New method identifies aggressive breast cancer

Aggressive forms of breast cancer often manipulate the immune response in their favor. This manipulation is revealed in humans by the same immunological 'signature' as in mice. This is shown by a new study. The method makes it possible to obtain an indication of the prognosis of the disease using patients' tumor tissue.

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Living through Katrina associated with higher death rate among breast cancer patients

Breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those patients not exposed to the storm, according to a researcher.

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Study identifies role of specific gene in hardening of blood vessel walls

New study implicates a specific gene -- HDAC9 -- in the calcification of the human aorta, the largest blood vessel in the body.

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Attacking metastatic breast cancer with sound

Drugs can be safely delivered to cancerous lymph nodes via the lymphatic system and then released inside the nodes using sound waves. Researchers tested the treatment on mice with metastatic breast cancer.

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Zeroing in on how a tumor suppressor protein is cast away

Researchers have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.

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Monitoring the corrosion of bioresorbable magnesium

Researchers have recently been able to monitor the corrosion of bioresorbable magnesium alloys at the nanoscale over a time scale of a few seconds to many hours. This is an important step towards accurately predicting how fast implants are resorbed by the body to enable the development of tailored materials for temporary implant applications.

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Simple test predicts dangerous pregnancy disorder

Researchers have developed a simple, low-cost way to predict preeclampsia, a potentially deadly condition that kills 76,000 mothers and 500,000 babies every year.

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Aggressive form of breast cancer influenced by dual action of genes and RNA

Women with an aggressive, less-common type of breast cancer, known as triple-negative, versus a more common form of the disease, could be differentiated from each other by a panel of 17 small RNA molecules that are directly influenced by genetic alterations typically found in cancer cells.

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Men with breast cancer face high mortality rates

Men with breast cancer are more likely to die than their female counterparts, across all stages of disease, with the disparity persisting even when clinical characteristics, such as cancer types, treatment and access to care are considered, according to a new study.

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HPV immunization program cuts pre-cancer rates by more than half

A school-based human papillomavirus (HPV) immunization program in British Columbia, Canada, is dramatically reducing rates of cervical pre-cancer in B.C. women, according to a new study.

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Adults with undiagnosed Celiac disease have lower bone density

New research has found lower bone density in adults who are likely to have undiagnosed celiac disease, an autoimmune disease triggered by consuming gluten, despite this group consuming more calcium and phosphorous than the control group.

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Digital breast tomosynthesis increases cancer detection over full-field mammography

A new article compares cancer detection rates (CDR) for screening digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM). Researchers found that DBT results in 'significantly increased CDR' -- irrespective of tumor type, size, or grade of cancer.

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Exercise guidelines for cancer survivors

For the rising number of cancer survivors worldwide, there's growing evidence that exercise is an important part of recovery. But how much, and what type of exercise, is needed?

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Oxygen in hyperbaric chamber provides relief after radiotherapy

Hyperbaric oxygen therapy (HBOT) can relieve self-reported symptoms and side-effects of radiotherapy against cancer in the pelvic region, a study shows. After 30-40 sessions in a hyperbaric chamber, many patients experienced reductions in bleeding, urinary incontinence, and pain alike.

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Climate change concerns have largely ignored role of access to effective contraception

Climate change concerns have largely ignored the importance of universal access to effective contraception, despite the impact of population growth on greenhouse gas emissions, argue experts.

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Hormone therapy associated with improved cognition

Estrogen has a significant role in overall brain health and cognitive function. That's why so many studies focused on the prevention of cognitive decline consider the effect of reduced estrogen levels during the menopause transition. A new study suggests a cognitive benefit from a longer reproductive window complemented with hormone therapy.

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Acceptance and commitment therapy may ease fear of recurrence in cancer survivors

Researchers report that Acceptance and Commitment Therapy (ACT) shows significant promise for treating fear of cancer recurrence in women who have survived breast cancer. Fear that cancer may come back or progress is especially common in breast cancer survivors, with up to 70% reporting that the fear affects their daily life.

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Scientists help immune system find hidden cancer cells

Cancer cells are masters at avoiding detection, but a new system can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss.

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New method visualizes groups of neurons as they compute

Using a fluorescent probe that lights up when brain cells are electrically active, researchers found they can image the activity of many neurons at once, in mice brains. The technique could allow neuroscientists to analyze circuits within the brain and link them to specific behaviors.

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'Wild idea' opens possible new frontier for preventing ovarian cancer

A laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.

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Chlamydia in testicular tissue linked to male infertility

The potential impact of undiagnosed sexually transmitted chlamydia infection on men's fertility has been highlighted in a study, which for the first time found chlamydia in the testicular tissue biopsies of infertile men whose infertility had no identified cause.

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Insights on treatment and prognosis of male breast cancer

A recent analysis reveals that treatment of male breast cancer has evolved over the years. In addition, certain patient-, tumor-, and treatment-related factors are linked with better survival.

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Research maps key signaling pathways linking calcium entry and exit in activated T cells

Like entrance and exit doors on a building, a cell's outer surface has doors -- channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells possess unique sets of 'doors', including ones that specialize in calcium ion movement. Now, researchers describe a unique mechanism for coordinating these calcium entrance and exit 'doors' on T cells that helps them carry out their jobs and ensure normal immune function.

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How can ultrasonic brain stimulation cure brain diseases?

Scientists found a calcium channel expressed in astrocytes in the brain to be a highly sensitive target for LILFU-induced neuronal activity in the motor cortex, such as tail movement.

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Mapping normal breast development to better understand cancer

Breast cancer is one of the most prevalent cancers, and some forms rank among the most difficult to treat. Its various types and involvement of many different cells makes targeting such tumors difficult. Now, researchers have used a state-of-the-art technology to profile each cell during normal breast development in order to understand what goes wrong in cancer.

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Voltage gated calcium channels 'read' electric patterns in embryos to create cartilage and bone

Scientists have revealed how the electrical patterns formed within an embryo initiate a cascade of molecular changes that culminate in the development of cartilage and bone. Prior studies have shown these electrical patterns appear like blueprints of the tissues and organs that eventually take shape as the embryo matures. The new study demonstrates that voltage gated calcium channels 'read' the electrical pattern, setting off the expression of genes that guide differentiation to mature cells.

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Critical process for how breast cancer spreads in bones

Researchers have identified a pair of proteins believed to be critical for spreading, or metastasizing, breast cancer to bone.

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New evolution-busting drug overcomes resistance in aggressive breast cancers

A new type of drug that blocks one of cancer's key evolutionary escape routes from chemotherapy could be used to treat aggressive breast cancers, a new study has shown.

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Aggressive breast cancers store large amounts of energy, which enables it to spread

Researchers found that aggressive breast cancers store glycogen in very large amounts, offering an explanation of how cells can change their function to evade treatment, grow and spread. Targeting an enzyme involved in this process could potentially treat or prevent metastases.

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Early menopause predictor of heart disease

Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers.

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Scientists ID new targets to treat fibrosis, a feature of many chronic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term -- but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis -- which impacts several chronic diseases.

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Early menopause predictor of heart disease

Women who reach menopause before the age of 50 have an increased risk of cardiovascular disease, according to researchers.

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Laser therapy gains credibility as effective option for treating vaginal problems

Nearly 50% of menopausal women complain of vaginal dryness, itching, and burning, among other commonly reported menopause symptoms. Laser therapy is one of the newer techniques for addressing these problems. A new study suggests that it is as effective and safe as vaginal estrogen in improving sexual and urinary functionality.

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Decades-long drop in breast cancer death rate continues

A decades-long decline in the breast cancer death rate continues, but has begun to slow in recent years.

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Tenfold increase in number of adolescents on HIV treatment in South Africa since 2010, but many still untreated

A new study of more than 700,000 one to 19-year olds being treated for HIV infection suggests a ten-fold increase in the number of adolescents aged 15 to 19 receiving HIV treatment in South Africa.

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Immune therapy eliminates tumor cells in early triple negative breast cancer

Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to new results from the KEYNOTE-522 trial. Interim results from the study, which is the first phase III trial of immunotherapy in early breast cancer, also indicated an improvement in event-free survival.

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Breast cancer: New data on cohort with recurrence score 26-100 shows 93% cancer-free rate at 5 years

In the prospective TAILORx trial, 93% of women with hormone-sensitive, HER2-negative, axillary node-negative breast cancer and a high Recurrence Score 26-100 were estimated to be cancer-free at five years. This outcome was much better than expected with endocrine therapy alone. The finding adds to limited data on outcomes with a high RS of 26-100, treated with taxane and/or anthracycline-containing chemotherapy plus endocrine therapy. It adds to the body of evidence supporting use of the RS.

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