Rotavirus protein NSP4 manipulates gastrointestinal disease severity

Researchers have improved our understanding of how rotavirus, the most common cause of acute gastroenteritis in children, makes people sick. The study is among the first to show that the rotavirus protein NSP4 is both necessary and sufficient for multiple aspects of rotavirus infection by disrupting calcium signaling not only within infected cells but also in nearby uninfected cells. These disruptions in calcium signaling affect rotavirus disease severity, providing new insights into how NSP4's function influences rotavirus virulence. The findings suggest that manipulating NSP4 could lead to new strategies to prevent or treat rotavirus infections.

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Drug in clinical trials for breast cancer could also treat some blood cancers

Two new studies have identified a possible way to block the progression of several forms of blood cancer using a drug already in clinical trials against breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/RCYGp5Q

Cancer mortality continues to drop despite rising incidence in women

The American Cancer Society (ACS) today released Cancer Statistics, 2025, the organization's annual report on cancer facts and trends. The new findings show the cancer mortality rate declined by 34% from 1991 to 2022 in the United States, averting approximately 4.5 million deaths. However, this steady progress is jeopardized by increasing incidence for many cancer types, especially among women and younger adults, shifting the burden of disease. For example, incidence rates in women 50-64 years of age have surpassed those in men, and rates in women under 50 are now 82% higher than their male counterparts, up from 51% in 2002.

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Researchers resolve uncertainty in BRCA2 testing, improving cancer risk assessment and patient care

Findings from a multi-institutional, international study have significantly advanced the understanding of genetic alterations in the BRCA2 gene, a key player in hereditary cancer risk.

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Researchers boost chemotherapy uptake in breast cancer treatment with localized magnetic fields

Researchers have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects. By applying brief, localized pulses of magnetic fields, the team demonstrated a significant increase in the uptake of doxorubicin (DOX), a widely used chemotherapy drug, into breast cancer cells, with minimal impact on healthy tissues.

from Breast Cancer News -- ScienceDaily https://ift.tt/nla37qw

Researchers boost chemotherapy uptake in breast cancer treatment with localized magnetic fields

Researchers have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects. By applying brief, localized pulses of magnetic fields, the team demonstrated a significant increase in the uptake of doxorubicin (DOX), a widely used chemotherapy drug, into breast cancer cells, with minimal impact on healthy tissues.

from Women's Health News -- ScienceDaily https://ift.tt/nla37qw

Approaches against metastatic breast cancer: mini-tumors from circulating cancer cells

Tumor cells circulating in the blood are the 'germ cells' of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult. A team has now succeeded for the first time in cultivating stable tumor organoids directly from blood samples of breast cancer patients. Using these mini-tumors, the researchers were able to decipher a molecular signaling pathway that ensures the cancer cells' survival and resistance to therapy. With this knowledge, the team was able to develop an approach to specifically eliminate these tumor cells in lab experiments.

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Patients with heart disease may be at increased risk for advanced breast cancer

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

from Breast Cancer News -- ScienceDaily https://ift.tt/5O8fIXk

Patients with heart disease may be at increased risk for advanced breast cancer

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

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Achieving bone regeneration and adhesion with harmless visible light

A team develops an innovative injectable hydrogel for bone regeneration, addressing the limitations of traditional bone grafts and adhesion methods.

from Women's Health News -- ScienceDaily https://ift.tt/u0biAyq