Method improves detection of potential therapeutic tumor targets in human biopsies

Researchers report the development of a methodology to detect small amounts of potential tumor therapeutic targets, specificacally enzymes called kinases, that are present in biopsy samples. Therapies that directly inhibit cancer-promoting activities of some of these kinases have proven to be effective for patients in which individual driving kinases can be diagnosed.

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Incontinence could point to future disability

Having more frequent urinary incontinence and leakage amounts is associated with higher odds of disability, according to researchers.

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Natural compounds derived from soy and other plants reduce breast cancer recurrence and improve survival

Soy compounds called isoflavones are among the plant-derived compounds that may significantly reduce the risk of breast cancer recurrence or death, according to a new meta-analysis.

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Epigenetic therapy shows promise for endocrine-resistant breast cancer

Researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.

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Infertility: Sperm need a breakthrough for fertilization

A new study identifies the defective function of CatSper, an ion channel controlling calcium levels in sperm, as a common cause of seemingly unexplained male infertility. CatSper-deficient human sperm fail to fertilize the egg, because they cannot penetrate its protective vestments. Thus far, this sperm channelopathy has remained undetectable. Scientists have unravelled CatSper's role in infertility using a novel laboratory test that identifies affected men.

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Reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth.

from Women's Health News -- ScienceDaily https://ift.tt/tWBH28j

Reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth.

from Breast Cancer News -- ScienceDaily https://ift.tt/tWBH28j

Calcium channel blockers key to reversing myotonic dystrophy muscle weakness

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease. The researchers believe this class of drugs, widely used to treat a number of cardiovascular diseases, hold promise as a future treatment for DM1.

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Manipulation of gut microbiota with flaxseed could reduce breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. 

from Breast Cancer News -- ScienceDaily https://ift.tt/dowSFGb

Manipulation of gut microbiota with flaxseed could reduce breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. 

from Women's Health News -- ScienceDaily https://ift.tt/dowSFGb