Give and take: Cancer chromosomes give the game away

As tumors develop, cancer cells gain and lose so-called 'chromosome arms', changing their response to drugs, a finding which may offer better personalized treatments for 17 types of cancer.

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The first roadmap for ovarian aging

Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear. Now, scientists have discovered, in unprecedented detail, how ovaries age in non-human primates. The findings reveal several genes that could be used as biomarkers and point to therapeutic targets for diagnosing and treating female infertility and age-associated ovarian diseases, such as ovarian cancer, in humans.

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PET/MRI identifies notable breast cancer imaging biomarkers

Researchers have identified several potentially useful breast cancer biomarkers that indicate the presence and risk of malignancy, according to new research.

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Breastfeeding and childbearing linked to lower early menopause risk

Results of a new epidemiological analysis of more than 108,000 women observed a lower risk of early menopause among women who had at least one pregnancy lasting at least six months and among those who had breastfed their infants. Further, risk was lowest among those who breastfed exclusively.

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Why eating yogurt may help lessen the risk of breast cancer

One of the causes of breast cancer may be inflammation triggered by harmful bacteria suggest researchers. Scientists advise consuming natural yogurt, which contains beneficial bacteria which dampens inflammation and which is similar to the bacteria found in breastfeeding mothers. Their suggestion is that this bacteria is protective because breast feeding reduces the risk of breast cancer. The consumption of yogurt is also associated with a reduction in the risk of breast cancer.

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Editing RNA delivers precision strike on triple-negative breast cancer

An abundance of microRNA-21 predicts lower survival in people with hard-to-treat 'triple-negative' breast cancer. An innovative compound targets the oncogenic sequence and removes it, killing the cancer cells and stopping their spread in a mouse model, while leaving healthy cells untouched.

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Blood tests can predict timing of final menstrual period

Blood tests could replace menstrual periods as a gauge for when a women is nearing menopause, according to new research.

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Two-drug combo halts the growth of cancer cells

Researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

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Missing link in mechanisms underlying fight-or-flight response

We've all felt the effects of an adrenaline rush. Faced with danger, real or perceived, the heart beats faster, breathing quickens and muscles tighten as the body prepares to fight a threat or flee from it.

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Refining breast cancer classification by multiplexed imaging

An imaging approach enables the study of breast cancer tissue in greater detail. It uses 35 biomarkers to identify the different cell types in breast tumors and its surrounding area compared to the current standard of testing single markers. This increases the precision of tumor analysis and classification - and improves personalized diagnostics for breast cancer patients.

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Hot flashes impair memory performance

If you're having difficulty identifying the right word to express yourself clearly or remembering a story correctly, you may blame menopause. A new study suggests that physiologic hot flashes are associated with decreased verbal memory and with alterations in brain function during encoding and retrieval of memory, especially in the hippocampus and prefrontal cortex.

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Researchers discover novel potential target for drug addiction treatment

New research discovers a novel potential target for treating drug addiction through 'the hidden stars of the brain.'

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Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer

Activation of the BMP4 signalling pathway presents a new therapeutic strategy to combat metastatic breast cancer, a disease that has shown no reduction in patient mortality over the past 20 years.

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Acid reflux drugs may have negative side effects for breast cancer survivors

Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors' memory and concentration.

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Hormone resistance in breast cancer linked to DNA 'rewiring'

Researchers have revealed changes to the 3D arrangement of DNA linked to treatment resistance in ER+ breast cancer.

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Pulling the plug on calcium pumps -- potential new treatment strategy for pancreatic cancer

UK scientists have identified a new way to kill pancreatic cancer cells by 'pulling the plug' on the energy generator that fuels calcium pumps on their cell surface. The study reports how switching off the cancer's energy supply causes the pancreatic cancer cells to become 'poisoned' by an irreversible build-up of calcium.

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Study shows lactate may prompt cancer formation

A byproduct of glucose called lactate, used by every cell in the body, may also prompt a mutated cell to become cancerous, according to new research.

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DNA Damage to Breast Cells from chemicals in some cosmetics, sunscreens

A new approach to studying the effects of two common chemicals used in cosmetics and sunscreens found they can cause DNA damage in breast cells at surprisingly low concentrations, while the same dose did not harm cells without estrogen receptors.

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Having less sex linked to earlier menopause

Women who engage in sexual activity weekly or monthly have a lower risk of entering menopause early relative to those who report having some form of sex less than monthly, according to a new study.

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Genetic study provides most comprehensive map of risk to date of breast cancer risk

A major international study of the genetics of breast cancer has identified more than 350 DNA 'errors' that increase an individual's risk of developing the disease. The scientists involved say these errors may influence as many as 190 genes.

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Step toward 'ink' development for 3-D printing a bioprosthetic ovary

For the first time, scientists identified and mapped the location of structural proteins in a pig ovary. Ongoing development of an 'ink' with these proteins will be used for 3-D printing an artificial (or bio-prosthetic) ovary that could be implanted and allow a woman to have a child.

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Starting point for designing drugs that cure clostridium difficile

A new article details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure C. diff -- a virulent health care-associated infection that causes severe diarrhea, nausea, internal bleeding, and potentially death.

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