Epigenetic therapy shows promise for endocrine-resistant breast cancer

Researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.

from Breast Cancer News -- ScienceDaily https://ift.tt/OcUbmG1

Infertility: Sperm need a breakthrough for fertilization

A new study identifies the defective function of CatSper, an ion channel controlling calcium levels in sperm, as a common cause of seemingly unexplained male infertility. CatSper-deficient human sperm fail to fertilize the egg, because they cannot penetrate its protective vestments. Thus far, this sperm channelopathy has remained undetectable. Scientists have unravelled CatSper's role in infertility using a novel laboratory test that identifies affected men.

from Women's Health News -- ScienceDaily https://ift.tt/suOWgl5

Reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth.

from Women's Health News -- ScienceDaily https://ift.tt/tWBH28j

Reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth.

from Breast Cancer News -- ScienceDaily https://ift.tt/tWBH28j

Calcium channel blockers key to reversing myotonic dystrophy muscle weakness

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease. The researchers believe this class of drugs, widely used to treat a number of cardiovascular diseases, hold promise as a future treatment for DM1.

from Women's Health News -- ScienceDaily https://ift.tt/g6yCVW7

Manipulation of gut microbiota with flaxseed could reduce breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. 

from Breast Cancer News -- ScienceDaily https://ift.tt/dowSFGb

Manipulation of gut microbiota with flaxseed could reduce breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. 

from Women's Health News -- ScienceDaily https://ift.tt/dowSFGb

Early life gene epimutation may cause breast cancer

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene, called BRCA1. 

from Women's Health News -- ScienceDaily https://ift.tt/lm5i2L3

Early life gene epimutation may cause breast cancer

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene, called BRCA1. 

from Breast Cancer News -- ScienceDaily https://ift.tt/lm5i2L3

Blood hormone levels key to identifying which post-menopausal women will benefit most from taking anastrozole to prevent breast cancer

has found that hormone levels, measured through blood tests, are an important indicator of whether women will benefit from recently licensed medication for the prevention of breast cancer.

from Breast Cancer News -- ScienceDaily https://ift.tt/nGP7DRS