Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Consumption of processed foods high in sugar and fat increase levels of advanced glycation end products (AGEs). Researchers report that AGE levels are higher in patients with estrogen receptor (ER)-positive than ER-negative breast cancer. Addition of AGEs caused breast cancer cells, whose growth had previously been controlled by tamoxifen, to begin to grow again. This suggests that patients with high AGEs may be less likely to respond to tamoxifen treatment.

from Women's Health News -- ScienceDaily http://bit.ly/2VjkXIj

Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Consumption of processed foods high in sugar and fat increase levels of advanced glycation end products (AGEs). Researchers report that AGE levels are higher in patients with estrogen receptor (ER)-positive than ER-negative breast cancer. Addition of AGEs caused breast cancer cells, whose growth had previously been controlled by tamoxifen, to begin to grow again. This suggests that patients with high AGEs may be less likely to respond to tamoxifen treatment.

from Women's Health News -- ScienceDaily http://bit.ly/2VjkXIj

Breaking down AGEs: Insight into how lifestyle drives ER-positive breast cancer

Consumption of processed foods high in sugar and fat increase levels of advanced glycation end products (AGEs). Researchers report that AGE levels are higher in patients with estrogen receptor (ER)-positive than ER-negative breast cancer. Addition of AGEs caused breast cancer cells, whose growth had previously been controlled by tamoxifen, to begin to grow again. This suggests that patients with high AGEs may be less likely to respond to tamoxifen treatment.

from Breast Cancer News -- ScienceDaily http://bit.ly/2VjkXIj

Breast cancer drugs could help treat resistant lung cancers

A class of drugs used to treat certain breast cancers could help to tackle lung cancers that have become resistant to targeted therapies, a new study suggests. The research found that lung tumors in mice caused by mutations in a gene called EGFR shrunk significantly when a certain protein was blocked.

from Breast Cancer News -- ScienceDaily http://bit.ly/2RhCVvA

Confronting the side effects of a common anti-cancer treatment

Results of a new study suggest that a new treatment approach is needed -- and how this may be possible -- to address adverse effects of aromatase inhibitors, drugs commonly prescribed to both men and women to prevent recurrence of estrogen-positive breast cancer.

from Women's Health News -- ScienceDaily http://bit.ly/2AiN4OA

Confronting the side effects of a common anti-cancer treatment

Results of a new study suggest that a new treatment approach is needed -- and how this may be possible -- to address adverse effects of aromatase inhibitors, drugs commonly prescribed to both men and women to prevent recurrence of estrogen-positive breast cancer.

from Women's Health News -- ScienceDaily http://bit.ly/2AiN4OA

A novel mechanism that regulates cellular injury by phagocytes during inflammation

Phagocytes such as macrophages and neutrophils contain multiple lysosomes, which possess a variety of digestive enzymes. Upon stimulation, phagocytes secrete these digestive enzymes through a process called lysosomal exocytosis to lyse external pathogens or tumor cells. A research team has identified myoferlin as a critical regulator of this process. Furthermore, they found that it plays an important role in inducing cellular injury by phagocytes during inflammation.

from Women's Health News -- ScienceDaily http://bit.ly/2Si7Vss

A novel mechanism that regulates cellular injury by phagocytes during inflammation

Phagocytes such as macrophages and neutrophils contain multiple lysosomes, which possess a variety of digestive enzymes. Upon stimulation, phagocytes secrete these digestive enzymes through a process called lysosomal exocytosis to lyse external pathogens or tumor cells. A research team has identified myoferlin as a critical regulator of this process. Furthermore, they found that it plays an important role in inducing cellular injury by phagocytes during inflammation.

from Women's Health News -- ScienceDaily http://bit.ly/2Si7Vss

Delivery method associated with pelvic floor disorders after childbirth

Research has demonstrated that vaginal childbirth substantially increases the probability a woman will develop a pelvic floor disorder later in life.

from Women's Health News -- ScienceDaily https://ift.tt/2QDP7ai

Delivery method associated with pelvic floor disorders after childbirth

Research has demonstrated that vaginal childbirth substantially increases the probability a woman will develop a pelvic floor disorder later in life.

from Women's Health News -- ScienceDaily https://ift.tt/2QDP7ai

How breast cancer avoids immune system detection

Researchers analyzed data from more than 1,000 breast cancer patients and found that breast cancer behaves differently than other cancers that are currently treated with immunotherapy. They identified seven clusters of breast cancer patients based on the immune evasion mechanisms that breast cancer uses to avoid detection.

from Breast Cancer News -- ScienceDaily https://ift.tt/2Sad31C

How breast cancer avoids immune system detection

Researchers analyzed data from more than 1,000 breast cancer patients and found that breast cancer behaves differently than other cancers that are currently treated with immunotherapy. They identified seven clusters of breast cancer patients based on the immune evasion mechanisms that breast cancer uses to avoid detection.

from Women's Health News -- ScienceDaily https://ift.tt/2Sad31C

How breast cancer avoids immune system detection

Researchers analyzed data from more than 1,000 breast cancer patients and found that breast cancer behaves differently than other cancers that are currently treated with immunotherapy. They identified seven clusters of breast cancer patients based on the immune evasion mechanisms that breast cancer uses to avoid detection.

from Women's Health News -- ScienceDaily https://ift.tt/2Sad31C

New epigenetic cervical cancer test has 100 per cent detection rate

A new test for cervical cancer was found to detect all of the cancers in a trial of 15,744 women, outperforming both the current Pap smear and human papillomavirus (HPV) test at a reduced cost, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2Brt7F9

New epigenetic cervical cancer test has 100 per cent detection rate

A new test for cervical cancer was found to detect all of the cancers in a trial of 15,744 women, outperforming both the current Pap smear and human papillomavirus (HPV) test at a reduced cost, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2Brt7F9

Treatment for underdiagnosed cause of debilitating chest pain

Researchers find an effective way to treat an underdiagnosed condition that can cause heart attack and heart-attack-like symptoms.

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Treatment for underdiagnosed cause of debilitating chest pain

Researchers find an effective way to treat an underdiagnosed condition that can cause heart attack and heart-attack-like symptoms.

from Women's Health News -- ScienceDaily https://ift.tt/2Ep0CLr

Control HIV by treating schistosomiasis, new study suggests

Of the 34 million people worldwide with HIV, and the 200 million with schistosomiasis, the majority live in Africa -- where millions of people are simultaneously infected with both diseases. Now, researchers have shown that schistosomiasis infections are associated with increased HIV onward transmission, HIV acquisition in HIV negative women with urogenital schistosomiasis, and progression to death in HIV positive women.

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Exercise-induced hormone irisin triggers bone remodeling in mice

Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice. A study identifies a receptor for irisin, an exercise hormone, and shows that irisin impacts sclerostin in mice, a major cellular regulator of bone structure in humans.

from Women's Health News -- ScienceDaily https://ift.tt/2EjGdav

Exercise-induced hormone irisin triggers bone remodeling in mice

Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice. A study identifies a receptor for irisin, an exercise hormone, and shows that irisin impacts sclerostin in mice, a major cellular regulator of bone structure in humans.

from Women's Health News -- ScienceDaily https://ift.tt/2EjGdav

Novel technique may significantly reduce breast biopsies

A novel technique that uses mammography to determine the biological tissue composition of a tumor could help reduce unnecessary breast biopsies, according to a new study.

from Breast Cancer News -- ScienceDaily https://ift.tt/2LdQnLa

Novel technique may significantly reduce breast biopsies

A novel technique that uses mammography to determine the biological tissue composition of a tumor could help reduce unnecessary breast biopsies, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2LdQnLa

Novel technique may significantly reduce breast biopsies

A novel technique that uses mammography to determine the biological tissue composition of a tumor could help reduce unnecessary breast biopsies, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2LdQnLa

Increased risk for breast cancer after childbirth may last more than 20 years

The increased risk for breast cancer that occurs after childbirth can last more than 20 years. The risk may be enhanced when a woman is older at first birth or has a family history of breast cancer, and is not mitigated by breastfeeding.

from Breast Cancer News -- ScienceDaily https://ift.tt/2Edw4wb

Increased risk for breast cancer after childbirth may last more than 20 years

The increased risk for breast cancer that occurs after childbirth can last more than 20 years. The risk may be enhanced when a woman is older at first birth or has a family history of breast cancer, and is not mitigated by breastfeeding.

from Women's Health News -- ScienceDaily https://ift.tt/2Edw4wb

Increased risk for breast cancer after childbirth may last more than 20 years

The increased risk for breast cancer that occurs after childbirth can last more than 20 years. The risk may be enhanced when a woman is older at first birth or has a family history of breast cancer, and is not mitigated by breastfeeding.

from Women's Health News -- ScienceDaily https://ift.tt/2Edw4wb

Sprayable gel could help the body fight off cancer after surgery

A research team has developed a spray gel embedded with immune-boosting drugs that could help lower the risk of cancer recurrence after surgery.

from Women's Health News -- ScienceDaily https://ift.tt/2C22qbv

Sprayable gel could help the body fight off cancer after surgery

A research team has developed a spray gel embedded with immune-boosting drugs that could help lower the risk of cancer recurrence after surgery.

from Women's Health News -- ScienceDaily https://ift.tt/2C22qbv

Imaging atomic structure of important immune regulator

A new study provides a biophysical and structural assessment of a critical immune regulating protein called human T-cell immunoglobulin and mucin domain containing protein-3 (hTIM-3). Understanding the atomic structure of hTIM-3 provides new insights for targeting this protein for numerous cancer and autoimmune therapeutics currently under clinical development.

from Women's Health News -- ScienceDaily https://ift.tt/2SCVlDN

Imaging atomic structure of important immune regulator

A new study provides a biophysical and structural assessment of a critical immune regulating protein called human T-cell immunoglobulin and mucin domain containing protein-3 (hTIM-3). Understanding the atomic structure of hTIM-3 provides new insights for targeting this protein for numerous cancer and autoimmune therapeutics currently under clinical development.

from Women's Health News -- ScienceDaily https://ift.tt/2SCVlDN

Insufficient nutrition during fetal development may lead to early menopause

Previous studies have demonstrated that fetal malnutrition can lead to adult chronic disorders such as type 2 diabetes and coronary artery disease. A new study out of China now suggests that it also can lead to early menopause and premature ovarian failure.

from Women's Health News -- ScienceDaily https://ift.tt/2EozkG3

Insufficient nutrition during fetal development may lead to early menopause

Previous studies have demonstrated that fetal malnutrition can lead to adult chronic disorders such as type 2 diabetes and coronary artery disease. A new study out of China now suggests that it also can lead to early menopause and premature ovarian failure.

from Women's Health News -- ScienceDaily https://ift.tt/2EozkG3

Circulating tumor cell count could help choose treatment for metastatic breast cancer patients

Circulating tumor-cell (CTC) count could be used to choose hormone therapy or chemotherapy as frontline treatment for patients with estrogen receptor-positive (ER+), HER2-negative (HER2-) metastatic breast cancer, according to data from the phase III STIC CTC clinical trial. In the case of discrepancy between CTC count-based treatment choice and physician's choice of treatment, frontline chemotherapy was associated with a significant gain in overall survival.

from Breast Cancer News -- ScienceDaily https://ift.tt/2zQdbwd

New imaging tools that trace key breast cancer enzymes may help guide therapies

A set of emerging diagnostic tools may help identify breast cancer patients who are most likely to benefit from therapies that target important enzymes fueling a range of subtypes, including BCRA-mutated and triple negative cancers.

from Breast Cancer News -- ScienceDaily https://ift.tt/2Ei0y10

New imaging tools that trace key breast cancer enzymes may help guide therapies

A set of emerging diagnostic tools may help identify breast cancer patients who are most likely to benefit from therapies that target important enzymes fueling a range of subtypes, including BCRA-mutated and triple negative cancers.

from Women's Health News -- ScienceDaily https://ift.tt/2Ei0y10

New imaging tools that trace key breast cancer enzymes may help guide therapies

A set of emerging diagnostic tools may help identify breast cancer patients who are most likely to benefit from therapies that target important enzymes fueling a range of subtypes, including BCRA-mutated and triple negative cancers.

from Women's Health News -- ScienceDaily https://ift.tt/2Ei0y10

Sex-specific effects of DHEA on bone mineral density and body composition

Women 55 and older have an increased risk of bone and muscle loss but therapy with the hormone Dehydroepiandrosterone (DHEA) may help prevent bone loss and increase muscle mass in older women, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2EcqbQL

Sex-specific effects of DHEA on bone mineral density and body composition

Women 55 and older have an increased risk of bone and muscle loss but therapy with the hormone Dehydroepiandrosterone (DHEA) may help prevent bone loss and increase muscle mass in older women, according to a new study.

from Women's Health News -- ScienceDaily https://ift.tt/2EcqbQL

Women reveal the reasons they reject a preventive drug for breast cancer

Only around a fifth of women at higher risk of developing breast cancer think they need to take a drug proven to help prevent the disease, according to new research.

from Breast Cancer News -- ScienceDaily https://ift.tt/2rkrMLy

Women reveal the reasons they reject a preventive drug for breast cancer

Only around a fifth of women at higher risk of developing breast cancer think they need to take a drug proven to help prevent the disease, according to new research.

from Women's Health News -- ScienceDaily https://ift.tt/2rkrMLy

Women reveal the reasons they reject a preventive drug for breast cancer

Only around a fifth of women at higher risk of developing breast cancer think they need to take a drug proven to help prevent the disease, according to new research.

from Women's Health News -- ScienceDaily https://ift.tt/2rkrMLy

Genetic background of autistic spectrum disorders with stem cell dysfunction

A recently completed study provides new information on functional changes in the brain connected with autistic spectrum disorders. The findings help identify factors related to the individual manifestation of autistic spectrum disorders and associated diseases.

from Women's Health News -- ScienceDaily https://ift.tt/2SsJo3M

Genetic background of autistic spectrum disorders with stem cell dysfunction

A recently completed study provides new information on functional changes in the brain connected with autistic spectrum disorders. The findings help identify factors related to the individual manifestation of autistic spectrum disorders and associated diseases.

from Women's Health News -- ScienceDaily https://ift.tt/2SsJo3M