How ovarian tissue freezing could prevent menopause--possibly forever

Most women agree that menopause has its advantages and disadvantages. Some relish the end of menstruation and concerns about unplanned pregnancies, while others dread the possibililty of hot flashes, moodiness, and other unpleasant symptoms. What some women consider a brief and barely noticeable phase in their lives can evolve into lasting changes and discomfort for others. Now, a new paradigm around the biological processes of menopause is capturing the attention of a small group of scientists around the country. The primary question: can menopause be delayed in healthy women, allowing them to extend their child-bearing years -- and perhaps even forestall some of the health risks and uncomfortable symptoms linked to plummeting estrogen levels?

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Destroying tumor cells with calcium

Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell. An external calcium source is not necessary because only the calcium ions already present in the tumor tissue are used, according to a new study.

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Cold water swimming improves menopause symptoms

Menopausal women who regularly swim in cold water report significant improvements to their physical and mental symptoms, finds a new study.

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Walking fitness can predict fracture risk in older adults

The ability to walk one kilometer comfortably can help predict fracture risk, according to researchers. The findings suggest that simply asking a patient about walking limitation could allow clinicians to identify those in need of further bone health screening and prescribe interventions that could prevent fractures from occurring.

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Targeting annexin-A1 can halt cancer cell growth

A new study highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumor progression.

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Study pinpoints breast cancer 'cells of origin' in high-risk women

Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease. The study also showed these cells have potential to be targeted with an existing cancer drug to delay tumour growth, in findings that may lead to future preventive treatments for the disease.

from Breast Cancer News -- ScienceDaily https://ift.tt/jEZBUoe

Study pinpoints breast cancer 'cells of origin' in high-risk women

Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease. The study also showed these cells have potential to be targeted with an existing cancer drug to delay tumour growth, in findings that may lead to future preventive treatments for the disease.

from Women's Health News -- ScienceDaily https://ift.tt/jEZBUoe

Energy-starved breast cancer cells consume their surroundings for fuel

Breast cancer cells ingest and consume the matrix surrounding them to overcome starvation, according to a new study. The finding elucidates a previously unknown mechanism of cancer cell survival, and may offer a new target for therapy development.

from Breast Cancer News -- ScienceDaily https://ift.tt/UzfH8Cu

Metastatic breast cancer treatments have aided decline in deaths

Treatment of metastatic disease is responsible for nearly one-third of the decrease in annual deaths from breast cancer from 1975 to 2019, according to a new study.

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Method improves detection of potential therapeutic tumor targets in human biopsies

Researchers report the development of a methodology to detect small amounts of potential tumor therapeutic targets, specificacally enzymes called kinases, that are present in biopsy samples. Therapies that directly inhibit cancer-promoting activities of some of these kinases have proven to be effective for patients in which individual driving kinases can be diagnosed.

from Breast Cancer News -- ScienceDaily https://ift.tt/PcfJh3q