Cystic fibrosis drug could help treat pneumonia

Pathogens such as SARS-CoV-2 and pneumococcus can cause severe pneumonia. If the airways then fill with fluid, the patient risks developing acute respiratory distress syndrome. Researchers have now discovered the molecular mechanisms that trigger fluid accumulation in the lungs. This also led them to discover a potential new therapy: A cystic fibrosis drug proved effective in their laboratory experiments, raising hope that this could be used to treat pneumonia regardless of the pathogen that caused it.

from Women's Health News -- ScienceDaily https://ift.tt/OoEAG0V

High-energy X-rays leave a trace of destruction in bone collagen

A team of medical researchers has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II. With a combination of microscopy techniques, the scientists could document the destruction of collagen fibers induced by electrons emitted from the mineral crystals. X-ray methods might impact bone samples when measured for a long time they conclude.

from Women's Health News -- ScienceDaily https://ift.tt/HLO8nIX

High-energy X-rays leave a trace of destruction in bone collagen

A team of medical researchers has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II. With a combination of microscopy techniques, the scientists could document the destruction of collagen fibers induced by electrons emitted from the mineral crystals. X-ray methods might impact bone samples when measured for a long time they conclude.

from Women's Health News -- ScienceDaily https://ift.tt/HLO8nIX

High doses of statins increase osteoporosis risk, shows study in animals

An animal experiment demonstrates what big data analysis previously indicated: high doses of statins likely increase osteoporosis risk.

from Women's Health News -- ScienceDaily https://ift.tt/a7FI1lA

Subcutaneous fat emerges as a protector of females' brains

Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report.

from Women's Health News -- ScienceDaily https://ift.tt/D8gtimV

Subcutaneous fat emerges as a protector of females' brains

Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report.

from Women's Health News -- ScienceDaily https://ift.tt/D8gtimV

Who is more prone to recurrent UTIs? Bladder bacteria may be key

Researchers have identified specific bacteria in the bladder that may indicate which postmenopausal women are more susceptible to recurrent urinary tract infections (UTIs), and they found that estrogen may play a role in reducing that susceptibility.

from Women's Health News -- ScienceDaily https://ift.tt/qsbmy8J

Who is more prone to recurrent UTIs? Bladder bacteria may be key

Researchers have identified specific bacteria in the bladder that may indicate which postmenopausal women are more susceptible to recurrent urinary tract infections (UTIs), and they found that estrogen may play a role in reducing that susceptibility.

from Women's Health News -- ScienceDaily https://ift.tt/qsbmy8J

Estrogen may offer protection against delirium

Delirium is common among women with urinary tract infections (UTIs) -- especially those who have experienced menopause. Investigators, working with laboratory mice, have been able to prevent symptoms of the condition with estrogen, which is commonly used for hormone replacement therapy.

from Women's Health News -- ScienceDaily https://ift.tt/8evZNbI

Estrogen may offer protection against delirium

Delirium is common among women with urinary tract infections (UTIs) -- especially those who have experienced menopause. Investigators, working with laboratory mice, have been able to prevent symptoms of the condition with estrogen, which is commonly used for hormone replacement therapy.

from Women's Health News -- ScienceDaily https://ift.tt/8evZNbI

Women with elevated breast cancer risk could see mortality benefit from estrogen-blocking drugs

While it has long been recognized that drugs that block the cancer-promoting activity of estrogen reduce risk of developing new breast cancers, a new computer modeling study has shown that these treatments could also reduce the risk of dying from the disease in women who are at high risk.

from Women's Health News -- ScienceDaily https://ift.tt/avdIZFR

Study in mice suggests that expression of estrogen-related gene can impact post-menopausal breast cancer risk and prevention strategies

In a study using a mouse model of aging that mimics breast cancer development in estrogen receptor-positive post-menopausal women, investigators have determined that over-expression, or switching on of the Esr1 gene, could lead to elevated risk of developing estrogen receptor-positive breast cancer in older women.

from Breast Cancer News -- ScienceDaily https://ift.tt/Lz30Hml

Study in mice suggests that expression of estrogen-related gene can impact post-menopausal breast cancer risk and prevention strategies

In a study using a mouse model of aging that mimics breast cancer development in estrogen receptor-positive post-menopausal women, investigators have determined that over-expression, or switching on of the Esr1 gene, could lead to elevated risk of developing estrogen receptor-positive breast cancer in older women.

from Women's Health News -- ScienceDaily https://ift.tt/Lz30Hml

How women can reduce the risk of hip fracture

Increasing intake of protein and drinking regular cups of tea or coffee is a way women could reduce their risk of suffering a hip fracture, according to new research. Food scientists have found that for women, a 25g a day increase in protein was associated with, on average, a 14% reduction in their risk of hip fracture. In a surprise twist, they also discovered that every additional cup of tea or coffee they drank was linked with a 4% reduction in risk.

from Women's Health News -- ScienceDaily https://ift.tt/tNMuZvf

How women can reduce the risk of hip fracture

Increasing intake of protein and drinking regular cups of tea or coffee is a way women could reduce their risk of suffering a hip fracture, according to new research. Food scientists have found that for women, a 25g a day increase in protein was associated with, on average, a 14% reduction in their risk of hip fracture. In a surprise twist, they also discovered that every additional cup of tea or coffee they drank was linked with a 4% reduction in risk.

from Women's Health News -- ScienceDaily https://ift.tt/tNMuZvf

Birth choices after previous cesarean and risk of pelvic floor surgery

Vaginal birth after a previous cesarean section is associated with an increased risk of pelvic floor surgery compared with planning another cesarean, according to a new study. The findings provide useful information to help women who have had a previous cesarean section when planning how to give birth in their next pregnancy.

from Women's Health News -- ScienceDaily https://ift.tt/mGaISO8

Birth choices after previous cesarean and risk of pelvic floor surgery

Vaginal birth after a previous cesarean section is associated with an increased risk of pelvic floor surgery compared with planning another cesarean, according to a new study. The findings provide useful information to help women who have had a previous cesarean section when planning how to give birth in their next pregnancy.

from Women's Health News -- ScienceDaily https://ift.tt/mGaISO8

Exercise can reduce severity of breast cancer treatment side effects

Radiotherapy has emerged as an important component of breast cancer treatment but can lead to cancer-related fatigue and negatively impact patients' health-related quality of life. Research has revealed exercise may make the treatment more tolerable for patients.

from Breast Cancer News -- ScienceDaily https://ift.tt/TXLFID7

Newly developed gene classifier identifies risk of pre-breast cancer progression

Researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) have made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.

from Breast Cancer News -- ScienceDaily https://ift.tt/rTszfxk

Nanotechnology platform enables immune conversion of cancer cells, sensitizing them to immunotherapy

A team of researchers has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy. The preclinical findings suggest this adaptable immune conversion approach has the potential for broad application across many cancer types.

from Breast Cancer News -- ScienceDaily https://ift.tt/fyUoLVI

Breast cancer spread uncovered by new molecular microscopy

Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumor may be the key to controlling the spread of disease.

from Breast Cancer News -- ScienceDaily https://ift.tt/4XZBQkt

Breast cancer survivorship doubles

A study shows there are 2.5 times as many breast cancer survivors in Canada today as there were in 2007 -- a success story that brings some new health challenges.

from Women's Health News -- ScienceDaily https://ift.tt/NrSVROJ

Breast cancer survivorship doubles

A study shows there are 2.5 times as many breast cancer survivors in Canada today as there were in 2007 -- a success story that brings some new health challenges.

from Breast Cancer News -- ScienceDaily https://ift.tt/NrSVROJ

Anthropologists find new ways female bones are permanently altered after giving birth

Reproduction permanently alters females' bones in ways not previously known, a team of anthropologists has found. Its discovery, based on an analysis of primates, sheds new light on how giving birth can permanently change the body.

from Women's Health News -- ScienceDaily https://ift.tt/TawnfXq

Anthropologists find new ways female bones are permanently altered after giving birth

Reproduction permanently alters females' bones in ways not previously known, a team of anthropologists has found. Its discovery, based on an analysis of primates, sheds new light on how giving birth can permanently change the body.

from Women's Health News -- ScienceDaily https://ift.tt/TawnfXq

Stem cell-derived organoids mimic human parathyroid tissue

Patient-derived parathyroid organoids (PTOs) could pave the way for future physiology studies and drug-screening applications, as shown in a new study.

from Women's Health News -- ScienceDaily https://ift.tt/gT6Ul2m

Stem cell-derived organoids mimic human parathyroid tissue

Patient-derived parathyroid organoids (PTOs) could pave the way for future physiology studies and drug-screening applications, as shown in a new study.

from Women's Health News -- ScienceDaily https://ift.tt/gT6Ul2m

Some breast cancer patients with high responses to chemotherapy may not need surgery

Patients with early-stage breast cancer who had a pathologic complete response (pCR) to neoadjuvant chemotherapy may be able to skip surgery and receive standard radiation treatment with a low chance of disease recurrence, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/ipS4xRC

Researchers develop 'Goldilocks drug' to treat triple-negative breast cancer

Researchers have developed a drug that so specifically targets a deadly kind of breast cancer that there are little to no toxic side effects. Next, it will be tested in phase 1 clinical trials in humans.

from Women's Health News -- ScienceDaily https://ift.tt/phSwts9

Researchers develop 'Goldilocks drug' to treat triple-negative breast cancer

Researchers have developed a drug that so specifically targets a deadly kind of breast cancer that there are little to no toxic side effects. Next, it will be tested in phase 1 clinical trials in humans.

from Women's Health News -- ScienceDaily https://ift.tt/phSwts9

Scientists pinpoint druggable target in aggressive breast cancer

Researchers have set their sights on a new therapeutic target for an aggressive form of breast cancer with limited treatment options. Through a comprehensive and cutting-edge genomic screening method known as CRISPR/CAS9 screening, scientists were able to identify a specific enzyme called UBA1 that revealed itself as an ideal therapeutic target. Using a novel UBA-inhibiting drug called TAK-243, they blocked the cellular function of UBA1 and effectively killed cancer cells in patient-derived breast tumors in mice.

from Women's Health News -- ScienceDaily https://ift.tt/mdChF7e

How intermittent fasting affects female hormones

Intermittent fasting has been shown to be an effective way to lose weight, but critics have worried that the practice may have a negative impact on women's reproductive hormones. Now, a team brings new evidence to the table.

from Women's Health News -- ScienceDaily https://ift.tt/Oz9x3AJ

How intermittent fasting affects female hormones

Intermittent fasting has been shown to be an effective way to lose weight, but critics have worried that the practice may have a negative impact on women's reproductive hormones. Now, a team brings new evidence to the table.

from Women's Health News -- ScienceDaily https://ift.tt/a3ItfE6

Earlier mammograms for women with family history of breast cancer may not be needed

A new study may prompt medical experts to rethink when to start mammograms for women who have a mother, sister or daughter diagnosed with breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/D7nc31q

Earlier mammograms for women with family history of breast cancer may not be needed

A new study may prompt medical experts to rethink when to start mammograms for women who have a mother, sister or daughter diagnosed with breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/D7nc31q

Earlier mammograms for women with family history of breast cancer may not be needed

A new study may prompt medical experts to rethink when to start mammograms for women who have a mother, sister or daughter diagnosed with breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/D7nc31q

Study sheds light on understudied breast cancer type

A multi-center analysis of patients with invasive lobular carcinoma, or ILC -- the second most common histological subtype of invasive breast cancer in the U.S. -- showed that, despite its prevalence, ILC is detected later and has worse outcomes than the predominant subtype of invasive breast cancer, known as invasive ductal carcinoma (IDC), or no special type.

from Women's Health News -- ScienceDaily https://ift.tt/oLYsp0y

Study sheds light on understudied breast cancer type

A multi-center analysis of patients with invasive lobular carcinoma, or ILC -- the second most common histological subtype of invasive breast cancer in the U.S. -- showed that, despite its prevalence, ILC is detected later and has worse outcomes than the predominant subtype of invasive breast cancer, known as invasive ductal carcinoma (IDC), or no special type.

from Women's Health News -- ScienceDaily https://ift.tt/oLYsp0y

Hair straightening chemicals associated with higher uterine cancer risk

Women who used chemical hair straightening products were at higher risk for uterine cancer compared to women who did not report using these products, according to a new study. The researchers found no associations with uterine cancer for other hair products that the women reported using, including hair dyes, bleach, highlights, or perms.

from Women's Health News -- ScienceDaily https://ift.tt/1y0sP72

Hair straightening chemicals associated with higher uterine cancer risk

Women who used chemical hair straightening products were at higher risk for uterine cancer compared to women who did not report using these products, according to a new study. The researchers found no associations with uterine cancer for other hair products that the women reported using, including hair dyes, bleach, highlights, or perms.

from Women's Health News -- ScienceDaily https://ift.tt/1y0sP72

Researchers 3D bioprint breast cancer tumors, treat them in groundbreaking study

Researchers have successfully 3D bioprinted breast cancer tumors and treated them in a breakthrough study to better understand the disease that is one of the leading causes of mortality worldwide.

from Breast Cancer News -- ScienceDaily https://ift.tt/yxBbvcu

Experimental treatment approach counters allergic asthma without weakening flu defenses

A new study found that blocking the action of calcium signals in immune cells counters the most common form of asthma without compromising the body's defenses against flu viruses.

from Women's Health News -- ScienceDaily https://ift.tt/FZfBNr8

Long-term study supports link between inflammation and cognitive problems in older breast cancer survivors

Higher levels of a key inflammatory marker were related to older breast cancer survivors reporting cognitive problems, researchers found in one of the first long-term efforts to examine the potential link between chronic inflammation and cognition in older breast cancer survivors.

from Women's Health News -- ScienceDaily https://ift.tt/saBd4NF

Long-term study supports link between inflammation and cognitive problems in older breast cancer survivors

Higher levels of a key inflammatory marker were related to older breast cancer survivors reporting cognitive problems, researchers found in one of the first long-term efforts to examine the potential link between chronic inflammation and cognition in older breast cancer survivors.

from Women's Health News -- ScienceDaily https://ift.tt/saBd4NF

Unhealthy gut sets stage for breast cancer to spread, research reveals

An unhealthy gut triggers changes in normal breast tissue that helps breast cancer spread to other parts of the body, new research reveals.

from Women's Health News -- ScienceDaily https://ift.tt/engjD5k

Contrast-enhanced in-phase Dixon sequence impacts biopsy clip detection on breast MRI

Contrast-enhanced in-phase Dixon sequence could reduce the need for correlation among other imaging modalities to better identify areas of prior biopsy during breast MRI interpretation, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/t10FuL6

Technique developed in mice could aid detection of cancer in dense breasts

A two-pronged approach to imaging breast density in mice resulted in better detection of changes in breast tissue, including spotting early signs of cancer. The researchers hope that this approach will be translated from mice and improve breast imaging for people; it may also help with prognosis of disease as density can be linked to specific patterns of mammary gland growth, including signs of cancer development.

from Women's Health News -- ScienceDaily https://ift.tt/EzyQD9K

Technique developed in mice could aid detection of cancer in dense breasts

A two-pronged approach to imaging breast density in mice resulted in better detection of changes in breast tissue, including spotting early signs of cancer. The researchers hope that this approach will be translated from mice and improve breast imaging for people; it may also help with prognosis of disease as density can be linked to specific patterns of mammary gland growth, including signs of cancer development.

from Women's Health News -- ScienceDaily https://ift.tt/EzyQD9K

Specific sequence of drugs reduces cost of treating metastatic breast cancer while preserving quality of life

Researchers developed three different computer models to predict how a hypothetical set of 10,000 patients with specific types of metastatic breast cancer would respond to different sequences and types of chemotherapy. They determined that giving standard chemotherapy drugs in a specific sequence for some types of metastatic breast cancer can help reduce overall costs and improve the value of care while preserving quality of life.

from Breast Cancer News -- ScienceDaily https://ift.tt/GwBhIkt

Researchers identify a drug that mimics the effects of exercise on muscle and bone in mice

Researchers have developed a novel screening method to identify a drug that mimics the effects of exercise on muscle and bone. Locamidazole (LAMZ) improved muscle width and function and promoted bone formation while reducing bone resorption. LAMZ serves as a potential therapy for the treatment of locomotor diseases, such as sarcopenia and osteoporosis.

from Women's Health News -- ScienceDaily https://ift.tt/HDWo1IC

Researchers identify a drug that mimics the effects of exercise on muscle and bone in mice

Researchers have developed a novel screening method to identify a drug that mimics the effects of exercise on muscle and bone. Locamidazole (LAMZ) improved muscle width and function and promoted bone formation while reducing bone resorption. LAMZ serves as a potential therapy for the treatment of locomotor diseases, such as sarcopenia and osteoporosis.

from Women's Health News -- ScienceDaily https://ift.tt/HDWo1IC

Researchers map rotating spiral waves in live human hearts

Electrical signals tell the heart to contract, but when the signals form spiral waves, they can lead to dangerous cardiac events like tachycardia and fibrillation. Researchers are bringing a new understanding to these complicated conditions with the first high-resolution visualizations of stable spiral waves in human ventricles.

from Women's Health News -- ScienceDaily https://ift.tt/Pu1gNa8

Breast cancer cells use forces to open up channels through tissue

A new method reveals that cancer cells can spread by rapidly applying forces to tissue material.

from Women's Health News -- ScienceDaily https://ift.tt/W2Hc1hR

Researchers use nitric oxide 'scavengers' to target triple-negative breast cancer

Researchers are exploring a potential new therapeutic approach for triple negative breast cancer treatment. Medical researchers are working on the design of nitric oxide scavengers to form a new treatment approach for this aggressive form of breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/iTvLtWD

Fertility preservation measures do not appear to increase the risk of breast cancer recurrence

Women with a breast cancer diagnosis undergoing procedures for fertility preservation are not at increased risk of recurrence of the disease or disease-specific mortality. This has been shown in a study that followed the participants for five years on average. The results could in the future provide safety and new hope to women who want to preserve their fertility after cancer treatment with chemotherapy.

from Breast Cancer News -- ScienceDaily https://ift.tt/Xv197sU

Fertility preservation measures do not appear to increase the risk of breast cancer recurrence

Women with a breast cancer diagnosis undergoing procedures for fertility preservation are not at increased risk of recurrence of the disease or disease-specific mortality. This has been shown in a study that followed the participants for five years on average. The results could in the future provide safety and new hope to women who want to preserve their fertility after cancer treatment with chemotherapy.

from Women's Health News -- ScienceDaily https://ift.tt/Xv197sU

Fertility preservation measures do not appear to increase the risk of breast cancer recurrence

Women with a breast cancer diagnosis undergoing procedures for fertility preservation are not at increased risk of recurrence of the disease or disease-specific mortality. This has been shown in a study that followed the participants for five years on average. The results could in the future provide safety and new hope to women who want to preserve their fertility after cancer treatment with chemotherapy.

from Women's Health News -- ScienceDaily https://ift.tt/Xv197sU

Researcher looks at molecular changes for clues to disparities in breast cancer outcomes

It’s a figure that stands out. Black women have a 36% higher breast cancer mortality rate than other races in spite of having a similar incidence to White women. Black women also are both more likely to be diagnosed with breast cancer at a younger age than White women and have double the rate of the aggressive, harder-to-treat triple negative breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/1cuIxAs

Researcher looks at molecular changes for clues to disparities in breast cancer outcomes

It’s a figure that stands out. Black women have a 36% higher breast cancer mortality rate than other races in spite of having a similar incidence to White women. Black women also are both more likely to be diagnosed with breast cancer at a younger age than White women and have double the rate of the aggressive, harder-to-treat triple negative breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/1cuIxAs

Researcher looks at molecular changes for clues to disparities in breast cancer outcomes

It’s a figure that stands out. Black women have a 36% higher breast cancer mortality rate than other races in spite of having a similar incidence to White women. Black women also are both more likely to be diagnosed with breast cancer at a younger age than White women and have double the rate of the aggressive, harder-to-treat triple negative breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/1cuIxAs

Proteins in cell-based particles could lead to early diagnosis and treatment of breast cancer metastasis

Researchers found that particles which are secreted by tumor cells, extracellular vesicles (EVs), displayed a high level of protein integrins alpha-v and beta-1, in patients with locally advanced and metastatic breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/Y3Dld9C

Proteins in cell-based particles could lead to early diagnosis and treatment of breast cancer metastasis

Researchers found that particles which are secreted by tumor cells, extracellular vesicles (EVs), displayed a high level of protein integrins alpha-v and beta-1, in patients with locally advanced and metastatic breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/Y3Dld9C

Vegetarian women are at a higher risk of hip fracture

A study of over 26,000 middle-aged UK women reveals those with a vegetarian diet had a 33% higher risk of hip fracture compared to regular meat-eaters.

from Women's Health News -- ScienceDaily https://ift.tt/DQJcF8m

Vegetarian women are at a higher risk of hip fracture

A study of over 26,000 middle-aged UK women reveals those with a vegetarian diet had a 33% higher risk of hip fracture compared to regular meat-eaters.

from Women's Health News -- ScienceDaily https://ift.tt/DQJcF8m

Study shows annual screening before age 50 leads to lower proportions of advanced breast cancer

A new study has found Canadian provinces that annually screen women aged 40-49 had lower proportions of advanced breast cancer compared to women aged 50-59 from provinces that did not hold annual mammograms.

from Women's Health News -- ScienceDaily https://ift.tt/qHaFz0J

A heat-sensitive calcium channel gets positive feedback

A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers excessive calcium release from the endoplasmic reticulum. Clarifying the mechanism by which calcium release is accelerated at an elevated temperature in patients with malignant hyperthermia may also provide important insight into how exertional heat stroke occurs under extreme environmental conditions.

from Women's Health News -- ScienceDaily https://ift.tt/onZP4V8

A heat-sensitive calcium channel gets positive feedback

A team of researchers has found that mutations in the calcium channel protein RyR1 that confer susceptibility to malignant hyperthermia make the protein hypersensitive to heat, which triggers excessive calcium release from the endoplasmic reticulum. Clarifying the mechanism by which calcium release is accelerated at an elevated temperature in patients with malignant hyperthermia may also provide important insight into how exertional heat stroke occurs under extreme environmental conditions.

from Women's Health News -- ScienceDaily https://ift.tt/onZP4V8

New model can predict best drug combinations for osteoporosis

Scientists have developed a new mathematical model that may help clinicians decide on the best combination of osteoporosis medications for patients and the order in which they should be taken.

from Women's Health News -- ScienceDaily https://ift.tt/cAeHnSU

Scientists identify novel molecular biomarkers in cells that spread a deadly form of breast cancer

Studying a deadly type of breast cancer called triple negative, scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors.

from Women's Health News -- ScienceDaily https://ift.tt/Nu8dHQb

Diets higher in calcium and potassium may help prevent recurrent symptomatic kidney stones

Kidney stones can cause not only excruciating pain but also are associated with chronic kidney disease, osteoporosis and cardiovascular disease. If you've experienced a kidney stone once, you have a 30% chance of having another kidney stone within five years.

from Women's Health News -- ScienceDaily https://ift.tt/fTWOK9e

Informing children of a mother's genetic cancer risk does not impact their health behaviors, study finds

Telling a child about their mother's risk of hereditary breast and ovarian cancer does not adversely influence the offspring's lifestyle or quality of life in the long term, according to a new study.

from Breast Cancer News -- ScienceDaily https://ift.tt/dGaptTk

Researchers develop liquid biopsy technique to help detect cancer in blood

Researchers have found a new way to track metastatic cancer cells in the body, which in the future could help identify cancer earlier and give patients more treatment options.

from Breast Cancer News -- ScienceDaily https://ift.tt/2fGrW7m

Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds

Inducing programmed cell death (PCD), such as apoptosis, is a widely used therapeutic option for the treatment of cancer. Unfortunately, many cancer cells become resistant to PCDs, and continue multiplying. In a new study, researchers have synthesized new complex-hybrid compounds named triptycene-peptide hybrids (TPHs), which successfully induced a kind of PCD known as paraptosis in Jurkat cells - -a type of lymphocytes. These paraptosis-inducing compounds may revolutionize cancer therapy in the future.

from Women's Health News -- ScienceDaily https://ift.tt/AhrQ8bP

Programmed cell death in cancer cells: Overcoming resistance through paraptosis-inducing compounds

Inducing programmed cell death (PCD), such as apoptosis, is a widely used therapeutic option for the treatment of cancer. Unfortunately, many cancer cells become resistant to PCDs, and continue multiplying. In a new study, researchers have synthesized new complex-hybrid compounds named triptycene-peptide hybrids (TPHs), which successfully induced a kind of PCD known as paraptosis in Jurkat cells - -a type of lymphocytes. These paraptosis-inducing compounds may revolutionize cancer therapy in the future.

from Women's Health News -- ScienceDaily https://ift.tt/AhrQ8bP

The effect of breast cancer screening is declining

A new research result questions whether the benefits of breast cancer screenings has gradually declined to a degree that it is too small in relation to the costs in the form of overdiagnosis and overtreatment.

from Women's Health News -- ScienceDaily https://ift.tt/K6Jn5yx

The effect of breast cancer screening is declining

A new research result questions whether the benefits of breast cancer screenings has gradually declined to a degree that it is too small in relation to the costs in the form of overdiagnosis and overtreatment.

from Breast Cancer News -- ScienceDaily https://ift.tt/K6Jn5yx

The effect of breast cancer screening is declining

A new research result questions whether the benefits of breast cancer screenings has gradually declined to a degree that it is too small in relation to the costs in the form of overdiagnosis and overtreatment.

from Women's Health News -- ScienceDaily https://ift.tt/K6Jn5yx

'Structural racism' cited in study of breast-biopsy delays

Black and Asian women are more likely than white women to experience significant delays in getting breast biopsies after a mammogram identifies an abnormality. Moreover, those delays appear to be influenced by screening site-specific factors that may stem from structural racism, according to new research.

from Women's Health News -- ScienceDaily https://ift.tt/Jhk5vEo

Hormones contribute to sex disparities in bladder cancer, study shows

Male sex hormones interfere with the body's ability to fight bladder cancer, likely explaining why males experience higher cancer rates and more deadly disease, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/mRCqSpJ

Hormones contribute to sex disparities in bladder cancer, study shows

Male sex hormones interfere with the body's ability to fight bladder cancer, likely explaining why males experience higher cancer rates and more deadly disease, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/mRCqSpJ

Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability

A compound called ERX-41 targets a previously unrecognized vulnerability in difficult-to-treat types of cancer including triple-negative breast cancer. The compound will be studied as a drug for clinical translation.

from Breast Cancer News -- ScienceDaily https://ift.tt/us3NwyM

Promising compound kills range of hard-to-treat cancers by targeting a previously undiscovered vulnerability

A compound called ERX-41 targets a previously unrecognized vulnerability in difficult-to-treat types of cancer including triple-negative breast cancer. The compound will be studied as a drug for clinical translation.

from Women's Health News -- ScienceDaily https://ift.tt/us3NwyM

Hormonal changes during menopause are directly related to decline in cardiovascular health

Levels of bad cholesterol rise during menopause, and 10% of this increase is likely due to shifts in sex hormones. Women usually undergo menopause at the age of 48 to 52 years, leading to a decline in estrogen and increase in follicle-stimulating hormone (FSH). Menopause is thought to predispose women to heart disease since it typically develops 10 years later than in men, and risk rises after menopause.

from Women's Health News -- ScienceDaily https://ift.tt/9IMgn8N

Great progress thanks to mini organs

Life-like organ replicas -- so-called 3D organoids -- are a good way to research disease processes. A team has now presented a kind of blueprint for such a model of the cervix.

from Women's Health News -- ScienceDaily https://ift.tt/GJdKjLY

Stress may be associated with fertility issues in women

Female rats exposed to a scream sound may have diminished ovarian reserve and reduced fertility, according to a small animal study.

from Women's Health News -- ScienceDaily https://ift.tt/eoZDdJp

Scientists discover how salt in tumors could help diagnose and treat breast cancer

Researchers have developed a technique using sodium magnetic resonance imaging (MRI) to detect salt levels in breast cancer tumors in mice. Imaging salt levels could be a vital new tool to help diagnose and monitor breast cancer, the researchers say.

from Breast Cancer News -- ScienceDaily https://ift.tt/32MrK8L

Reprogrammed macrophages promote spread of breast cancer

Metastatic breast cancer cells abuse macrophages, a type of immune cell, to promote the settlement of cancer metastases in the lungs. The reprogrammed macrophages stimulate blood vessel cells to secrete a cocktail of metastasis-promoting proteins that are part of the so-called metastatic niche.

from Breast Cancer News -- ScienceDaily https://ift.tt/keGsDzO

Breast cancer: Why metastasis spreads to the bone

When cancer cells break away from a primary tumor and migrate to other organs, this is called 'metastatic cancer.' The organs affected by these metastases, however, depend in part on their tissue of origin. In the case of breast cancer, they usually form in the bones.

from Women's Health News -- ScienceDaily https://ift.tt/cUfWm7F

Study finds infertility history linked with increased risk of heart failure

A woman's reproductive history can help predict her future risk of heart disease.

from Women's Health News -- ScienceDaily https://ift.tt/JRH1sQA

Obesity significantly increased heart failure risk among women with late menopause

While women who enter menopause before age 45 are known to be at higher risk of heart failure, obesity significantly increased heart failure risk among women who experienced late menopause -- at age 55 or older, according to a new study. The findings indicate that maintaining a healthy weight and avoiding abdominal obesity may protect against developing heart failure, especially among women who experience late menopause.

from Women's Health News -- ScienceDaily https://ift.tt/eBRhqJZ

Obesity significantly increased heart failure risk among women with late menopause

While women who enter menopause before age 45 are known to be at higher risk of heart failure, obesity significantly increased heart failure risk among women who experienced late menopause -- at age 55 or older, according to a new study. The findings indicate that maintaining a healthy weight and avoiding abdominal obesity may protect against developing heart failure, especially among women who experience late menopause.

from Women's Health News -- ScienceDaily https://ift.tt/eBRhqJZ

Antibiotic and antiretroviral drug effects on breast milk are explored for mothers living with HIV

Infants carry a vast assemblage of bacteria, viruses and fungi in their guts. Combined, these microbes make up a complex ecology known as the gut microbiome, which plays a major role in health and disease throughout life. The initial source of these billions of microbes is the mother's breast milk. Scientists have now used next-generation sequencing to investigate the breast milk microbiome from HIV positive women in Kenya.

from Breast Cancer News -- ScienceDaily https://ift.tt/WHlM5Ld

Antibiotic and antiretroviral drug effects on breast milk are explored for mothers living with HIV

Infants carry a vast assemblage of bacteria, viruses and fungi in their guts. Combined, these microbes make up a complex ecology known as the gut microbiome, which plays a major role in health and disease throughout life. The initial source of these billions of microbes is the mother's breast milk. Scientists have now used next-generation sequencing to investigate the breast milk microbiome from HIV positive women in Kenya.

from Women's Health News -- ScienceDaily https://ift.tt/WHlM5Ld

Reproductive factors and dementia risk

Pregnancy, long reproductive span, and older age at menopause are associated with a lower risk of dementia in women, according to a new study. Inversely, hysterectomy, younger age of first birth, and younger or older than average age at first period were associated with greater dementia risk.

from Women's Health News -- ScienceDaily https://ift.tt/BwPjSyK

Reproductive factors and dementia risk

Pregnancy, long reproductive span, and older age at menopause are associated with a lower risk of dementia in women, according to a new study. Inversely, hysterectomy, younger age of first birth, and younger or older than average age at first period were associated with greater dementia risk.

from Women's Health News -- ScienceDaily https://ift.tt/BwPjSyK

Levels of a certain hormone could predict or detect bone loss in premenopausal women

Physicians may be able to determine if menopause-related bone loss is already in progress or about to begin by measuring the level of a hormone called anti-Mullerian hormone that declines as women approach their final menstrual period. The findings could help physicians determine when, and how, to treat bone loss in women as they age before that bone loss causes significant health issues.

from Women's Health News -- ScienceDaily https://ift.tt/fOHzidh

Levels of a certain hormone could predict or detect bone loss in premenopausal women

Physicians may be able to determine if menopause-related bone loss is already in progress or about to begin by measuring the level of a hormone called anti-Mullerian hormone that declines as women approach their final menstrual period. The findings could help physicians determine when, and how, to treat bone loss in women as they age before that bone loss causes significant health issues.

from Women's Health News -- ScienceDaily https://ift.tt/fOHzidh

Viral transformations in the female genital tract can spell trouble for women’s health

A new study uses next-generation gene sequencing to get a clearer read on the community of viruses present in vaginal microbiome samples and its implication for the development of cervical cancer.

from Women's Health News -- ScienceDaily https://ift.tt/MnFcRxG

Viral transformations in the female genital tract can spell trouble for women’s health

A new study uses next-generation gene sequencing to get a clearer read on the community of viruses present in vaginal microbiome samples and its implication for the development of cervical cancer.

from Women's Health News -- ScienceDaily https://ift.tt/MnFcRxG

The surprising diversity of the fallopian tube

A new study creates a detailed 'atlas' of the various cell types and their gene activities within the highly specialized fallopian tube, paving the way for new research into infertility and other diseases affecting this organ, including some cancers.

from Women's Health News -- ScienceDaily https://ift.tt/wbBUzsh

The surprising diversity of the fallopian tube

A new study creates a detailed 'atlas' of the various cell types and their gene activities within the highly specialized fallopian tube, paving the way for new research into infertility and other diseases affecting this organ, including some cancers.

from Women's Health News -- ScienceDaily https://ift.tt/wbBUzsh

Working shifts may delay the onset of menopause

It's no secret that working nontraditional shifts can wreak havoc on lifestyle and sleep habits. Shift work has also been known to have a negative effect on workers' health. A new study suggests it also may delay the onset of natural menopause, possibly because of disruptions in circadian rhythms.

from Women's Health News -- ScienceDaily https://ift.tt/0zMGwhE

Limiting energy in neurons exacerbates epilepsy

Epilepsy, one of the most common neurological disorders, is characterized by the spontaneous repetition of seizures caused by the hyperactivity of a group of neurons in the brain. Could we therefore reduce neuronal hyperactivity, and treat epilepsy, by reducing the amount of energy supplied to neurons and necessary for their proper functioning? Researchers discovered that, in mice, the seizures were actually exacerbated.

from Women's Health News -- ScienceDaily https://ift.tt/ofK7Mk5

New findings suggest that ‘one size does not fit all’ with regard to breast density education

Breast density notifications aim to educate women about the risks of high breast density, defined as having more fibroglandular tissue than fatty tissue, as visualized on a mammogram. Prompted by activists whose own breast density had obscured breast cancers on their mammograms, 38 U.S. states and Washington, DC, have enacted legislation requiring written notification of a patient's breast density (DBN) after a mammogram and language for a federal notification is forthcoming from the U.S.A. Food and Drug Administration. Yet, these notifications were developed with limited input and without extensive testing among women in the general population, and many are written at a high literacy level, often discordant with population literacy levels.

from Breast Cancer News -- ScienceDaily https://ift.tt/ik3KHQO

New findings suggest that ‘one size does not fit all’ with regard to breast density education

Breast density notifications aim to educate women about the risks of high breast density, defined as having more fibroglandular tissue than fatty tissue, as visualized on a mammogram. Prompted by activists whose own breast density had obscured breast cancers on their mammograms, 38 U.S. states and Washington, DC, have enacted legislation requiring written notification of a patient's breast density (DBN) after a mammogram and language for a federal notification is forthcoming from the U.S.A. Food and Drug Administration. Yet, these notifications were developed with limited input and without extensive testing among women in the general population, and many are written at a high literacy level, often discordant with population literacy levels.

from Women's Health News -- ScienceDaily https://ift.tt/ik3KHQO

Study identifies new protection mechanism in breast cancer

Researchers have identified a protein that protects against breast tumor growth and that can be linked to a better prognosis in breast cancer patients. The results may contribute to the development of new therapies for difficult-to-treat forms of breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/7P2JN8v

Study identifies new protection mechanism in breast cancer

Researchers have identified a protein that protects against breast tumor growth and that can be linked to a better prognosis in breast cancer patients. The results may contribute to the development of new therapies for difficult-to-treat forms of breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/7P2JN8v

Study identifies new protection mechanism in breast cancer

Researchers have identified a protein that protects against breast tumor growth and that can be linked to a better prognosis in breast cancer patients. The results may contribute to the development of new therapies for difficult-to-treat forms of breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/7P2JN8v

Radical increase in the effectiveness of breast cancer immunotherapy

Researchers have discovered the essential role of a new factor, LCOR, in enabling cancer cells to present tumor antigens on their surfaces. These antigens allow the immune system to recognize the tumor, an essential step if immunotherapy treatment is to succeed. On the other hand, they have shown that cancer stem cells have very low levels of LCOR, making them invisible to the immune system and therefore resistant to treatment.

from Breast Cancer News -- ScienceDaily https://ift.tt/13dESDj

Long-suspected turbocharger for memory found in brain cells of mice

Scientists have long known that learning requires the flow of calcium into and out of brain cells. But researchers have now discovered that floods of calcium originating from within neurons can also boost learning. The finding emerged from studies of how mice remember new places they explore.

from Women's Health News -- ScienceDaily https://ift.tt/tWPXrVn

AI provides accurate breast density classification

An artificial intelligence (AI) tool can accurately and consistently classify breast density on mammograms, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/DgWQZjL

AI provides accurate breast density classification

An artificial intelligence (AI) tool can accurately and consistently classify breast density on mammograms, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/DgWQZjL

Molecular networks could explain racial disparity in triple negative breast cancer deaths

Different activity in two molecular networks could help explain why triple negative breast cancers tend to be more aggressive in African American (AA) women compared with white American (WA) women, a new study suggests.

from Women's Health News -- ScienceDaily https://ift.tt/skqS2ur

Researchers identify misperceptions surrounding breast density across race/ethnicity and health literacy levels

Having dense breasts (more fibroglandular tissue than fatty tissue, as visualized on a mammogram) reduces the sensitivity of mammography by masking breast cancers and carries a 1.6- to 2.0-fold increased independent risk for breast cancer. To inform women about these risks, 38 U.S. states and the federal government have enacted legislation requiring a written dense breast notification (DBN) of a patient's breast density after a mammogram, but there still is limited evidence about what breast density means, and what the implications are, to women. According to a new study, while women are receiving these notifications about their breast density, not all recipients are fully understanding what they mean in terms of future health implications. Boston University School of Medicine researchers suggest that knowledge about breast density and its associated risks is partly linked to women's race/ethnicity and health literacy.

from Women's Health News -- ScienceDaily https://ift.tt/WK7bJSf

In pilot study, asynchronous telehealth visits effectively treat overactive bladder

Women with overactive bladder are frequently frustrated with treatment, which leads to discontinuation of therapy. Asynchronous telehealth visits keep women engaged in follow-up care, accelerates trials of different medications and reinforces behavioral changes. The women in this pilot study reported improvement in symptoms and high satisfaction with asynchronous visits.

from Women's Health News -- ScienceDaily https://ift.tt/1oiTgxv

Early menopause may raise risk of dementia later in life

Compared with women who enter menopause around age 50, women who experience very early menopause (before the age of 40) were found to be 35% more likely to develop some type of dementia later in life, according to a large study of women living in the United Kingdom. Women who entered menopause before age 45 were also 1.3 times more likely to develop dementia before the age of 65. In addition, women who entered menopause later, at age 52 or older, had dementia risk similar to women who entered menopause at the average age for menopause onset which is the age of 50 to 51 years.

from Women's Health News -- ScienceDaily https://ift.tt/QYWas9u

Obesity may lead to a decline in lung function in premenopausal and postmenopausal women

Obesity has been linked to a wide array of health problems. A new study suggests that abdominal obesity as measured by body mass index (BMI) and waist circumference, may result in a greater risk of chronic obstructive pulmonary disease (COPD) and asthma.

from Women's Health News -- ScienceDaily https://ift.tt/2JKp8e7

Obesity may lead to a decline in lung function in premenopausal and postmenopausal women

Obesity has been linked to a wide array of health problems. A new study suggests that abdominal obesity as measured by body mass index (BMI) and waist circumference, may result in a greater risk of chronic obstructive pulmonary disease (COPD) and asthma.

from Women's Health News -- ScienceDaily https://ift.tt/2JKp8e7

How the immune system responds to tissue damage can aid cancer spread

Researchers have uncovered how a process involved in the regeneration of tissue damaged by radiation can aid the spread of cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/mR4tiJB

High CAC, high cholesterol increase heart attack/stroke risk, cardiologists find

Patients with both a high lipoprotein(a) and high coronary artery calcium score (CAC) face a more than 20% risk of heart attack or stroke over the following 10 years, according to findings from a multicenter study led by preventive cardiologists.

from Women's Health News -- ScienceDaily https://ift.tt/mKqWVHl

High CAC, high cholesterol increase heart attack/stroke risk, cardiologists find

Patients with both a high lipoprotein(a) and high coronary artery calcium score (CAC) face a more than 20% risk of heart attack or stroke over the following 10 years, according to findings from a multicenter study led by preventive cardiologists.

from Women's Health News -- ScienceDaily https://ift.tt/mKqWVHl

MRI may lower breast cancer deaths from variants in 3 genes

Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a comparative modeling analysis. The predictions involve pathogenic variants in ATM, CHEK2 and PALB2 genes -- which collectively are as prevalent as the much-reported BRCA1/2 gene mutations.

from Breast Cancer News -- ScienceDaily https://ift.tt/LJWt6cV

Pandemic upends breast cancer diagnoses

Researchers surveyed and compared early- and late-stage breast and colorectal cancer diagnoses in patients in pre-pandemic 2019 and in 2020, the first full year of the COVID-19 pandemic, discovering fewer of the former and more of the latter as patients delayed care.

from Breast Cancer News -- ScienceDaily https://ift.tt/EdQlWft

Men with high levels of body fat may be at risk for osteoporosis

Men with high levels of body fat have lower bone density and may be more likely to break a bone than those with normal levels of body fat, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/j9VF63C

Eating prunes may help protect against bone loss in older women

Researchers found that prunes can help prevent or delay bone loss in postmenopausal women, possibly due to their ability to reduce inflammation and oxidative stress, both of which contribute to bone loss.

from Women's Health News -- ScienceDaily https://ift.tt/fPa8mxQ

Potential target for treating osteoporosis

Channels on the surface of bone cells called osteocytes help build stronger bones in response to mechanical stress, shows a new study.

from Women's Health News -- ScienceDaily https://ift.tt/yYrMXzw

Glaucoma: Seeing the light at the end of the (nano)tunnel

A research team reveals the fine mechanisms behind the major vascular defects observed in glaucoma patients and identifies new therapeutic targets.

from Women's Health News -- ScienceDaily https://ift.tt/1IpknDb

Glaucoma: Seeing the light at the end of the (nano)tunnel

A research team reveals the fine mechanisms behind the major vascular defects observed in glaucoma patients and identifies new therapeutic targets.

from Women's Health News -- ScienceDaily https://ift.tt/1IpknDb

New path to treat advanced triple-negative breast cancer

A new study shows inhibition of the CECR2 gene prevents triple-negative breast cancer from advancing or metastasizing.

from Women's Health News -- ScienceDaily https://ift.tt/6gcXUt0p3

Obesity may increase risk of some female reproductive disorders

Obesity is associated with an increased risk of developing female reproductive disorders, however, the roles and mechanisms of obesity in the cause(s) of reproductive conditions are unclear. A study suggests an etiological link between obesity and a range of female reproductive conditions, but the extent of this link differs among conditions.

from Women's Health News -- ScienceDaily https://ift.tt/G9PayRebl

Researchers discover new way to target secondary breast cancer that has spread to the brain

A study has revealed a potential new way to treat secondary breast cancer that has spread to the brain, using existing drugs.

from Women's Health News -- ScienceDaily https://ift.tt/3ADb7Gd

Live cells discovered in human breast milk could aid breast cancer research

Researchers have explored the cellular changes that occur in human mammary tissue in lactating and non-lactating women, offering insight into the relationship between pregnancy, lactation, and breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/3G5Xgcp

Antibody with engineered peptide targets bone metastasis

A moderate amount of a peptide-enhanced cancer drug goes a long way in treating breast cancers that metastasize to the bone.

from Breast Cancer News -- ScienceDaily https://ift.tt/3tSNaJD

Antibody with engineered peptide targets bone metastasis

A moderate amount of a peptide-enhanced cancer drug goes a long way in treating breast cancers that metastasize to the bone.

from Women's Health News -- ScienceDaily https://ift.tt/3tSNaJD

Antibody with engineered peptide targets bone metastasis

A moderate amount of a peptide-enhanced cancer drug goes a long way in treating breast cancers that metastasize to the bone.

from Women's Health News -- ScienceDaily https://ift.tt/3tSNaJD

Calcium: Important not just for your bones but also for your heart

Researchers found a previously unknown gene mutation that can cause an incurable heart condition called dilated cardiomyopathy. This gene, BAC5, is important for the movement of calcium ions in the heart muscle and calcium ions are what drives the pumping of the heart. The good news is that the investigators also found a way to fix the mutation through a novel gene therapy approach, demonstrating a potential treatment for this devastating disease.

from Women's Health News -- ScienceDaily https://ift.tt/3fNrYfW

Calcium: Important not just for your bones but also for your heart

Researchers found a previously unknown gene mutation that can cause an incurable heart condition called dilated cardiomyopathy. This gene, BAC5, is important for the movement of calcium ions in the heart muscle and calcium ions are what drives the pumping of the heart. The good news is that the investigators also found a way to fix the mutation through a novel gene therapy approach, demonstrating a potential treatment for this devastating disease.

from Women's Health News -- ScienceDaily https://ift.tt/3fNrYfW

Vaccinated women pass COVID-19 antibodies to breastfeeding babies, study finds

Women vaccinated against COVID-19 transfer SARS-CoV-2 antibodies to their breastfed infants, potentially giving their babies passive immunity against the coronavirus, according to new research.

from Women's Health News -- ScienceDaily https://ift.tt/3ni8BPU

Researchers reduce breast cancer metastasis in animal models by modifying tumor electrical properties

Researchers have found that manipulating voltage patterns of tumor cells -- using ion channel blockers already FDA-approved as treatments for other diseases -- can in fact significantly reduce metastasis in animal models of breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/3GqQXkU