Menopausal hormone therapy and breast cancer incidence

New research suggest that all types of MHT, except topical vaginal estrogens, are associated with increased risks of breast cancer, and that the risks are greater for users of estrogen-progestagen hormone therapy than for estrogen-only hormone therapy. For estrogen-progestagen therapy, the risks were greater if the progestagen was included daily rather than intermittently (eg, for 10-14 days per month).

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Menopausal hormone therapy and breast cancer incidence

New research suggest that all types of MHT, except topical vaginal estrogens, are associated with increased risks of breast cancer, and that the risks are greater for users of estrogen-progestagen hormone therapy than for estrogen-only hormone therapy. For estrogen-progestagen therapy, the risks were greater if the progestagen was included daily rather than intermittently (eg, for 10-14 days per month).

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Menopausal hormone therapy and breast cancer incidence

New research suggest that all types of MHT, except topical vaginal estrogens, are associated with increased risks of breast cancer, and that the risks are greater for users of estrogen-progestagen hormone therapy than for estrogen-only hormone therapy. For estrogen-progestagen therapy, the risks were greater if the progestagen was included daily rather than intermittently (eg, for 10-14 days per month).

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Waist size, not body mass index, may be more predictive of coronary artery disease

For years, women have been told that weight gain could lead to heart disease. A new study indicates that it is the location of the fat that matters most, with abdominal fat representing the greatest harm and not overall body mass index (BMI) when assessing risk for coronary artery disease (CAD).

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Waist size, not body mass index, may be more predictive of coronary artery disease

For years, women have been told that weight gain could lead to heart disease. A new study indicates that it is the location of the fat that matters most, with abdominal fat representing the greatest harm and not overall body mass index (BMI) when assessing risk for coronary artery disease (CAD).

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Mechanism inducing self-killing of cancer cells

A research team has developed helical polypeptide potassium ionophores that lead to the onset of programmed cell death.

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Mechanism inducing self-killing of cancer cells

A research team has developed helical polypeptide potassium ionophores that lead to the onset of programmed cell death.

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Novel therapy studied for inherited breast cancer

Adding back a tiny molecule, microRNA 223-3p, to BRCA1-mutant cancer cells forces the cancer to die, researchers discovered. BRCA1-mutant cancer is the type of inherited cancer for which Angelina Jolie had preventive surgery in 2013.

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Greater left ventricular mass increases risk of heart failure

Elevated left ventricular mass, known as left-ventricular hypertrophy, is a stronger predictor of coronary artery disease-related death and heart failure than coronary artery calcium score, according to a new study.

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Greater left ventricular mass increases risk of heart failure

Elevated left ventricular mass, known as left-ventricular hypertrophy, is a stronger predictor of coronary artery disease-related death and heart failure than coronary artery calcium score, according to a new study.

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Scientists identify potential cause of statin-related muscle pain

An international team of researchers may have discovered why some people experience muscle pain after taking statins and have shown that moderate exercise may be a good way for people taking statins to avoid these symptoms.

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Scientists identify potential cause of statin-related muscle pain

An international team of researchers may have discovered why some people experience muscle pain after taking statins and have shown that moderate exercise may be a good way for people taking statins to avoid these symptoms.

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Oncologists echo findings that suggest a reduced risk of breast cancer recurrence

A modified drug combination may lead to a decreased chance of disease recurrence for women with high risk, HER-2 negative breast cancer.

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Oncologists echo findings that suggest a reduced risk of breast cancer recurrence

A modified drug combination may lead to a decreased chance of disease recurrence for women with high risk, HER-2 negative breast cancer.

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Mechanism accelerates polycystic kidney disease

Researchers uncover a previously unrecognized mechanism that may accelerate polycystic kidney disease.

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Oncologists echo findings that suggest a reduced risk of breast cancer recurrence

A modified drug combination may lead to a decreased chance of disease recurrence for women with high risk, HER-2 negative breast cancer.

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Mechanism accelerates polycystic kidney disease

Researchers uncover a previously unrecognized mechanism that may accelerate polycystic kidney disease.

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Depression, anxiety linked to opioid use and reduced survival in women with breast cancer

The findings should encourage doctors to better manage mental health in patients with breast cancer and spur care providers to consider alternative pain management such as physical therapy, massage and acupuncture, the researchers say.

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Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

Researchers show that heterogeneity of both breast cancer cells themselves and immune composition of the tumor microenvironment are important considerations for therapy.

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Depression, anxiety linked to opioid use and reduced survival in women with breast cancer

The findings should encourage doctors to better manage mental health in patients with breast cancer and spur care providers to consider alternative pain management such as physical therapy, massage and acupuncture, the researchers say.

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Depression, anxiety linked to opioid use and reduced survival in women with breast cancer

The findings should encourage doctors to better manage mental health in patients with breast cancer and spur care providers to consider alternative pain management such as physical therapy, massage and acupuncture, the researchers say.

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Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

Researchers show that heterogeneity of both breast cancer cells themselves and immune composition of the tumor microenvironment are important considerations for therapy.

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Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

Researchers show that heterogeneity of both breast cancer cells themselves and immune composition of the tumor microenvironment are important considerations for therapy.

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How gonorrhea develops resistance to antibiotics

As public health officials worry about the emergence of antibiotic-resistant gonorrhea, researchers are tracing how antibiotics bind to a gonococcal protein, information that can help lead to new antimicrobials.

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Scorpion toxin that targets 'wasabi receptor' may help solve mystery of chronic pain

Researchers have discovered a scorpion toxin that targets the 'wasabi receptor,' a chemical-sensing protein found in nerve cells that's responsible for the sinus-jolting sting of wasabi. Because the toxin triggers a pain response, scientists think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers.

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Scorpion toxin that targets 'wasabi receptor' may help solve mystery of chronic pain

Researchers have discovered a scorpion toxin that targets the 'wasabi receptor,' a chemical-sensing protein found in nerve cells that's responsible for the sinus-jolting sting of wasabi. Because the toxin triggers a pain response, scientists think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers.

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New pharmaceutical target reverses osteoporosis in mice

Biomedical engineers have discovered that an adenosine receptor called A2B can be pharmaceutically activated to reverse bone degradation caused by osteoporosis in mouse models of the disease.

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New pharmaceutical target reverses osteoporosis in mice

Biomedical engineers have discovered that an adenosine receptor called A2B can be pharmaceutically activated to reverse bone degradation caused by osteoporosis in mouse models of the disease.

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Parasite needs chemical (lipid/nutrient) in cat intestines for sex

Toxoplasma gondii is a microbial parasite that infects humans and but needs cats to complete its full life cycle. New research shows why: the sexual phase of the parasite's life cycle requires linoleic acid, a nutrient/lipid found at uniquely high levels in the felines, because cats lack a key enzyme for breaking it down.

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Repeated semen exposure promotes host resistance to infection in preclinical HIV model

Contrary to the long-held view that semen can only act as a way to transmit HIV-1 from men to women, scientists found that frequent and sustained semen exposure can change the characteristics of the circulating and vaginal tissue immune cells that are targets for infection, reducing the susceptibility to a future infection.

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Family history of diabetes linked to increased bone mineral density

The association between type 2 diabetes and increased fracture risk is well documented. However, little was known about the possible effect of family history of diabetes on bone mineral density (BMD). A study now confirms that a history of first-degree family members with diabetes is linked to increased BMD as well as to insulin resistance.

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Family history of diabetes linked to increased bone mineral density

The association between type 2 diabetes and increased fracture risk is well documented. However, little was known about the possible effect of family history of diabetes on bone mineral density (BMD). A study now confirms that a history of first-degree family members with diabetes is linked to increased BMD as well as to insulin resistance.

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What's at the 'heart' of a heartbeat?

A new finding has changed the understanding of the molecular mechanisms leading to atrial fibrillation.

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What's at the 'heart' of a heartbeat?

A new finding has changed the understanding of the molecular mechanisms leading to atrial fibrillation.

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Parent-targeted interventions in primary care improve parent-teen communication on alcohol and sex

New research shows that brief parent-targeted interventions in the primary care setting can increase communication between parents and their teens about sexual and alcohol-related behavior. This method may serve as an important strategy for parents to influence adolescent behaviors and health outcomes.

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MDM2 counteracts resistance to CDK4/6 inhibitors for melanoma therapy

A study has identified a possible second-line treatment for melanoma patients.

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Charcoal-based drug delivery system improves efficacy of common herpes drug

A study has found that combining acyclovir -- a commonly prescribed topical herpes medication -- with particles of activated carbon improves efficacy of the drug.

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Immune cells drive gallstone formation

Sticky meshworks of DNA and proteins extruded by white blood cells called neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation, researchers report. Both genetic and pharmacological approaches that inhibited the formation of these so-called neutrophil extracellular traps (NETs) reduced the formation and growth of gallstones in mice.

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Immune cells drive gallstone formation

Sticky meshworks of DNA and proteins extruded by white blood cells called neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation, researchers report. Both genetic and pharmacological approaches that inhibited the formation of these so-called neutrophil extracellular traps (NETs) reduced the formation and growth of gallstones in mice.

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Optimal vitamin D levels may vary for different ethnic and racial groups

When recommending vitamin D supplements, doctors should look at each individual patient as having different requirements and not rely on 'one-size-fits-all' guidelines, according to a new study.

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Type 2 diabetes and sleep problems in midlife women

Hormone changes are known to alter insulin sensitivity and glucose metabolism, as well as interfere with women's sleep patterns. But little was known about the association between diabetes and sleep disturbances during the menopause transition until now, as a new study concludes that women with diabetes are at greater risk for sleep disturbances.

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Optimal vitamin D levels may vary for different ethnic and racial groups

When recommending vitamin D supplements, doctors should look at each individual patient as having different requirements and not rely on 'one-size-fits-all' guidelines, according to a new study.

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Type 2 diabetes and sleep problems in midlife women

Hormone changes are known to alter insulin sensitivity and glucose metabolism, as well as interfere with women's sleep patterns. But little was known about the association between diabetes and sleep disturbances during the menopause transition until now, as a new study concludes that women with diabetes are at greater risk for sleep disturbances.

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Osteoporosis drugs linked to reduced risk of premature death

A large cohort study has revealed a common osteoporosis drug significantly decreases premature mortality risk, likely related to a reduction in bone loss.

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Osteoporosis drugs linked to reduced risk of premature death

A large cohort study has revealed a common osteoporosis drug significantly decreases premature mortality risk, likely related to a reduction in bone loss.

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Aspirin may help some breast cancer survivors, but changes in DNA may mean harm for others

Previous studies have shown that while some women who use aspirin and are later diagnosed with breast cancer may live longer, a portion of aspirin users with breast cancer appeared to have a higher risk of mortality following breast cancer. According to a new study, the reason for this reverse effect could be explained by DNA methylation of genes in breast cancer tumors or peripheral blood.

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Aspirin may help some breast cancer survivors, but changes in DNA may mean harm for others

Previous studies have shown that while some women who use aspirin and are later diagnosed with breast cancer may live longer, a portion of aspirin users with breast cancer appeared to have a higher risk of mortality following breast cancer. According to a new study, the reason for this reverse effect could be explained by DNA methylation of genes in breast cancer tumors or peripheral blood.

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Aspirin may help some breast cancer survivors, but changes in DNA may mean harm for others

Previous studies have shown that while some women who use aspirin and are later diagnosed with breast cancer may live longer, a portion of aspirin users with breast cancer appeared to have a higher risk of mortality following breast cancer. According to a new study, the reason for this reverse effect could be explained by DNA methylation of genes in breast cancer tumors or peripheral blood.

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Key to targeting the spread of pancreatic cancer

Targeting the tissue around pancreatic cancer cells may be the key to stopping their spread and improving chemotherapy outcomes.

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Artificial intelligence could yield more accurate breast cancer diagnoses

Researchers have developed an artificial intelligence system that could help pathologists read biopsies more accurately and to better detect and diagnose breast cancer.

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Artificial intelligence could yield more accurate breast cancer diagnoses

Researchers have developed an artificial intelligence system that could help pathologists read biopsies more accurately and to better detect and diagnose breast cancer.

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Artificial intelligence could yield more accurate breast cancer diagnoses

Researchers have developed an artificial intelligence system that could help pathologists read biopsies more accurately and to better detect and diagnose breast cancer.

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Teens feel pressured to get pregnant

Female adolescents are experiencing relationship abuse at alarming rates, according to a new study that specifically researched reproductive coercion - a form of abuse in which a woman is pressured to become pregnant against her wishes.

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New 'liquid biopsy' blood test improves breast cancer diagnostics

A new type of blood test for breast cancer could help avoid thousands of unnecessary surgeries and otherwise precisely monitor disease progression, according to a new study.

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Bone strength could be linked to when you reached puberty

A new study has linked bone strength to the timing of puberty.

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Bone strength could be linked to when you reached puberty

A new study has linked bone strength to the timing of puberty.

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Electromagnetic fields may hinder spread of breast cancer cells

Electromagnetic fields might help prevent some breast cancers from spreading to other parts of the body, new research has found. The study showed that low intensity electromagnetic fields hindered the mobility of specific breast cancer cells by preventing the formation of long, thin extensions at the edge of a migrating cancer cell.

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Gene mutation combo linked to common cancer in women

Researchers have identified a combination of two gene mutations that is linked to endometrial cancer.

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Gene mutation combo linked to common cancer in women

Researchers have identified a combination of two gene mutations that is linked to endometrial cancer.

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Substituting poultry for red meat may reduce breast cancer risk

Results from a new study suggest that red meat consumption may increase the risk of breast cancer, whereas poultry consumption may be protective against breast cancer risk.

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Substituting poultry for red meat may reduce breast cancer risk

Results from a new study suggest that red meat consumption may increase the risk of breast cancer, whereas poultry consumption may be protective against breast cancer risk.

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Substituting poultry for red meat may reduce breast cancer risk

Results from a new study suggest that red meat consumption may increase the risk of breast cancer, whereas poultry consumption may be protective against breast cancer risk.

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AI reveals new breast cancer types that respond differently to treatment

Scientists have used artificial intelligence to recognize patterns in breast cancer -- and uncovered five new types of the disease each matched to different personalized treatments.

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Can a combination immune therapy reduce genital herpes outbreaks?

Investigators have shown that the combination of a vaccine and a medicated cream is a promising strategy to dramatically reduce the recurrence of genital herpes.

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'Is it time for another contraception revolution?'

In an effort to protect the planet and preserve its natural treasures for future generations, another contraception revolution that provides options for populations not currently being served by modern contraception may be the answer according to the author of a new article.

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