Scientists discover key to preventing neurodegeneration in Parkinson's and related disorders

A team of researchers has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease. The team, led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, identified for the first time that unique RNA structures called G-quadruplexes (G4s) play a central role in promoting the aggregation of alpha-synuclein, a protein associated with neurodegeneration. By demonstrating that inhibiting G4 assembly could potentially prevent the onset of synucleinopathies, this discovery positions G4 as a promising target for early intervention in these diseases.

from Women's Health News -- ScienceDaily https://ift.tt/cKuPH31

Breast cancer: the diversity of metastases

A comprehensive analysis of breast cancer metastases compares various methods and affords new insights into the biology of tumors.

from Women's Health News -- ScienceDaily https://ift.tt/LVBcu5m

Breast cancer: the diversity of metastases

A comprehensive analysis of breast cancer metastases compares various methods and affords new insights into the biology of tumors.

from Breast Cancer News -- ScienceDaily https://ift.tt/LVBcu5m

Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

from Women's Health News -- ScienceDaily https://ift.tt/kr8YRQz

Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

from Breast Cancer News -- ScienceDaily https://ift.tt/kr8YRQz

Computational tool developed to predict immunotherapy outcomes for patients with metastatic breast cancer

Using computational tools, researchers have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy.

from Breast Cancer News -- ScienceDaily https://ift.tt/lKjS3iN

Novel role of BRCA1 in tumor suppression

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression.

from Breast Cancer News -- ScienceDaily https://ift.tt/t9uPycB

Clinical study confirms tissue stiffening in breast cancer can drive metastasis

Researchers evaluated tissues for fibrosis using MeCo Score, a diagnostic tool that can potentially predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.

from Women's Health News -- ScienceDaily https://ift.tt/laDHjIh

Clinical study confirms tissue stiffening in breast cancer can drive metastasis

Researchers evaluated tissues for fibrosis using MeCo Score, a diagnostic tool that can potentially predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/laDHjIh

Study highlights complexity of menopausal hormone therapy's impact on brain health

A study suggests that menopausal hormone therapy (MHT) might have moderate effects on brain health, but this depends on past surgical history, the duration of treatment, and a woman's age at last use.

from Women's Health News -- ScienceDaily https://ift.tt/qUnDx56