New mammogram measures of breast cancer risk could revolutionize screening

World-first techniques for predicting breast cancer risk from mammograms could revolutionize breast screening by allowing it to be tailored to women at minimal extra cost.

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New mammogram measures of breast cancer risk could revolutionize screening

World-first techniques for predicting breast cancer risk from mammograms could revolutionize breast screening by allowing it to be tailored to women at minimal extra cost.

from Women's Health News -- ScienceDaily https://ift.tt/2KPQ1hQ

New mammogram measures of breast cancer risk could revolutionize screening

World-first techniques for predicting breast cancer risk from mammograms could revolutionize breast screening by allowing it to be tailored to women at minimal extra cost.

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Surgery may offer survival advantage in certain metastatic breast cancers

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to researchers.

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Surgery may offer survival advantage in certain metastatic breast cancers

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to researchers.

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Surgery may offer survival advantage in certain metastatic breast cancers

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to researchers.

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Nanotechnology: Nanoparticles as weapons against cancer

Researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors.

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Nanotechnology: Nanoparticles as weapons against cancer

Researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors.

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Can mammogram screening be more effective?

Economists have identified an important challenge in designing age-related guidelines for when to start breast cancer screenings: Women who start getting mammograms at age 40 may be healthier than the population of 40-year-old women as a whole, with a lower incidence of breast cancer at that age.

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Oral contraceptive pills protect against ovarian and endometrial cancer

A comprehensive study involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use.

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Oral contraceptive pills protect against ovarian and endometrial cancer

A comprehensive study involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use.

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Oral contraceptive pills protect against ovarian and endometrial cancer

A comprehensive study involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use.

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Immune cell that drives breast cancer could be effective target in novel immunotherapies

Researchers have identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease.

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Immune cell that drives breast cancer could be effective target in novel immunotherapies

Researchers have identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease.

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Immune cell that drives breast cancer could be effective target in novel immunotherapies

Researchers have identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease.

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Undruggable diseases gain a new RNA drug-discovery tool

A new RNA-targeting tool enables scientists to tackle difficult molecular recognition problems to aid drug discovery for incurable diseases.

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New insights about depression

New research reveals new insights about risk factors for depression based on data from a landmark longitudinal study focused on heart disease.

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New insights about depression

New research reveals new insights about risk factors for depression based on data from a landmark longitudinal study focused on heart disease.

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What makes hard workouts so effective

High-intensity interval training strengthens the heart even more than moderate exercise does. Now researchers have found several answers to what makes hard workouts so effective.

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What makes hard workouts so effective

High-intensity interval training strengthens the heart even more than moderate exercise does. Now researchers have found several answers to what makes hard workouts so effective.

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Promising treatment for premenstrual dysphoric disorder, PMDD

The mental symptoms of premenstrual dysphoric disorder improve following treatment with a progesterone receptor modulator. The mechanism of action of the study drug provides insights into the potential molecular mechanisms underlying this disorder and its treatment.

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Promising treatment for premenstrual dysphoric disorder, PMDD

The mental symptoms of premenstrual dysphoric disorder improve following treatment with a progesterone receptor modulator. The mechanism of action of the study drug provides insights into the potential molecular mechanisms underlying this disorder and its treatment.

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Breast cancer survivors are less likely to get pregnant, but often have healthy babies and good long-term health

A large meta-analysis of breast cancer survivors of childbearing age indicated that they are less likely than the general public to get pregnant, and they face higher risk of certain complications such as preterm labor. However, most survivors who do get pregnant deliver healthy babies and have no adverse effects on their long-term survival, according to new data.

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Breast cancer survivors are less likely to get pregnant, but often have healthy babies and good long-term health

A large meta-analysis of breast cancer survivors of childbearing age indicated that they are less likely than the general public to get pregnant, and they face higher risk of certain complications such as preterm labor. However, most survivors who do get pregnant deliver healthy babies and have no adverse effects on their long-term survival, according to new data.

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Breast cancer survivors are less likely to get pregnant, but often have healthy babies and good long-term health

A large meta-analysis of breast cancer survivors of childbearing age indicated that they are less likely than the general public to get pregnant, and they face higher risk of certain complications such as preterm labor. However, most survivors who do get pregnant deliver healthy babies and have no adverse effects on their long-term survival, according to new data.

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Key driver of the spread of cancer to the brain

Approximately 200,000 cancer patients are diagnosed with brain metastases each year, yet few treatment options exist because the mechanisms that allow cancer to spread to the brain remain unclear. However, a study offers hope for the development of future therapies by showing how a poorly understood gene known as YTHDF3 plays a significant role in the process.

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Can we make bones heal faster?

A new article describes for the first time how minerals come together at the molecular level to form bones and other hard tissues, like teeth and enamel.

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Drinking blocks a chemical that promotes attention

Scientists studied the cascade of events that begins when alcohol diminishes norepinephrine release in a brain structure called the locus coeruleus.

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Vitamin D regulates calcium in intestine differently than previously thought

A new study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation.

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Molecular 'barcode' helps decide which sperm will reach an egg

A protein called CatSper1 may act as a molecular 'barcode' that helps determine which sperm cells will make it to an egg and which are eliminated along the way.

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Study shows protective role sex steroids play in COVID-19

A new paper analyzes existing research to look at reasons why COVID-19 symptom severity and mortality are more frequent in men than in women and in older people. The research suggests female reproductive steroids play a protective role.

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Potential cellular target for eliminating bone breakdown in osteoporosis found

By disabling a function of a set of cells in mice, researchers appear to have halted the process that breaks down bone, a potential boon for osteoporosis treatment.

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How rotavirus causes severe gastrointestinal disease

Using intercellular calcium waves, rotavirus amplifies its ability to cause disease beyond the cells it directly infects. This is the first virus identified to activate ADP-mediated intercellular calcium waves.

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A DNA-based nanogel for targeted chemotherapy

Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers have designed DNA-based nanogels that only break down and release their chemotherapeutic contents within cancer cells, minimizing the impacts on normal ones and potentially eliminating painful and uncomfortable side effects.

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A more sensitive way to detect circulating tumor cells

Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients. Detecting circulating tumor cells (CTCs) in the bloodstream could help doctors find and treat metastases at an earlier stage, increasing chances of survival. Now, researchers have developed a method that could more sensitively detect CTCs within the complex environment of blood.

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A more sensitive way to detect circulating tumor cells

Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients. Detecting circulating tumor cells (CTCs) in the bloodstream could help doctors find and treat metastases at an earlier stage, increasing chances of survival. Now, researchers have developed a method that could more sensitively detect CTCs within the complex environment of blood.

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Existing antidepressant helps to inhibit growth of cancer cells in lab animals

New research has shown that the antidepressant sertraline helps to inhibit the growth of cancer cells. The substance acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and lab animals.

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'Rewiring' metabolism in insulin-producing cells may aid Type 2 diabetes treatment

Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop drugs for boosting insulin production in people with Type 2 diabetes.

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Study finds 1 in 8 patients with cancer harbor inherited genetic mutations

Genetic testing can uncover inherited genetic mutations, and could individualize cancer therapies, improve survival, manage cancer in loved ones and push the boundaries of precision medicine.

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Some of the principal treatments for osteoporosis could reduce the incidence of COVID-19, study finds

A new study suggests that certain drugs used to treat osteoporosis are safe for COVID-19 patients and could even have a protective effect. The results support the recommendations of the scientific guidelines relating to the desirability of maintaining treatments for osteoporosis in patients with COVID-19.

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Some of the principal treatments for osteoporosis could reduce the incidence of COVID-19, study finds

A new study suggests that certain drugs used to treat osteoporosis are safe for COVID-19 patients and could even have a protective effect. The results support the recommendations of the scientific guidelines relating to the desirability of maintaining treatments for osteoporosis in patients with COVID-19.

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Aspirin use best for those with high coronary calcium, low risk of bleeding

An X-ray test commonly used to assess hardening of the arteries could help doctors decide whether the benefits of taking aspirin to prevent a first heart attack or stroke outweigh the risks of bleeding from its use, research suggests.

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New estimates of breast cancer risks associated with HRT

A new study provides new estimates of the increased risks of breast cancer associated with use of different hormone replacement therapy (HRT) preparations.

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New estimates of breast cancer risks associated with HRT

A new study provides new estimates of the increased risks of breast cancer associated with use of different hormone replacement therapy (HRT) preparations.

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'Fast' MRI detects breast cancers that 3-D mammograms may miss

In a retrospective study of asymptomatic patients, all of whom had a negative 3-D mammogram within the previous 11 months, abbreviated MRI detected roughly 27 cancers per 1,000 women screened.

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'Fast' MRI detects breast cancers that 3-D mammograms may miss

In a retrospective study of asymptomatic patients, all of whom had a negative 3-D mammogram within the previous 11 months, abbreviated MRI detected roughly 27 cancers per 1,000 women screened.

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What do breast cancer cells feel inside the tumor?

Using a new technique, a team of researchers has found tiny and previously undetectable 'hot spots' of extremely high stiffness inside aggressive and invasive breast cancer tumors. Their findings suggest, for the first time, that only very tiny regions of a tumor need to stiffen for metastasis to take place. Though still in its infancy, the researchers believe that their technique may prove useful in detecting and mapping the progression of aggressive cancers.

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Over 80 percent of COVID-19 patients have vitamin D deficiency, study finds

Over 80 percent of 200 COVID-19 patients in a hospital in Spain have vitamin D deficiency, according to a new study.

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Steroid inhalers/pills for asthma linked to heightened risk of brittle bones and fractures

Taking steroid inhalers or tablets to treat asthma or control flare-ups is linked to a heightened risk of brittle bones (osteoporosis) and increased vulnerability to broken bones (fragility fractures), finds new research.

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The 'goldilocks day': The perfect day for kids' bone health

Not too little, not too much - Goldilocks' 'just right' approach can now assess children's daily activities as new research confirms the best make up of a child's day to maximize bone health and function in children.

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The 'goldilocks day': The perfect day for kids' bone health

Not too little, not too much - Goldilocks' 'just right' approach can now assess children's daily activities as new research confirms the best make up of a child's day to maximize bone health and function in children.

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Calcium bursts kill drug-resistant tumor cells

Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR.

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Skeletal muscle development and regeneration mechanisms vary by gender

Researchers have generated mice lacking the estrogen receptor beta gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ER-beta gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration.

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Novel discoveries in preventing epileptic seizures

Researchers have found that an amino acid produced by the brain could play a crucial role in preventing a type of epileptic seizure.

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Women's expected longevity linked to age at birth of last child

No one knows for sure how long they will live. A new study, however, suggests that leukocyte telomere length may offer some key insights into a woman's longevity and further demonstrates how maternal age at birth of last child affects telomere length and long-term health.

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How an egg cell's 'operating manual' sets the stage for fertility

Scientists have revealed in unprecedented detail the genetic instructions immature egg cells go through step by step as they mature into functionality. Their findings improve our understanding of how ovaries maintain a female's fertility.

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Light stimulation makes bones heavier

Researchers showed that laser ablation of bone inhibits expression of the osteogenesis inhibitor protein sclerostin without causing inflammation, unlike the conventional bur-drilling technique. Further investigations confirmed that this beneficial bio-stimulation works by inducing mechanical stress. These findings help advance research into the treatment of osteoporosis as well as specific enhancement of bone regrowth in orthopedic and dental surgery.

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Pregnancy complications linked to heightened risk of heart disease and stroke in later life

Pregnancy complications such as miscarriage, pre-eclampsia, diabetes in pregnancy (gestational diabetes) and pre-term birth are linked to a heightened risk of heart disease in later life, suggests an overarching (umbrella) analysis of data.

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New analytical model detects mutations in breast cancer

Researchers have developed a computational model which is effective in detecting and identifying genetic mutations in breast tumors. The study, the largest of its kind in the world, includes results from over 3,200 patients with breast cancer.

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Regulatory T cells could lead to new immunotherapies aimed at treating multiple sclerosis

Researchers have discovered how regulatory T cells (Treg) are instrumental in limiting the damage caused to the spinal cord in diseases like multiple sclerosis (MS).

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Blood vessel growth in muscle is reduced in women after menopause

A new study demonstrates that formation of small blood vessels is impaired in the muscle tissue of postmenopausal women. The study's findings highlight the importance of physical activity for women prior to and during menopause, as a means to prevent the development of disease later in life.

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'Trojan horse' approach to kill cancer cells without using drugs

Cancer cells are killed in lab experiments and tumor growth reduced in mice, using a new approach that turns a nanoparticle into a 'Trojan horse' that causes cancer cells to self-destruct.

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Higher dementia risk in women with prolonged fertility

Women with a longer reproductive period had an elevated risk for dementia in old age, compared with those who were fertile for a shorter period, a population-based study.

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Combining two precision medicines can treat drug-resistant cancers

Launching a dual-pronged attack on tumours using a combination of two innovative precision medicines could treat patients with multiple common cancers, a new clinical trial shows.

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Botox for TMJ disorders may not lead to bone loss in the short term, but more research is needed

Botox injections to manage jaw and facial pain do not result in clinically significant changes in jaw bone when used short term and in low doses, according to researchers. However, they found evidence of bone loss when higher doses were used.

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Stronger bones thanks to heat and microbiota

Osteoporosis is characterized by a deterioration of the bones and an increased risk of fractures. With one third of postmenopausal women affected, it is a major public health problem. A research team has observed that exposure to warmer ambient temperatures increases bone strength and prevents the loss of bone density. This phenomenon is linked to a change in the composition of gut microbiota and makes hopes for osteoporosis treatments.

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New way to target some rapidly dividing cancer cells, leaving healthy cells unharmed

Scientists say they have found a new way to kill some multiplying human breast cancer cells by selectively attacking the core of their cell division machinery.

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Women's heart health linked to age at first menstrual period

Early menarche has been associated with many cardiovascular disease (CVD) risk factors, but little is known about its association with overall heart health. One new study suggests that age at menarche plays an important role in maintaining and improving cardiovascular health, although there are a number of age differences.

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Brain astrocytes show metabolic alterations in Parkinson's disease

A new study using induced pluripotent stem cell (iPSC) technology links astrocyte dysfunction to Parkinson's disease (PD) pathology. The study highlights the role of brain astrocyte cells in PD pathology and the potential of iPSC-derived cells in disease modelling and drug discovery.

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Endometriosis: No cure, but diagnosis could avert surgery

176 million women worldwide who have endometriosis, a chronic, painful gynaecological condition. It affects nearly three times as many women as breast cancer.

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Personal use of permanent hair dye not associated with greater risk of most cancers or cancer death

Women who use permanent hair dye products to colour their hair at home do not experience greater risk of most cancers or greater cancer related mortality.

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Exposure to workplace sexual harassment linked to an increased risk of suicidal behavior

Workers who have been exposed to sexual harassment in their workplace are at greater risk of suicide and attempting suicide, a new study finds.

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Effective cancer immunotherapy further linked to regulating a cell 'suicide' gene

Researchers have added to evidence that a gene responsible for turning off a cell's natural 'suicide' signals may also be the culprit in making breast cancer and melanoma cells resistant to therapies that use the immune system to fight cancer.

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Cancer cells take over blood vessels to spread

In laboratory studies, researchers observed a key step in how cancer cells may spread from a primary tumor to a distant site within the body, a process known as metastasis.

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Venom from honeybees found to kill aggressive breast cancer cells

Honeybee venom induces cancer cell death in hard to treat triple-negative breast cancer with minimal effect on healthy cells, new research finds.

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Genetic mutations may be linked to infertility, early menopause

A new study identifies a specific gene's previously unknown role in fertility. When the gene is missing in fruit flies, roundworms, zebrafish and mice, the animals are infertile or lose their fertility unusually early but appear otherwise healthy. Analyzing genetic data in people, the researchers found an association between mutations in this gene and early menopause.

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Phase 1 human trials suggest breast cancer drug is safe, effective

A new type of breast cancer drug can help halt progression of disease and is not toxic, according to phase 1 clinical trials.

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Hip fracture risk linked to nanoscale bone inflexibility

New research has highlighted a preventative treatment gap in patients prone to bone fractures who are otherwise healthy.

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Researchers pinpoint hierarchy of breast cancer cells as potential cause for treatment resistance

Researchers say it can take cells in different forms or 'life stages' to cause cancer to grow and spread.

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New surgical approach for women at risk of ovarian cancer

A new two-stage surgical approach for cancer prevention is highly acceptable among premenopausal women at high risk of ovarian cancer.

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None of the most common blood pressure medications increased the risk of depression, some lowered the risk

Among the 41 most common blood pressure medications, none of them raised the risk of depression, according to an analysis from Denmark. The study also found that some high blood pressure medications lowered the risk of depression. These findings may help guide medical professionals in selecting the right hypertension medication, particularly for people with a personal or family history of depression.

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Single dose radiotherapy as good as conventional therapy for most women with early breast cancer

For most women with early breast cancer, a single dose of targeted radiotherapy during surgery is just as effective as conventional radiotherapy, which requires several visits to hospital after surgery, according to new findings.

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Single dose radiotherapy as good as conventional therapy for most women with early breast cancer

For most women with early breast cancer, a single dose of targeted radiotherapy during surgery is just as effective as conventional radiotherapy, which requires several visits to hospital after surgery, according to new findings.

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Broccoli and Brussels sprouts a cut above for blood vessel health

New research has shown some of our least favorite vegetables could be the most beneficial when it comes to preventing advanced blood vessel disease.

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High blood pressure during pregnancy may mean worse hot flashes during menopause

Women with a history of high blood pressure disorders during pregnancy are more likely to experience bothersome menopausal symptoms such as hot flashes and night sweats, according to a new study.

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Half of breast cancer survivors had delays in care due to COVID-19

The results of an online questionnaire of 609 breast cancer survivors in the US suggest that nearly half of patients experienced delays in care during the early weeks of the COVID-19 pandemic.

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New gene therapy approach eliminates at least 90% latent herpes simplex virus 1

Infectious disease researchers have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes. In animal models, the findings show at least a 90 percent decrease in the latent virus, enough researchers expect that it will keep the infection from coming back.

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Postmenopausal women at risk for nonalcoholic fatty liver disease, review suggests

A new review suggests that following menopause, women are at higher risk for developing nonalcoholic fatty liver disease (NAFLD), a chronic condition caused by the build-up of excess fat in the liver not caused by alcohol.

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Immunotherapy extends survival in mouse model of hard-to-treat breast cancer

Immunotherapies for cancer -- treatments that prime the immune system to attack tumors -- are valuable weapons in the anti-cancer arsenal. But some cancers are more difficult to target with this strategy than others. Today, scientists report a new immunotherapy that dramatically extends the survival of mice that have triple negative breast tumors, a difficult-to-treat form of cancer.

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Causes of higher risk of stress fractures in female runners

A pair of new studies identify overlooked physiological factors and lack of knowledge around wellness as contributors to risk of stress fracture in women who run.

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Vitamin D twice a day may keep vertigo away

Taking vitamin D and calcium twice a day may reduce your chances of getting vertigo again, according to a new study.

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New strategy against osteoporosis

An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.

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A new way to target cancers using 'synthetic lethality'

Researchers report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth.

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A new way to target cancers using 'synthetic lethality'

Researchers report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth.

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Antiviral method against herpes paves the way for combating incurable viral infections

Researchers have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. It does not lead to resistance and acts independently of mutations in the genome of the virus.

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Study finds global trends in women's breast cancer show cause for concern

Breast cancer rates among women globally are on the rise, but new research is uncovering trends related to age and where you live that could help target prevention measures to improve the situation.

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Study finds global trends in women's breast cancer show cause for concern

Breast cancer rates among women globally are on the rise, but new research is uncovering trends related to age and where you live that could help target prevention measures to improve the situation.

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Immune system -- Knocked off balance

Instead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies. A team has now dissected how mast cells regulate their calcium levels to keep the immune response under control.

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Triple negative breast cancer meets its match

One member of a larger family of oxygen sensing enzymes could offer a viable target for triple negative breast cancer (TNBC), researchers report in a new study. The findings might offer hope to this subset of patients who have few effective treatment options and often face a poor prognosis.

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Calcium channel subunits play a major role in autism spectrum disorders

Neurobiologists have found new evidence that specific calcium channel subunits play a crucial role in the development of excitatory and inhibitory synapses.

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Cancer metabolic pathway identified as target for therapy

Fighting cancer often means employing a suite of techniques to target the tumor and prevent it from growing and spreading to other parts of the body. It's no small feat -- the American Cancer Society predicts roughly 1.8 million new cases of cancer in the country in 2020, underscoring the need to identify additional ways to outsmart the runaway cells.

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Cancer metabolic pathway identified as target for therapy

Fighting cancer often means employing a suite of techniques to target the tumor and prevent it from growing and spreading to other parts of the body. It's no small feat -- the American Cancer Society predicts roughly 1.8 million new cases of cancer in the country in 2020, underscoring the need to identify additional ways to outsmart the runaway cells.

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Fasting diet could boost breast cancer therapy

A team of scientists has found that a fasting-mimicking diet combined with hormone therapy has the potential to help treat breast cancer, according to newly published animal studies and small clinical trials in humans.

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Early menstruation linked to increased menopause symptoms

Early menstruation increases the likelihood of hot flushes and nights sweats decades later at menopause, according to a new study.

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New nano drug candidate kills aggressive breast cancer cells

Researchers have developed a new drug candidate that kills triple negative breast cancer cells. The discovery will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy.

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New nano drug candidate kills aggressive breast cancer cells

Researchers have developed a new drug candidate that kills triple negative breast cancer cells. The discovery will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy.

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New nano drug candidate kills aggressive breast cancer cells

Researchers have developed a new drug candidate that kills triple negative breast cancer cells. The discovery will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy.

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Widening cancer gene testing is cost effective and could prevent millions of cancer cases

Screening entire populations for breast and ovarian cancer gene mutations could prevent millions more breast and ovarian cancer cases across the world compared to current clinical practice, according to an international study. The research also shows that it is cost effective in high and upper-middle income countries.

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Widening cancer gene testing is cost effective and could prevent millions of cancer cases

Screening entire populations for breast and ovarian cancer gene mutations could prevent millions more breast and ovarian cancer cases across the world compared to current clinical practice, according to an international study. The research also shows that it is cost effective in high and upper-middle income countries.

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Widening cancer gene testing is cost effective and could prevent millions of cancer cases

Screening entire populations for breast and ovarian cancer gene mutations could prevent millions more breast and ovarian cancer cases across the world compared to current clinical practice, according to an international study. The research also shows that it is cost effective in high and upper-middle income countries.

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Potential treatment for rare degenerative disease

A pharmacology professor and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment.

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Potential treatment for rare degenerative disease

A pharmacology professor and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment.

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Credit-card sized tool provides new insights into how cancer cells invade host tissues

Researchers have developed a credit-card sized tool for growing cancer cells outside the human body, which they believe will enhance their understanding of breast cancer metastasis. The device reproduces various environments within the human body where breast cancer cells live. Studying the cells as they go through the process of invasion and metastasis could point the way toward new biomarkers and drugs to diagnose and treat cancer.

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Response to stimulation in IVF may predict longer term health risks

A follow-up study of almost 20,000 young women who had a first cycle of IVF in Denmark between 1995 and 2014 indicates that those who responded poorly to treatment, with few eggs collected, are at a significantly increased risk of later age-related diseases.

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Response to stimulation in IVF may predict longer term health risks

A follow-up study of almost 20,000 young women who had a first cycle of IVF in Denmark between 1995 and 2014 indicates that those who responded poorly to treatment, with few eggs collected, are at a significantly increased risk of later age-related diseases.

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New link between calcium and cardiolipin in heart defects

To function properly, the heart needs energy from cells' powerhouses, the mitochondria. In turn, mitochondria boost their energy output when calcium levels rise around them, a signal that more energy is needed. A new study shows that a shortage of cardiolipin, a type of fat, in the mitochondrial membrane, prevents calcium from entering mitochondria. The result helps explain heart and muscle weakness in the rare genetic disorder Barth syndrome.

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New link between calcium and cardiolipin in heart defects

To function properly, the heart needs energy from cells' powerhouses, the mitochondria. In turn, mitochondria boost their energy output when calcium levels rise around them, a signal that more energy is needed. A new study shows that a shortage of cardiolipin, a type of fat, in the mitochondrial membrane, prevents calcium from entering mitochondria. The result helps explain heart and muscle weakness in the rare genetic disorder Barth syndrome.

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One in five Georgian Londoners had syphilis by their mid-30s

250 years ago, over one-fifth of Londoners had contracted syphilis by their 35th birthday, historians have calculated.

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Coronary calcium scoring: Personalized preventive care for those most at risk

An imaging test called coronary calcium scoring can help doctors to make the right recommendation about the use of statin therapy. The test is a 10-minute CT (computed tomography) scan looking for calcium deposits in the arteries supplying blood to the heart. Calcium deposits indicate the presence of coronary plaque, also known as atherosclerosis.

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Coronary calcium scoring: Personalized preventive care for those most at risk

An imaging test called coronary calcium scoring can help doctors to make the right recommendation about the use of statin therapy. The test is a 10-minute CT (computed tomography) scan looking for calcium deposits in the arteries supplying blood to the heart. Calcium deposits indicate the presence of coronary plaque, also known as atherosclerosis.

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'Biologically relevant' levels of a fertility hormone are detected in human hair samples

The prospect of a non-invasive test of ovarian reserve is a little closer following results from a study showing that measurement of a fertility hormone can be accurately taken from a sample of human hair.

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'Biologically relevant' levels of a fertility hormone are detected in human hair samples

The prospect of a non-invasive test of ovarian reserve is a little closer following results from a study showing that measurement of a fertility hormone can be accurately taken from a sample of human hair.

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Hot flushes and night sweats linked to 70% increase in cardiovascular disease

New research has found that women who have hot flushes and night sweats after menopause are 70 per cent more likely to have heart attacks, angina and strokes.

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Hot flushes and night sweats linked to 70% increase in cardiovascular disease

New research has found that women who have hot flushes and night sweats after menopause are 70 per cent more likely to have heart attacks, angina and strokes.

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Glowing dye may aid in eliminating cancer

When a solid cancer is surgically removed, any small piece that is left behind increases the chance of a local recurrence or spread. In a pilot study of dogs with mammary tumors, a disease very similar to human breast cancer, a team found that an injectable dye, which glows under near-infrared light, illuminated cancerous growth in the primary tumor as well as in lymph nodes.

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Discovery of key protein behind cancer relapse and progression can lead to new therapies

Reports show that cancer is the second-highest leading cause of death globally. A recent study by scientists provides new evidence supporting the presence of a key mechanism behind progression and relapse in cancer. The study discusses the role of MBNL1 protein as a biomarker for cancer prognosis, which can lead to the development of new treatment strategies for cancer.

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COVID-19 affects adolescent and young adults sexual and reproductive health

Social distancing and limited access to contraceptive and abortion care during the COVID-19 pandemic is affecting the sexual and reproductive health of adolescents and young adults according to a new study.

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Two new, powerful small molecules may be able to kill cancers that other therapies can't

Scientists have identified and developed two potent small molecules that appear to suppress tumor growth in multiple cancers even when other treatments cease to work, possibly due to the development of drug resistance. Called CS1 and CS2, these cancer inhibitor compounds are part of a protein known as ''fat mass and obesity-associated protein.'' This FTO protein plays a critical role in cancer development and progression, primarily because it regulates cancer stem cells and immune evasion.

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3D X-ray reveals secrets from inside bones

Researchers have uncovered a previously unknown substructure in bone tissue using a new X-ray technique to produce 3D images of the internal structure of bones. The discovery potentially questions fundamentally a number of the models of bone tissue and the mechanical properties of bones that, among other things, is used to describe the process of bone formation.

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3D X-ray reveals secrets from inside bones

Researchers have uncovered a previously unknown substructure in bone tissue using a new X-ray technique to produce 3D images of the internal structure of bones. The discovery potentially questions fundamentally a number of the models of bone tissue and the mechanical properties of bones that, among other things, is used to describe the process of bone formation.

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A good vitamin D status can protect against cancer

A good vitamin D status is beneficial both in cancer prevention and in the prognosis of several cancers, according to a new research review. The anti-cancer effects of vitamin D are especially pronounced in the prevention and treatment of colon cancer and blood cancers. In addition, high vitamin D responsiveness can be linked to a smaller cancer risk. Vitamin D responsiveness varies between individuals, affecting their need for vitamin D supplementation.

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Different hormone therapies affect brain function differently

Sex hormones influence the structure and function of the brain, but little is known about the effect of hormone therapies (HT) on changes in the brain during menopause. A new study shows smaller increases in structural brain changes related to aging were associated with hormone-level changes from transdermal estradiol or oral conjugated equine estrogen.

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Different hormone therapies affect brain function differently

Sex hormones influence the structure and function of the brain, but little is known about the effect of hormone therapies (HT) on changes in the brain during menopause. A new study shows smaller increases in structural brain changes related to aging were associated with hormone-level changes from transdermal estradiol or oral conjugated equine estrogen.

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Physical activity in all of its forms may help maintain muscle mass in midlife

Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. Physical activity in all of its forms may help maintain muscle mass in midlife.

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Physical activity in all of its forms may help maintain muscle mass in midlife

Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. Physical activity in all of its forms may help maintain muscle mass in midlife.

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'Terminator' protein halts cancer-causing cellular processes

New research finds that a protein called TiPARP acts as a terminator for several cancer-causing transcription factors, including HIF-1, which is implicated in many cancers, including breast cancer. The research demonstrates that TiPARP, therefore, is a tumor suppressor.

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Wording of vaccination messages influences behavior

An experiment has revealed that relatively small differences in messages influenced people's attitudes about the human papillomavirus or HPV vaccine, which has been shown to help prevent cancer.

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Genetic cause of difference in sexual development uncovered

Researchers have identified a cause of testicular tissue developing in people with female chromosomes.

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Probiotics with top-performing Lactobacillus strains may improve vaginal health

Vaginal Lactobacillus bacterial strains largely perform better than strains currently used in probiotics for vaginal health, according to a new study. The findings suggest that a vaginal health probiotic that includes top-performing vaginal Lactobacillus strains may improve treatment options for bacterial vaginosis.

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Disrupted sleep increases the risk of cardiovascular disease by promoting inflammation

Sleep disruption has been shown to be associated with an increased risk of atherosclerosis, but the mechanism has been unclear. A new study reveals that fragmented sleep exacerbates atherosclerosis and may raise the risk of stroke via an effect on inflammatory pathways.

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Disrupted sleep increases the risk of cardiovascular disease by promoting inflammation

Sleep disruption has been shown to be associated with an increased risk of atherosclerosis, but the mechanism has been unclear. A new study reveals that fragmented sleep exacerbates atherosclerosis and may raise the risk of stroke via an effect on inflammatory pathways.

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PFAS exposure may cause early menopause in women

Per- and polyfluoroalkyl substance (PFAS) exposure may cause menopause to occur two years earlier in women, according to a new study.

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PFAS exposure may cause early menopause in women

Per- and polyfluoroalkyl substance (PFAS) exposure may cause menopause to occur two years earlier in women, according to a new study.

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Association between outdoor light at night and breast cancer risk among postmenopausal women

Outdoor light at night was linked to a higher risk of breast cancer in a recent study.

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Association between outdoor light at night and breast cancer risk among postmenopausal women

Outdoor light at night was linked to a higher risk of breast cancer in a recent study.

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Association between outdoor light at night and breast cancer risk among postmenopausal women

Outdoor light at night was linked to a higher risk of breast cancer in a recent study.

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A satisfying romantic relationship may improve breast cancer survivors' health

Breast cancer survivors in romantic relationships who feel happy and satisfied with their partners may be at lower risk for a host of health problems, new research suggests.

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Vitamin D determines severity in COVID-19 so government advice needs to change, experts urge

Researchers are urging the Irish government to immediately change recommendations on vitamin D supplements given recent changes by Welsh, English and Scottish governments.

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Killing 'sleeper cells' may enhance breast cancer therapy

The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer, according to preclinical studies. The promising preclinical results for this 'triple therapy' have underpinned a phase 1 clinical trial in Melbourne, Australia, that is combining venetoclax with hormone therapy and CDK4/6 inhibitors in patients with ER+ breast cancer.

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Killing 'sleeper cells' may enhance breast cancer therapy

The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer, according to preclinical studies. The promising preclinical results for this 'triple therapy' have underpinned a phase 1 clinical trial in Melbourne, Australia, that is combining venetoclax with hormone therapy and CDK4/6 inhibitors in patients with ER+ breast cancer.

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Killing 'sleeper cells' may enhance breast cancer therapy

The anti-cancer medicine venetoclax could improve the current therapy for estrogen receptor-positive (ER+) breast cancer, according to preclinical studies. The promising preclinical results for this 'triple therapy' have underpinned a phase 1 clinical trial in Melbourne, Australia, that is combining venetoclax with hormone therapy and CDK4/6 inhibitors in patients with ER+ breast cancer.

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Trial questions benefits of organic nitrates for bone health

A new study found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.

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Trial questions benefits of organic nitrates for bone health

A new study found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.

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Arteries respond in opposite ways for males and females

A protein known to expand blood vessels -- key to controlling conditions like high blood pressure -- actually has different functions in males and females, new UC Davis Health research shows. Conducted using arterial cells from mice, the study is the first to identify sex-based distinctions in how the protein -- Kv2.1 -- works.

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Arteries respond in opposite ways for males and females

A protein known to expand blood vessels -- key to controlling conditions like high blood pressure -- actually has different functions in males and females, new UC Davis Health research shows. Conducted using arterial cells from mice, the study is the first to identify sex-based distinctions in how the protein -- Kv2.1 -- works.

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First study of multicancer blood test to screen for cancer guide intervention

Results from a first-of-its-kind study of a multicancer blood test in more than 9,900 women with no evidence or history of cancer showed the liquid biopsy test safely detected 26 undiagnosed cancers, enabling potentially curative treatment.

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First study of multicancer blood test to screen for cancer guide intervention

Results from a first-of-its-kind study of a multicancer blood test in more than 9,900 women with no evidence or history of cancer showed the liquid biopsy test safely detected 26 undiagnosed cancers, enabling potentially curative treatment.

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New type of immune cell discovered in breast ducts

Breast cancer researchers have discovered a new type of immune cell that helps to keep breast tissue healthy by regulating a vital process within mammary ducts - the sites where milk is produced and transported, but also where most breast cancers arise.

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Scientists unveil how general anesthesia works

The discovery of general anesthetics -- compounds which induce unconsciousness, prevent control of movement and block pain -- helped transform dangerous operations into safe surgery. But scientists still don't understand exactly how general anesthetics work. Now, researchers have revealed how a general anesthetic called isoflurane weakens the transmission of electrical signals between neurons, at junctions called synapses.

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Scientists unveil how general anesthesia works

The discovery of general anesthetics -- compounds which induce unconsciousness, prevent control of movement and block pain -- helped transform dangerous operations into safe surgery. But scientists still don't understand exactly how general anesthetics work. Now, researchers have revealed how a general anesthetic called isoflurane weakens the transmission of electrical signals between neurons, at junctions called synapses.

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New targeted agent produces considerable responses in patients with uterine cancer

The DNA repair-blocking drug adavosertib shrinks tumors in nearly one-third of patients in clinical trial data to be shared at the Society for Gynecologic Oncology (SGO) Annual Meeting on Women's Cancer.

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New targeted agent produces considerable responses in patients with uterine cancer

The DNA repair-blocking drug adavosertib shrinks tumors in nearly one-third of patients in clinical trial data to be shared at the Society for Gynecologic Oncology (SGO) Annual Meeting on Women's Cancer.

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Human uterus colonized by clones with cancer-driving mutations that arise early in life

Many cells in the inner lining of the uterus carry 'cancer-driving' mutations that frequently arise early in life, report scientists. The research team conducted whole-genome sequencing of healthy human endometrium, providing a comprehensive overview of the rates and patterns of DNA changes in this tissue.

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Human uterus colonized by clones with cancer-driving mutations that arise early in life

Many cells in the inner lining of the uterus carry 'cancer-driving' mutations that frequently arise early in life, report scientists. The research team conducted whole-genome sequencing of healthy human endometrium, providing a comprehensive overview of the rates and patterns of DNA changes in this tissue.

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Researchers achieve remote control of hormone release

Using magnetic nanoparticles, scientists stimulate the adrenal gland in rodents to control release of hormones linked to stress.

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Researchers achieve remote control of hormone release

Using magnetic nanoparticles, scientists stimulate the adrenal gland in rodents to control release of hormones linked to stress.

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Treatment for spasticity in mice, following spinal cord injuries discovered

In experiments with mice, researchers have studied neuronal mechanisms and found a way to by and large prevent spasticity from developing after spinal cord injuries. A new study shows that the researchers have done this by using already approved medicine for high blood pressure.

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Treatment for spasticity in mice, following spinal cord injuries discovered

In experiments with mice, researchers have studied neuronal mechanisms and found a way to by and large prevent spasticity from developing after spinal cord injuries. A new study shows that the researchers have done this by using already approved medicine for high blood pressure.

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Experimental drug offers hope for preventing cancer relapse

A drug that is well-tolerated in patients and prevents cancer coming back in mice has been identified.

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Traditional vegetable diet lowers the risk of premature babies

It turns out we should follow our parent' advice when we're thinking about becoming parents ourselves, with a study finding eating the traditional 'three-veggies' before pregnancy lowers the risk of a premature birth.

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Traditional vegetable diet lowers the risk of premature babies

It turns out we should follow our parent' advice when we're thinking about becoming parents ourselves, with a study finding eating the traditional 'three-veggies' before pregnancy lowers the risk of a premature birth.

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Researchers describe possible mechanism for link between obesity and breast cancer

It is widely accepted that higher levels of body fat increase the risk of developing breast cancer, as well as other cancers. A new article proposes a unique theory that a protein secreted by fat cells drives the development of breast cancer.

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Researchers describe possible mechanism for link between obesity and breast cancer

It is widely accepted that higher levels of body fat increase the risk of developing breast cancer, as well as other cancers. A new article proposes a unique theory that a protein secreted by fat cells drives the development of breast cancer.

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Researchers describe possible mechanism for link between obesity and breast cancer

It is widely accepted that higher levels of body fat increase the risk of developing breast cancer, as well as other cancers. A new article proposes a unique theory that a protein secreted by fat cells drives the development of breast cancer.

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Cancer scientists aim to use protein power to stop tumor growth

Scientists have created a new therapy option that may help halt tumor growth in certain cancers such as prostate, which is among the most common types of cancer in men.

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Cancer scientists aim to use protein power to stop tumor growth

Scientists have created a new therapy option that may help halt tumor growth in certain cancers such as prostate, which is among the most common types of cancer in men.

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Cancer scientists aim to use protein power to stop tumor growth

Scientists have created a new therapy option that may help halt tumor growth in certain cancers such as prostate, which is among the most common types of cancer in men.

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Doubts cast over accuracy of many popular fertility and pregnancy planning apps

Many popular fertility and pregnancy planning apps may be inaccurate, suggest the results of a scoping review of the available evidence.

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Fiber consumption linked to lower breast cancer risk

Consuming a diet high in fiber was linked with a reduced incidence of breast cancer in an analysis of all relevant prospective studies.

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Fiber consumption linked to lower breast cancer risk

Consuming a diet high in fiber was linked with a reduced incidence of breast cancer in an analysis of all relevant prospective studies.

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Fiber consumption linked to lower breast cancer risk

Consuming a diet high in fiber was linked with a reduced incidence of breast cancer in an analysis of all relevant prospective studies.

from Breast Cancer News -- ScienceDaily https://ift.tt/2UMQaVS

Rapid infectious disease shifts in Chinese children and adolescents prior to COVID-19

Deaths of children and adolescents in China due to infectious diseases were becoming rare prior to the covid-19 pandemic, according to a new study.

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Experiences of undesired effects of hormonal contraception

A study of women who experienced mental ill-health from a hormonal contraception indicates they value their mental well-being higher than a satisfactory sex life. Their experiences can influence their choice of contraception. This is one of four themes that researchers have identified in interviews with 24 women who experience negative effects of some hormonal contraception.

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Consuming extra calories can help exercising women avoid menstrual disorders

Exercising women who struggle to consume enough calories and have menstrual disorders can simply increase their food intake to recover their menstrual cycle, according to a new study.

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Consuming extra calories can help exercising women avoid menstrual disorders

Exercising women who struggle to consume enough calories and have menstrual disorders can simply increase their food intake to recover their menstrual cycle, according to a new study.

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Microbiome may hold key to identifying HPV-infected women at risk for pre-cancer

Gardnerella bacteria in the cervicovaginal microbiome may serve as a biomarker to identify women infected with human papillomavirus (HPV) who are at risk for progression to precancer, according to a new study.

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Microbiome may hold key to identifying HPV-infected women at risk for pre-cancer

Gardnerella bacteria in the cervicovaginal microbiome may serve as a biomarker to identify women infected with human papillomavirus (HPV) who are at risk for progression to precancer, according to a new study.

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Experiments in mice and human cells shed light on best way to deliver nanoparticle therapy for cancer

Researchers in the cancer nanomedicine community debate whether use of tiny structures, called nanoparticles, can best deliver drug therapy to tumors passively -- allowing the nanoparticles to diffuse into tumors and become held in place, or actively -- adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice suggests the question is even more complicated.

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High-speed microscope captures fleeting brain signals

Neuroscientists can now capture millisecond electrical changes in neurons in the cortex of an alert mouse, allowing tracing of neural signals, including subthreshold events, in the brain. The new technique combines all-optical scanning with two-photon fluorescence imaging to produce a 2D rasterized picture every 1,000-3,000 milliseconds. That and another technique that allows 3D imaging of large areas of the mouse cortex to a depth of 650 microns will aid study of neural circuits.

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High-speed microscope captures fleeting brain signals

Neuroscientists can now capture millisecond electrical changes in neurons in the cortex of an alert mouse, allowing tracing of neural signals, including subthreshold events, in the brain. The new technique combines all-optical scanning with two-photon fluorescence imaging to produce a 2D rasterized picture every 1,000-3,000 milliseconds. That and another technique that allows 3D imaging of large areas of the mouse cortex to a depth of 650 microns will aid study of neural circuits.

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Ball-and-chain inactivation of ion channels visualized by cryo-electron microscopy

Ion channels, which allow potassium and sodium ions to flow in and out of cells, are crucial in neuronal 'firing' in the central nervous system and for brain and heart function. These channels use a ''ball-and-chain'' mechanism to help regulate their ion flow, according to a new study.

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Ball-and-chain inactivation of ion channels visualized by cryo-electron microscopy

Ion channels, which allow potassium and sodium ions to flow in and out of cells, are crucial in neuronal 'firing' in the central nervous system and for brain and heart function. These channels use a ''ball-and-chain'' mechanism to help regulate their ion flow, according to a new study.

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Tomosynthesis outperforms digital mammography in five-year study

A new study has found that the advantages of digital breast tomosynthesis (DBT) over digital mammography (DM), including increased cancer detection and fewer false positive findings, are maintained over multiple years and rounds of screening. In addition, research showed that DBT screening helped detect a higher proportion of poor prognosis cancers than DM.

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Tomosynthesis outperforms digital mammography in five-year study

A new study has found that the advantages of digital breast tomosynthesis (DBT) over digital mammography (DM), including increased cancer detection and fewer false positive findings, are maintained over multiple years and rounds of screening. In addition, research showed that DBT screening helped detect a higher proportion of poor prognosis cancers than DM.

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Tomosynthesis outperforms digital mammography in five-year study

A new study has found that the advantages of digital breast tomosynthesis (DBT) over digital mammography (DM), including increased cancer detection and fewer false positive findings, are maintained over multiple years and rounds of screening. In addition, research showed that DBT screening helped detect a higher proportion of poor prognosis cancers than DM.

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Researchers help restore hormonal balance disrupted in metabolic diseases

Many health problems in the developed world stem from the disruption of a delicate metabolic balance between glucose production and energy utilization in the liver. Now scientists report that they have discovered the molecular mechanisms that trigger metabolic imbalance between these two distinct but linked processes, a finding with implications for the treatment of diabetes and non-alcoholic fatty liver disease.

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Researchers help restore hormonal balance disrupted in metabolic diseases

Many health problems in the developed world stem from the disruption of a delicate metabolic balance between glucose production and energy utilization in the liver. Now scientists report that they have discovered the molecular mechanisms that trigger metabolic imbalance between these two distinct but linked processes, a finding with implications for the treatment of diabetes and non-alcoholic fatty liver disease.

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Starve a tumor, feed a cell: How cancers can resist drugs

With drug resistance a major challenge in the fight against cancer, a discovery by biologists could offer new approaches to overcoming the obstacle. Their research reveals that a mechanism enabling the diseased cells to scavenge dead cell debris for nourishment holds a pivotal role.

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Curcumin is the spice of life when delivered via tiny nanoparticles

For years, curry lovers have sworn by the anti-inflammatory properties of turmeric, but its active compound, curcumin, has long frustrated scientists hoping to validate these claims with clinical studies.

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Egg stem cells do not exist, new study shows

Researchers have analyzed all cell types in the human ovary and found that the hotly debated so-called egg stem cells do not exist.

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Egg stem cells do not exist, new study shows

Researchers have analyzed all cell types in the human ovary and found that the hotly debated so-called egg stem cells do not exist.

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Discovery of bacterial ancestor yields new insight on calcium channels

The discovery of a calcium channel that is likely a 'missing link' in the evolution of mammalian calcium channels has been reported today.

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New study associates intake of dairy milk with greater risk of breast cancer

Intake of dairy milk is associated with a greater risk of breast cancer in women -- up to 80% depending on the amount consumed -- according to a new study.

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Discovery of bacterial ancestor yields new insight on calcium channels

The discovery of a calcium channel that is likely a 'missing link' in the evolution of mammalian calcium channels has been reported today.

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New study associates intake of dairy milk with greater risk of breast cancer

Intake of dairy milk is associated with a greater risk of breast cancer in women -- up to 80% depending on the amount consumed -- according to a new study.

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New study associates intake of dairy milk with greater risk of breast cancer

Intake of dairy milk is associated with a greater risk of breast cancer in women -- up to 80% depending on the amount consumed -- according to a new study.

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New tech takes radiation out of cancer screening

Researchers have developed a new, inexpensive technology that could save lives and money by routinely screening women for breast cancer without exposure to radiation. The system uses harmless microwaves and artificial intelligence (AI) software to detect even small, early-stage tumors within minutes.

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CRISPR gene cuts may offer new way to chart human genome

In search of new ways to sequence human genomes and read critical alterations in DNA, researchers say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumor genes, which can be used to collect sequence information.

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An apple a day might help keep bothersome menopause symptoms away

A healthy diet rich in fruits and vegetables is known to benefit the human body in so many ways. Now a new study suggests that it may also play a role in lessening various menopause symptoms.

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An apple a day might help keep bothersome menopause symptoms away

A healthy diet rich in fruits and vegetables is known to benefit the human body in so many ways. Now a new study suggests that it may also play a role in lessening various menopause symptoms.

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Drug cocktail holds promise for spinal injuries

Scientists have discovered a combination of two commonly available drugs that could help the body heal spinal fractures.

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Drug cocktail holds promise for spinal injuries

Scientists have discovered a combination of two commonly available drugs that could help the body heal spinal fractures.

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How too much fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel -- a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises.

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How too much fluoride causes defects in tooth enamel

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel -- a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises.

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Replacing animal testing with synthetic cell scaffolds

Electrospun synthetic cell scaffolds are not only more consistent than animal cells for cancer research, they hold the potential to replace animal testing.

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Global study maps cancer mutations in large catalogue

Mutations in 38 different types of cancer have been mapped by means of whole genome analysis by an international team of researchers. A catalogue of the cancer mutations will be available worldwide to doctors and researchers.

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A new substance prevents vascular calcification

The calcification of blood vessels and other soft tissues is problematic. Researchers have discovered a substance that prevents vascular calcification.

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New therapy option identified for early-stage breast cancer

Radionuclide therapy has been successful in delaying the growth of disseminated tumor cells in early-stage breast cancer. Radium-233 dichloride not only impacts cells directly hit by radiation but also has significant effects on cells outside of the radiation field, according to new research.

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Give and take: Cancer chromosomes give the game away

As tumors develop, cancer cells gain and lose so-called 'chromosome arms', changing their response to drugs, a finding which may offer better personalized treatments for 17 types of cancer.

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The first roadmap for ovarian aging

Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear. Now, scientists have discovered, in unprecedented detail, how ovaries age in non-human primates. The findings reveal several genes that could be used as biomarkers and point to therapeutic targets for diagnosing and treating female infertility and age-associated ovarian diseases, such as ovarian cancer, in humans.

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PET/MRI identifies notable breast cancer imaging biomarkers

Researchers have identified several potentially useful breast cancer biomarkers that indicate the presence and risk of malignancy, according to new research.

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Breastfeeding and childbearing linked to lower early menopause risk

Results of a new epidemiological analysis of more than 108,000 women observed a lower risk of early menopause among women who had at least one pregnancy lasting at least six months and among those who had breastfed their infants. Further, risk was lowest among those who breastfed exclusively.

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Why eating yogurt may help lessen the risk of breast cancer

One of the causes of breast cancer may be inflammation triggered by harmful bacteria suggest researchers. Scientists advise consuming natural yogurt, which contains beneficial bacteria which dampens inflammation and which is similar to the bacteria found in breastfeeding mothers. Their suggestion is that this bacteria is protective because breast feeding reduces the risk of breast cancer. The consumption of yogurt is also associated with a reduction in the risk of breast cancer.

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Editing RNA delivers precision strike on triple-negative breast cancer

An abundance of microRNA-21 predicts lower survival in people with hard-to-treat 'triple-negative' breast cancer. An innovative compound targets the oncogenic sequence and removes it, killing the cancer cells and stopping their spread in a mouse model, while leaving healthy cells untouched.

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Blood tests can predict timing of final menstrual period

Blood tests could replace menstrual periods as a gauge for when a women is nearing menopause, according to new research.

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Two-drug combo halts the growth of cancer cells

Researchers have discovered a two-drug combo that halts the growth of cancer cells that carry HER2 mutations.

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Missing link in mechanisms underlying fight-or-flight response

We've all felt the effects of an adrenaline rush. Faced with danger, real or perceived, the heart beats faster, breathing quickens and muscles tighten as the body prepares to fight a threat or flee from it.

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Refining breast cancer classification by multiplexed imaging

An imaging approach enables the study of breast cancer tissue in greater detail. It uses 35 biomarkers to identify the different cell types in breast tumors and its surrounding area compared to the current standard of testing single markers. This increases the precision of tumor analysis and classification - and improves personalized diagnostics for breast cancer patients.

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Hot flashes impair memory performance

If you're having difficulty identifying the right word to express yourself clearly or remembering a story correctly, you may blame menopause. A new study suggests that physiologic hot flashes are associated with decreased verbal memory and with alterations in brain function during encoding and retrieval of memory, especially in the hippocampus and prefrontal cortex.

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Researchers discover novel potential target for drug addiction treatment

New research discovers a novel potential target for treating drug addiction through 'the hidden stars of the brain.'

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Activation of a distinct genetic pathway can slow the progress of metastatic breast cancer

Activation of the BMP4 signalling pathway presents a new therapeutic strategy to combat metastatic breast cancer, a disease that has shown no reduction in patient mortality over the past 20 years.

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Acid reflux drugs may have negative side effects for breast cancer survivors

Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors' memory and concentration.

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Hormone resistance in breast cancer linked to DNA 'rewiring'

Researchers have revealed changes to the 3D arrangement of DNA linked to treatment resistance in ER+ breast cancer.

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Pulling the plug on calcium pumps -- potential new treatment strategy for pancreatic cancer

UK scientists have identified a new way to kill pancreatic cancer cells by 'pulling the plug' on the energy generator that fuels calcium pumps on their cell surface. The study reports how switching off the cancer's energy supply causes the pancreatic cancer cells to become 'poisoned' by an irreversible build-up of calcium.

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Study shows lactate may prompt cancer formation

A byproduct of glucose called lactate, used by every cell in the body, may also prompt a mutated cell to become cancerous, according to new research.

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DNA Damage to Breast Cells from chemicals in some cosmetics, sunscreens

A new approach to studying the effects of two common chemicals used in cosmetics and sunscreens found they can cause DNA damage in breast cells at surprisingly low concentrations, while the same dose did not harm cells without estrogen receptors.

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Having less sex linked to earlier menopause

Women who engage in sexual activity weekly or monthly have a lower risk of entering menopause early relative to those who report having some form of sex less than monthly, according to a new study.

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Genetic study provides most comprehensive map of risk to date of breast cancer risk

A major international study of the genetics of breast cancer has identified more than 350 DNA 'errors' that increase an individual's risk of developing the disease. The scientists involved say these errors may influence as many as 190 genes.

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Step toward 'ink' development for 3-D printing a bioprosthetic ovary

For the first time, scientists identified and mapped the location of structural proteins in a pig ovary. Ongoing development of an 'ink' with these proteins will be used for 3-D printing an artificial (or bio-prosthetic) ovary that could be implanted and allow a woman to have a child.

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Starting point for designing drugs that cure clostridium difficile

A new article details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure C. diff -- a virulent health care-associated infection that causes severe diarrhea, nausea, internal bleeding, and potentially death.

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