Manipulation of gut microbiota with flaxseed could reduce breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. 

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Manipulation of gut microbiota with flaxseed could reduce breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. 

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Early life gene epimutation may cause breast cancer

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene, called BRCA1. 

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Early life gene epimutation may cause breast cancer

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene, called BRCA1. 

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Blood hormone levels key to identifying which post-menopausal women will benefit most from taking anastrozole to prevent breast cancer

has found that hormone levels, measured through blood tests, are an important indicator of whether women will benefit from recently licensed medication for the prevention of breast cancer.

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New study uses genetic data to support use of thiazide diuretics for kidney stone prevention

Kidney stones affect nearly 10% of the global population. For more than three decades, thiazide diuretics, a common medication used for high blood pressure, have been the standard of care for kidney stone prevention because they reduce the excretion of urinary calcium.  

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How pre- and postnatal B-12 vitamins improve breast milk vitamin B-12 levels, which supports infant brain development

According to a new study B-12 vitamins increase the presence of the micronutrient in mothers' breast milk, which is especially helpful in countries where it can be difficult to eat what is needed for the body to produce B-12 naturally.

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Novel molecular mechanisms in the early development of diabetes mellitus

Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of Anxa10 expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated Anxa10 expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin secretory capacity.

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Urban environmental exposures drive increased breast cancer incidence

An analysis of breast cancer showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis.

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Urban environmental exposures drive increased breast cancer incidence

An analysis of breast cancer showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis.

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Reducing vitamin B5 slows breast cancer growth in mice

Researchers have discovered that breast cancer cells expressing a cancer-driving gene heavily rely on vitamin B5 to grow and survive.

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Higher risk of breast cancer in women with false positive mammography result

Women who receive a false positive mammography result are more likely to develop breast cancer over the subsequent 20 years, report researchers. The risk is highest for women aged between 60 and 75 and who have low breast density.

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Higher risk of breast cancer in women with false positive mammography result

Women who receive a false positive mammography result are more likely to develop breast cancer over the subsequent 20 years, report researchers. The risk is highest for women aged between 60 and 75 and who have low breast density.

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COVID vaccination in female, male partners does not increase risk of miscarriage, study finds

A new study provides deeper insight into the safety of COVID-19 vaccines for people planning to become pregnant. The study found no increased risk of early or late miscarriage as a result of male or female partners getting a COVID-19 vaccine prior to conceiving.

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Cutting-edge imaging sheds new light on cells that break down bone

Imaging technology shows that bone-resorbing osteoclasts gather in distinct pockets, leading to new insights for osteoporosis and cancer treatment.

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Nanoparticle vaccine could curb cancer metastasis to lungs by targeting a protein

Engineers have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs. Its success lies in targeting a protein known to play a central role in cancer growth and spread, rather than targeting the primary tumor itself.

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Researchers uncover mechanism that links NAD+ to fertility problems

A woman's fertility normally decreases by her late 30s with reproductive function eventually ceasing at menopause. It is known that a small molecule called nicotinamide adenine dinucleotide (NAD+) plays a critical role in this decline, and scientists have revealed how this happens and have identified potential new approaches to enhance reproductive longevity.

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Empathetic cancer clinicians promote psychological well-being in breast cancer patients

Clinicians who show more empathy promote better psychological health among breast cancer patients, according to a new study examining how oncology doctors facilitate psychological well-being.

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New 3D-printed tumor model enables faster, less expensive and less painful cancer treatment

A team combined cutting-edge bioprinting techniques with synthetic structures or microfluidic chips. The method will help lab researchers more accurately understand heterogeneous tumors: Tumors with more than one kind of cancer cell, often dispersed in unpredictable patterns. 

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Wearable patch wirelessly monitors estrogen in sweat

A new sensor may make it easier for women to monitor their estradiol, which plays a role in health and fertility.

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Is a longer reproductive lifespan good for your brain?

People with a higher cumulative estrogen exposure throughout their life may have a lower risk of cerebral small vessel disease, according to a new study.

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Study finds significant chemical exposures in women with cancer

Exposure to endocrine-disrupting chemicals like PFAS and phenols are implicated in hormone-mediated cancers of the breast, ovaries, skin and uterus. To learn more about the environmental exposures experienced by women who developed these cancers, researchers analyzed data from NHANES and found that women who reported having cancer had significantly higher levels of these chemicals in their bodies.

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Groundbreaking research unveils genetic characteristics and improved prognosis of triple negative apocrine carcinoma

A research team has led a groundbreaking study that delves into the exploration of triple-negative apocrine carcinoma.

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New method offers hope of fewer fractures

Thousands of people could be spared from a hip fracture each year if a new method to identify the risk of osteoporotic fractures were to be introduced in healthcare. This is the view of the researchers who are behind a new 3D-simulation method.

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Breast cancer recurrence may be triggered by chemotherapy injury to non-cancer cells

A standard chemotherapy drug injures surrounding non-cancer cells, which can then awakens dormant cancer cells and promotes cancer growth, according to a new study. The finding is important for understanding cancer recurrence and may point to important new targets to prevent it.

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Study reveals reductions in breast cancer screening uptake during COVID-19 pandemic

A review of COVID-19 studies globally has revealed reductions in breast cancer screening participation during 2020, with differences between geographic regions and healthcare settings.

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High levels of particulate air pollution associated with increased breast cancer incidence

Researchers found that living in an area with high levels of particulate air pollution was associated with an increased incidence of breast cancer. The study is one of the largest studies to date looking at the relationship between outdoor air pollution, specifically fine particulate matter, and breast cancer incidence.

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Review of over 70 years of menopause science highlights research gaps and calls for individualized treatment

Although about half of people go through menopause, less than 15% of them receive effective treatment for their symptoms. Treatment options for people experiencing irritating or severe menopause symptoms are often under researched, and some have questionable efficacy, or cause harmful side effects. Menopause experts now summarize what we know about menopause, call for more research into the timeline and treatment of menopause, and encourage individualized, holistic treatment that addresses both menopausal symptoms and other systemic changes happening in the body.

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'Gates of Heaven' calcium channel drives oral cancer pain and growth

An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study. Targeting this protein -- the ORAI1 calcium channel -- could provide a new approach to treating oral cancer, which causes persistent pain that worsens as it progresses.

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AI performs comparably to human readers of mammograms

Using a standardized assessment, researchers in the UK compared the performance of a commercially available artificial intelligence algorithm with human readers of screening mammograms.

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AI performs comparably to human readers of mammograms

Using a standardized assessment, researchers in the UK compared the performance of a commercially available artificial intelligence algorithm with human readers of screening mammograms.

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Software analyzes calcium 'sparks' that can contribute to arrhythmia

Researchers developed a new software tool, SparkMaster 2, that allows scientists to analyze normal and abnormal calcium activity in cells.

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New genes and natural toxins offer hope for cancer patients unresponsive to chemotherapy

Scientists have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive to chemotherapy subsequently respond to it.

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Unraveling the long history of breast cancer formation

The mechanism by which breast cancer is formed in the cells of mammalian epithelium has been discovered. Although roughly 20 mutations accumulate annually in each epithelial cell until menopause, the mutation rate significantly decreases after menopause. Accumulation also decreased after childbirth, suggesting the effect of estrogen in mammary epithelium.

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Unraveling the long history of breast cancer formation

The mechanism by which breast cancer is formed in the cells of mammalian epithelium has been discovered. Although roughly 20 mutations accumulate annually in each epithelial cell until menopause, the mutation rate significantly decreases after menopause. Accumulation also decreased after childbirth, suggesting the effect of estrogen in mammary epithelium.

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Estrogen-negative cancers respond to anti-estrogenic therapies

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

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Estrogen-negative cancers respond to anti-estrogenic therapies

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

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Breast size affects women's attitudes to exercise

Women with larger breasts tend to exercise less frequently and avoid high-intensity exercise and a new study has found much improved participation in recreational group exercises after breast reduction surgery. The new study further strengthens calls for more accessible, publicly funded breast reduction and other interventions in some cases.

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Radiation may not be necessary for patients with low-risk breast cancer

Researchers have found some women with early-stage, low-risk breast cancer may not need radiotherapy after breast conserving surgery.

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Radiation may not be necessary for patients with low-risk breast cancer

Researchers have found some women with early-stage, low-risk breast cancer may not need radiotherapy after breast conserving surgery.

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Outdoor air pollution may increase non-lung cancer risk in older adults

Chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) may increase non-lung cancer risk in older adults, according to a new study. In a cohort study of millions of Medicare beneficiaries, the researchers found that exposures to PM2.5 and NO2 over a 10-year period increased the risk of developing colorectal and prostate cancers. The researchers also found that even low levels of air pollution exposure may make people particularly susceptible to developing these cancers, in addition to breast and endometrial cancers.

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Safety of AI-supported mammography screening

Mammography screening supported by artificial intelligence (AI) is a safe alternative to today's conventional double reading by radiologists and can reduce heavy workloads for doctors. This has now been shown in an interim analysis of a prospective, randomised controlled trial, which addressed the clinical safety of using AI in mammography screening.

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Team identifies key driver of cancer cell death pathway that activates immune cells

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

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Team identifies key driver of cancer cell death pathway that activates immune cells

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

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A wearable ultrasound scanner could detect breast cancer earlier

In hopes of improving the survival rate for breast cancer patients, researchers designed a wearable ultrasound device that could allow women to detect tumors when they are still in early stages.

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A wearable ultrasound scanner could detect breast cancer earlier

In hopes of improving the survival rate for breast cancer patients, researchers designed a wearable ultrasound device that could allow women to detect tumors when they are still in early stages.

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Scientists make promising discovery in fight against breast cancer

Scientists have discovered a possible way to block proteins produced in the body when a patient has cancer and which causes its spread to other parts of the body.

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Women treated for breast cancer may age faster than cancer-free women

Women diagnosed and treated for breast cancer have increased biological aging compared to women who remain free of breast cancer, according to a new study. Among women diagnosed with breast cancer, the association with faster biological aging was most pronounced for those who received radiation therapy, while surgery showed no association with biological aging. This finding suggests that developing cancer is not what increases the aging effect.

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Women treated for breast cancer may age faster than cancer-free women

Women diagnosed and treated for breast cancer have increased biological aging compared to women who remain free of breast cancer, according to a new study. Among women diagnosed with breast cancer, the association with faster biological aging was most pronounced for those who received radiation therapy, while surgery showed no association with biological aging. This finding suggests that developing cancer is not what increases the aging effect.

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A quick and inexpensive test for osteoporosis risk

As life expectancy increases worldwide, age-associated diseases such as osteoporosis are having an increasing impact. Although early detection could help physicians intervene as soon as possible -- when treatment might offer the greatest benefit -- this type of detection is not yet possible with current osteoporosis diagnostic tests. Now, researchers have developed a biosensor that could someday help identify those most at risk for osteoporosis using less than a drop of blood.

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New study using human fibroid cells supports use of green tea compound as treatment for uterine fibroids

In a pre-clinical, proof-of-concept study, researchers found that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids. Results of the study add to growing evidence that EGCG may reduce fibroid cell growth. The study was specifically designed to identify the biochemical mechanisms responsible for EGCG action in fibroid cells.

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Largest-ever atlas of normal breast cells brings unprecedented insights into mammary biology

A new study has created the world's largest and most comprehensive map of normal breast tissue, providing an unprecedented understanding of mammary biology that may help identify therapeutic targets for diseases such as breast cancer. The Human Breast Cell Atlas used single-cell and spatial genomic methods to profile more than 714,000 cells from 126 women. The breast atlas highlights 12 major cell types and 58 biological cell states, and identifies differences based on ethnicity, age and the menopause status of healthy women.

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Helping 'good' gut bacteria and clearing out the 'bad' -- all in one treatment

Probiotics can help maintain a healthy gut microbiome or restore populations of 'good bacteria' after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers have developed a microgel delivery system for probiotics that keeps 'good' bacteria safe while actively clearing out 'bad' ones. In mice, the system treated intestinal inflammation without side effects.

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A 'pinch' of mineral salts helps the noncaloric sweeteners go down

Perfect noncaloric replacements for sugar and high fructose corn syrup just don't exist yet. For example, some alternatives have a lingering sweet aftertaste and lack a sugar-like mouthfeel, leaving some consumers unsatisfied. Now, researchers propose adding blends of nutritionally important mineral salts to make noncaloric sweeteners seem more like the real thing. Taste-testers indicated that these blends gave zero- and low-calorie drinks a better flavor.

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New study links contraceptive pills and depression

Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study. Contraceptive pills increased women's risk by 73 per cent during the first two years of use.

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How breast cancer arises

Researchers trace the origin of certain breast cancers to genomic reshuffling -- rearrangement of chromosomes -- that activates cancer genes and ignites disease. The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development. The study shows the sex hormone estrogen -- thus far thought to be only a fuel for breast cancer growth -- can directly cause tumor-driving genomic rearrangements.

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How breast cancer arises

Researchers trace the origin of certain breast cancers to genomic reshuffling -- rearrangement of chromosomes -- that activates cancer genes and ignites disease. The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development. The study shows the sex hormone estrogen -- thus far thought to be only a fuel for breast cancer growth -- can directly cause tumor-driving genomic rearrangements.

from Women's Health News -- ScienceDaily https://ift.tt/1GM2yt7

How breast cancer arises

Researchers trace the origin of certain breast cancers to genomic reshuffling -- rearrangement of chromosomes -- that activates cancer genes and ignites disease. The finding offers a long-missing explanation for many cases of the disease that remain unexplained by the classical model of breast cancer development. The study shows the sex hormone estrogen -- thus far thought to be only a fuel for breast cancer growth -- can directly cause tumor-driving genomic rearrangements.

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Gamma delta T cells can fight aggressive breast cancer

Researchers discover a mechanism by which cancer cells escape the immune system.

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Gamma delta T cells can fight aggressive breast cancer

Researchers discover a mechanism by which cancer cells escape the immune system.

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Gamma delta T cells can fight aggressive breast cancer

Researchers discover a mechanism by which cancer cells escape the immune system.

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Is bone health linked to brain health?

People who have low bone density may have an increased risk of developing dementia compared to people who have higher bone density. The study does not prove that low bone density causes dementia. It only shows an association.

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A new combination therapy regimen shows promising results for prostate cancer

The combination of two oral medications has shown positive results in people with prostate cancer, whose disease has spread to other parts of the body. Compared with XTANDI plus placebo, the investigatory combination of TALZENNA and XTANDI demonstrated a statistically significant and clinically meaningful improvement in radiographic progression-free survival.

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Disproportionate percentage of females with unexplained infertility have gene variants known to cause heart problems, cancer

About 17% of women with unexplained infertility also have gene variants known to cause disease, from common conditions like heart disease to rare problems like ALS, researchers report.

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Disproportionate percentage of females with unexplained infertility have gene variants known to cause heart problems, cancer

About 17% of women with unexplained infertility also have gene variants known to cause disease, from common conditions like heart disease to rare problems like ALS, researchers report.

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Scientists discover a new way to help prevent breast cancer 'time bomb'

Scientists have discovered why breast cancer cells that have spread to the lungs may 'wake up' following years of sleep -- forming incurable secondary tumors. Their research reveals the mechanism that triggers this breast cancer 'time bomb' -- and suggests a strategy to defuse it.

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Scientists discover a new way to help prevent breast cancer 'time bomb'

Scientists have discovered why breast cancer cells that have spread to the lungs may 'wake up' following years of sleep -- forming incurable secondary tumors. Their research reveals the mechanism that triggers this breast cancer 'time bomb' -- and suggests a strategy to defuse it.

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Scientists discover a new way to help prevent breast cancer 'time bomb'

Scientists have discovered why breast cancer cells that have spread to the lungs may 'wake up' following years of sleep -- forming incurable secondary tumors. Their research reveals the mechanism that triggers this breast cancer 'time bomb' -- and suggests a strategy to defuse it.

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Migraines during menstruation: Low estrogen levels paired with higher CGRP levels may jump start migraine

As estrogen levels fluctuate, a new study has found for female participants with migraine, their levels of the protein calcitonin gene-related peptide (CGRP) that plays a key role in starting the migraine process also fluctuate.

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Migraines during menstruation: Low estrogen levels paired with higher CGRP levels may jump start migraine

As estrogen levels fluctuate, a new study has found for female participants with migraine, their levels of the protein calcitonin gene-related peptide (CGRP) that plays a key role in starting the migraine process also fluctuate.

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Predicting two common heart conditions

Two novel research studies move the needle on predicting two important heart conditions -- sudden cardiac arrest, which is often fatal, and increased coronary artery calcium, a marker of coronary artery disease that can lead to a heart attack.

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Predicting two common heart conditions

Two novel research studies move the needle on predicting two important heart conditions -- sudden cardiac arrest, which is often fatal, and increased coronary artery calcium, a marker of coronary artery disease that can lead to a heart attack.

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Body Dissatisfaction Can Lead to Eating Disorders at Any Age

Eating disorders are stereotypically associated with adolescents and young adults. Growing evidence, however, suggests that these conditions can occur at any time during a woman's lifespan, including at midlife. A new study finds that body dissatisfaction is a primary cause of eating disorders, especially during perimenopause.

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Body Dissatisfaction Can Lead to Eating Disorders at Any Age

Eating disorders are stereotypically associated with adolescents and young adults. Growing evidence, however, suggests that these conditions can occur at any time during a woman's lifespan, including at midlife. A new study finds that body dissatisfaction is a primary cause of eating disorders, especially during perimenopause.

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HRT could ward off Alzheimer's among at-risk women

Hormone Replacement Therapy (HRT) could help prevent Alzheimer's Dementia among women at risk of developing the disease -- according to new research.

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