Review of over 70 years of menopause science highlights research gaps and calls for individualized treatment

Although about half of people go through menopause, less than 15% of them receive effective treatment for their symptoms. Treatment options for people experiencing irritating or severe menopause symptoms are often under researched, and some have questionable efficacy, or cause harmful side effects. Menopause experts now summarize what we know about menopause, call for more research into the timeline and treatment of menopause, and encourage individualized, holistic treatment that addresses both menopausal symptoms and other systemic changes happening in the body.

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'Gates of Heaven' calcium channel drives oral cancer pain and growth

An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study. Targeting this protein -- the ORAI1 calcium channel -- could provide a new approach to treating oral cancer, which causes persistent pain that worsens as it progresses.

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AI performs comparably to human readers of mammograms

Using a standardized assessment, researchers in the UK compared the performance of a commercially available artificial intelligence algorithm with human readers of screening mammograms.

from Breast Cancer News -- ScienceDaily https://ift.tt/3XSRynh

AI performs comparably to human readers of mammograms

Using a standardized assessment, researchers in the UK compared the performance of a commercially available artificial intelligence algorithm with human readers of screening mammograms.

from Women's Health News -- ScienceDaily https://ift.tt/3XSRynh

Software analyzes calcium 'sparks' that can contribute to arrhythmia

Researchers developed a new software tool, SparkMaster 2, that allows scientists to analyze normal and abnormal calcium activity in cells.

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New genes and natural toxins offer hope for cancer patients unresponsive to chemotherapy

Scientists have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive to chemotherapy subsequently respond to it.

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Unraveling the long history of breast cancer formation

The mechanism by which breast cancer is formed in the cells of mammalian epithelium has been discovered. Although roughly 20 mutations accumulate annually in each epithelial cell until menopause, the mutation rate significantly decreases after menopause. Accumulation also decreased after childbirth, suggesting the effect of estrogen in mammary epithelium.

from Women's Health News -- ScienceDaily https://ift.tt/iWsQY5p

Unraveling the long history of breast cancer formation

The mechanism by which breast cancer is formed in the cells of mammalian epithelium has been discovered. Although roughly 20 mutations accumulate annually in each epithelial cell until menopause, the mutation rate significantly decreases after menopause. Accumulation also decreased after childbirth, suggesting the effect of estrogen in mammary epithelium.

from Breast Cancer News -- ScienceDaily https://ift.tt/iWsQY5p

Estrogen-negative cancers respond to anti-estrogenic therapies

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

from Breast Cancer News -- ScienceDaily https://ift.tt/EHN8jMn

Estrogen-negative cancers respond to anti-estrogenic therapies

Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.

from Women's Health News -- ScienceDaily https://ift.tt/EHN8jMn