This frog bacterium wiped out cancer tumors in mice with a single dose

A naturally occurring bacterium from amphibian intestines completely eliminated colorectal tumors in mice with a single treatment by both attacking cancer cells and activating the immune system. The findings point to a promising new type of cancer therapy that could one day work against many solid tumors.

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A hidden immune backup system could supercharge mRNA cancer vaccines

Researchers found that mRNA cancer vaccines can recruit an unexpected immune cell to launch powerful tumor-fighting responses, overturning a long-held assumption about how the vaccines work. The discovery could lead to more effective cancer vaccines and help scientists tailor treatments for better patient outcomes.

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Tiny silica particles wiped out aggressive prostate cancer in mice

Tiny silica nanoparticles engineered to seek out prostate cancer caused tumor cells to self-destruct and supercharged the immune system in preclinical mouse studies. Combined with immunotherapy, the treatment produced complete remissions in multiple mice, raising hopes for a powerful new approach to prostate cancer.

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Creatine doesn't just build muscle. It may also help fight cancer

Scientists have discovered that creatine may strengthen one of the immune system's most important cancer-fighting pathways by energizing dendritic cells that activate killer T cells. The promising results could eventually help make immunotherapy more effective, but they have not yet been tested in human patients.

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Scientists discover how colon cancer cells change identity to spread

Scientists have identified a molecular switch that may help explain how colorectal cancer becomes deadly. When levels of a gene-regulating factor called GATA6 drop, cancer cells can shed their normal identity and transform into highly adaptable, fetal-like cells capable of spreading through the bloodstream and establishing new tumors in the liver. The study suggests that this dangerous transition is driven less by new genetic mutations and more by changes in how genes are switched on and off.

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Scientists found a surprising cancer fighter hiding inside tumors

Scientists at the University of Illinois Chicago have turned an unlikely source into a potential new weapon against cancer: bacteria that naturally live inside tumors. They developed a peptide called aurB, inspired by a bacterial protein, that infiltrates cancer cells and effectively cuts off their energy supply by targeting the mitochondria—the cells’ power plants.

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Scientists found 45 chemicals in pregnant women and many were linked to birth risks

A large study found that pregnant women are exposed to dozens of common chemicals, many of which were associated with earlier births and lower birth weights. Researchers also discovered that some replacement chemicals may be just as concerning as the substances they were designed to replace.

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Light switch wakes sleeping cancer cells and makes them vulnerable again

Some cancer cells evade treatment by entering a dormant state triggered by stress hormones. ETH Zurich scientists have created a light-controlled molecular switch that selectively destroys the receptors responsible for this survival mode. In laboratory lung cancer cells, the approach woke sleeping tumor cells and could help make future cancer therapies more effective while minimizing damage to healthy tissue.

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Millions take omega-3 fish oil for brain health but a new study found no benefit

Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.

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New vitamin B12 therapy shows promise against deadly brain cancer

Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.

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FDA-approved drug may finally help immunotherapy defeat rare liver cancer

Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.

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Osteopenia is silently weakening bones in millions of people

Osteopenia is a common but often overlooked condition that causes bones to become less dense and more fragile. Because it develops silently, many people only discover they have it after a fracture or bone scan. Aging, menopause, poor diet, and inactivity can all contribute to bone loss. Fortunately, exercise, adequate calcium and vitamin D, and other healthy habits can slow or even partially reverse the decline.

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This emerging treatment is helping people avoid knee replacement surgery

A minimally invasive treatment called GAE is helping people with chronic knee pain get back to gardening, cycling, and other activities without undergoing knee replacement surgery. Early studies suggest the procedure can provide years of relief by reducing inflammation inside the joint.

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This DNA repair gene went rogue and exposed a cancer weakness

Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help repair DNA, but when overproduced it starts cutting DNA it shouldn't, creating damage linked to cancer.

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A surprising discovery reveals the kidney has a secret backup system

Scientists at Mayo Clinic have uncovered a surprising new way the kidneys conserve water, revealing a hidden backup system that works independently of the hormone long believed to control the process. The discovery emerged when researchers testing an old drug called probenecid expected it to worsen polycystic kidney disease (PKD) but found it actually slowed cyst growth instead.

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New procedure delivers lasting knee arthritis pain relief without surgery

A minimally invasive treatment that blocks inflammation-driving blood vessels in the knee provided significant pain relief and improved function for osteoarthritis patients, with benefits lasting at least a year. The procedure was safe, highly successful, and could offer a new alternative for people seeking relief before considering knee replacement.

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Millions take calcium and vitamin D for stronger bones. A major review finds little benefit

For years, calcium and vitamin D supplements have been promoted as a simple way for older adults to protect their bones and prevent falls. But a massive review of nearly 154,000 people found that calcium, vitamin D, or a combination of both provided little to no meaningful protection against fractures or falls for most older adults.

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New fentanyl vaccine blocks deadly overdoses before they start

A new experimental vaccine developed by Scripps Research could offer a powerful new way to prevent fentanyl overdoses by stopping the drug before it reaches the brain. Rather than targeting only fentanyl itself, the vaccine trains the immune system to recognize a broad range of fentanyl-related designer drugs, including some of the most dangerous variants.

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Stanford scientists regrow lost cartilage and reverse arthritis in major breakthrough

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them.

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AI-designed universal coronavirus vaccine passes first human trial

Scientists have successfully tested an AI-designed universal coronavirus vaccine in humans for the first time, finding it to be safe and well tolerated. The vaccine generated immune responses against multiple coronaviruses, including SARS-CoV-2, SARS, and related bat viruses with pandemic potential. By targeting features shared across an entire virus family, it aims to provide protection even as viruses evolve.

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