Novel molecular mechanisms in the early development of diabetes mellitus

Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of Anxa10 expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated Anxa10 expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin secretory capacity.

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Urban environmental exposures drive increased breast cancer incidence

An analysis of breast cancer showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis.

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Urban environmental exposures drive increased breast cancer incidence

An analysis of breast cancer showed that the state’s urban counties had higher overall incidences of disease than rural counties, especially at early stages upon diagnosis.

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Reducing vitamin B5 slows breast cancer growth in mice

Researchers have discovered that breast cancer cells expressing a cancer-driving gene heavily rely on vitamin B5 to grow and survive.

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Higher risk of breast cancer in women with false positive mammography result

Women who receive a false positive mammography result are more likely to develop breast cancer over the subsequent 20 years, report researchers. The risk is highest for women aged between 60 and 75 and who have low breast density.

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Higher risk of breast cancer in women with false positive mammography result

Women who receive a false positive mammography result are more likely to develop breast cancer over the subsequent 20 years, report researchers. The risk is highest for women aged between 60 and 75 and who have low breast density.

from Women's Health News -- ScienceDaily https://ift.tt/H4y08ui

COVID vaccination in female, male partners does not increase risk of miscarriage, study finds

A new study provides deeper insight into the safety of COVID-19 vaccines for people planning to become pregnant. The study found no increased risk of early or late miscarriage as a result of male or female partners getting a COVID-19 vaccine prior to conceiving.

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Cutting-edge imaging sheds new light on cells that break down bone

Imaging technology shows that bone-resorbing osteoclasts gather in distinct pockets, leading to new insights for osteoporosis and cancer treatment.

from Women's Health News -- ScienceDaily https://ift.tt/oHPkK53

Nanoparticle vaccine could curb cancer metastasis to lungs by targeting a protein

Engineers have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs. Its success lies in targeting a protein known to play a central role in cancer growth and spread, rather than targeting the primary tumor itself.

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Researchers uncover mechanism that links NAD+ to fertility problems

A woman's fertility normally decreases by her late 30s with reproductive function eventually ceasing at menopause. It is known that a small molecule called nicotinamide adenine dinucleotide (NAD+) plays a critical role in this decline, and scientists have revealed how this happens and have identified potential new approaches to enhance reproductive longevity.

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