration for a new approach to treating cancer that uses engineered fat cells to deprive tumors of nutrition. Researchers at UC San Francisco used the gene editing technology CRISPR to turn ordinary white fat cells into 'beige' fat cells, which voraciously consume calories to make heat.

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Inhibitor drugs to treat aggressive breast cancer identified

A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.

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Removing fallopian tubes during other abdominal surgeries may lower ovarian cancer risk

A mathematical modeling study suggests that ovarian cancer incidence could be reduced and healthcare savings boosted if women who have already completed their families were offered fallopian tube removal during any other suitable abdominal surgeries.

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Study shows potential of resveratrol to aid fertility

A new study has highlighted the potential of resveratrol, a natural compound found in grapes, blueberries, and raspberries, to enhance female fertility. The systematic review found that resveratrol can improve the quantity and quality of egg cells, offering hope for new, less invasive fertility treatments.

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An injectable hydrogel for local bone densification

Researchers have combined injections of a novel hydrogel with systemic osteoporosis drugs in rats, achieving rapid local increases in bone density. The results offer hope for future fracture prevention therapies in osteoporosis patients.

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Routine brain MRI screening in asymptomatic late stage breast cancer patients

A new study shows that asymptomatic brain metastasis is more common in stage 4 breast cancer patients than previously believed. The study suggests that doctors may need to rethink current screening guidelines for detecting brain metastasis in patients without symptoms.

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Inherited gene elevates prostate cancer risk in affected families

The inherited mutated gene WNT9B, which functions normally in embryonic prostate development, increases risk of adult prostate cancer, according to a new study.

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Dissolving clusters of cancer cells to prevent metastases

Successful test in breast cancer patients: the active agent digoxin, a cardiac medication, dissolves clusters of circulating breast cancer cells in the blood, thus reducing the risk of metastases formation.

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Dissolving clusters of cancer cells to prevent metastases

Successful test in breast cancer patients: the active agent digoxin, a cardiac medication, dissolves clusters of circulating breast cancer cells in the blood, thus reducing the risk of metastases formation.

from Women's Health News -- ScienceDaily https://ift.tt/oz36fCY

New combination immunotherapy for melanoma and breast cancer

A research team has investigated a new combination therapy against cancer. This therapy employs systemic administration of the tissue hormone interferon-I combined with local application of Imiquimod. This combination showed promising results in topically accessible tumors like melanoma and breast cancer models: The therapy led to the death of tumor cells at the treated sites and simultaneously activated the adaptive immune system to fight even distant metastases. The results could improve the treatment of superficial tumors such as melanoma and breast cancer.

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New combination immunotherapy for melanoma and breast cancer

A research team has investigated a new combination therapy against cancer. This therapy employs systemic administration of the tissue hormone interferon-I combined with local application of Imiquimod. This combination showed promising results in topically accessible tumors like melanoma and breast cancer models: The therapy led to the death of tumor cells at the treated sites and simultaneously activated the adaptive immune system to fight even distant metastases. The results could improve the treatment of superficial tumors such as melanoma and breast cancer.

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Drug candidate eliminates breast cancer tumors in mice in a single dose

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots. Now, researchers have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects.

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Drug candidate eliminates breast cancer tumors in mice in a single dose

Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots. Now, researchers have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects.

from Women's Health News -- ScienceDaily https://ift.tt/mt98gEp

Telephone therapy reduces fatigue interference with activities, mood and cognition for metastatic breast cancer survivors

A clinical trial demonstrates the effectiveness of telephone-delivered acceptance and commitment therapy (ACT) in reducing fatigue's interference with functioning and improving the quality of life for survivors of metastatic breast cancer. The ACT intervention helped study participants to fall asleep with greater ease. Fatigue remains a significant challenge for these survivors, affecting up to 63 percent of patients and severely impacting daily functioning.

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Rotavirus protein NSP4 manipulates gastrointestinal disease severity

Researchers have improved our understanding of how rotavirus, the most common cause of acute gastroenteritis in children, makes people sick. The study is among the first to show that the rotavirus protein NSP4 is both necessary and sufficient for multiple aspects of rotavirus infection by disrupting calcium signaling not only within infected cells but also in nearby uninfected cells. These disruptions in calcium signaling affect rotavirus disease severity, providing new insights into how NSP4's function influences rotavirus virulence. The findings suggest that manipulating NSP4 could lead to new strategies to prevent or treat rotavirus infections.

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Drug in clinical trials for breast cancer could also treat some blood cancers

Two new studies have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

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Cancer mortality continues to drop despite rising incidence in women

The American Cancer Society (ACS) today released Cancer Statistics, 2025, the organization's annual report on cancer facts and trends. The new findings show the cancer mortality rate declined by 34% from 1991 to 2022 in the United States, averting approximately 4.5 million deaths. However, this steady progress is jeopardized by increasing incidence for many cancer types, especially among women and younger adults, shifting the burden of disease. For example, incidence rates in women 50-64 years of age have surpassed those in men, and rates in women under 50 are now 82% higher than their male counterparts, up from 51% in 2002.

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Researchers resolve uncertainty in BRCA2 testing, improving cancer risk assessment and patient care

Findings from a multi-institutional, international study have significantly advanced the understanding of genetic alterations in the BRCA2 gene, a key player in hereditary cancer risk.

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Researchers boost chemotherapy uptake in breast cancer treatment with localized magnetic fields

Researchers have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects. By applying brief, localized pulses of magnetic fields, the team demonstrated a significant increase in the uptake of doxorubicin (DOX), a widely used chemotherapy drug, into breast cancer cells, with minimal impact on healthy tissues.

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Researchers boost chemotherapy uptake in breast cancer treatment with localized magnetic fields

Researchers have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects. By applying brief, localized pulses of magnetic fields, the team demonstrated a significant increase in the uptake of doxorubicin (DOX), a widely used chemotherapy drug, into breast cancer cells, with minimal impact on healthy tissues.

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Approaches against metastatic breast cancer: mini-tumors from circulating cancer cells

Tumor cells circulating in the blood are the 'germ cells' of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult. A team has now succeeded for the first time in cultivating stable tumor organoids directly from blood samples of breast cancer patients. Using these mini-tumors, the researchers were able to decipher a molecular signaling pathway that ensures the cancer cells' survival and resistance to therapy. With this knowledge, the team was able to develop an approach to specifically eliminate these tumor cells in lab experiments.

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Patients with heart disease may be at increased risk for advanced breast cancer

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

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Patients with heart disease may be at increased risk for advanced breast cancer

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

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Achieving bone regeneration and adhesion with harmless visible light

A team develops an innovative injectable hydrogel for bone regeneration, addressing the limitations of traditional bone grafts and adhesion methods.

from Women's Health News -- ScienceDaily https://ift.tt/u0biAyq