Targeting annexin-A1 can halt cancer cell growth

A new study highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumor progression.

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Study pinpoints breast cancer 'cells of origin' in high-risk women

Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease. The study also showed these cells have potential to be targeted with an existing cancer drug to delay tumour growth, in findings that may lead to future preventive treatments for the disease.

from Breast Cancer News -- ScienceDaily https://ift.tt/jEZBUoe

Study pinpoints breast cancer 'cells of origin' in high-risk women

Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease. The study also showed these cells have potential to be targeted with an existing cancer drug to delay tumour growth, in findings that may lead to future preventive treatments for the disease.

from Women's Health News -- ScienceDaily https://ift.tt/jEZBUoe

Energy-starved breast cancer cells consume their surroundings for fuel

Breast cancer cells ingest and consume the matrix surrounding them to overcome starvation, according to a new study. The finding elucidates a previously unknown mechanism of cancer cell survival, and may offer a new target for therapy development.

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Metastatic breast cancer treatments have aided decline in deaths

Treatment of metastatic disease is responsible for nearly one-third of the decrease in annual deaths from breast cancer from 1975 to 2019, according to a new study.

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Method improves detection of potential therapeutic tumor targets in human biopsies

Researchers report the development of a methodology to detect small amounts of potential tumor therapeutic targets, specificacally enzymes called kinases, that are present in biopsy samples. Therapies that directly inhibit cancer-promoting activities of some of these kinases have proven to be effective for patients in which individual driving kinases can be diagnosed.

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Incontinence could point to future disability

Having more frequent urinary incontinence and leakage amounts is associated with higher odds of disability, according to researchers.

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Natural compounds derived from soy and other plants reduce breast cancer recurrence and improve survival

Soy compounds called isoflavones are among the plant-derived compounds that may significantly reduce the risk of breast cancer recurrence or death, according to a new meta-analysis.

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Epigenetic therapy shows promise for endocrine-resistant breast cancer

Researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.

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Infertility: Sperm need a breakthrough for fertilization

A new study identifies the defective function of CatSper, an ion channel controlling calcium levels in sperm, as a common cause of seemingly unexplained male infertility. CatSper-deficient human sperm fail to fertilize the egg, because they cannot penetrate its protective vestments. Thus far, this sperm channelopathy has remained undetectable. Scientists have unravelled CatSper's role in infertility using a novel laboratory test that identifies affected men.

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