Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

from Women's Health News -- ScienceDaily https://ift.tt/kr8YRQz

Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

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Computational tool developed to predict immunotherapy outcomes for patients with metastatic breast cancer

Using computational tools, researchers have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy.

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Novel role of BRCA1 in tumor suppression

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression.

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Clinical study confirms tissue stiffening in breast cancer can drive metastasis

Researchers evaluated tissues for fibrosis using MeCo Score, a diagnostic tool that can potentially predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.

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Clinical study confirms tissue stiffening in breast cancer can drive metastasis

Researchers evaluated tissues for fibrosis using MeCo Score, a diagnostic tool that can potentially predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.

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Study highlights complexity of menopausal hormone therapy's impact on brain health

A study suggests that menopausal hormone therapy (MHT) might have moderate effects on brain health, but this depends on past surgical history, the duration of treatment, and a woman's age at last use.

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Why breast cancer spreads to bone

Researchers have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis.

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Why breast cancer spreads to bone

Researchers have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis.

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New therapeutic strategy identified for triple negative breast cancer

Triple negative breast cancer (TNBC) remains the most aggressive and deadly type of breast cancer, but new findings from cancer researchers are pointing the way toward therapeutic strategies that could be tested in clinical trials in the future. Using patient-derived samples in pre-clinical work, researchers discovered that by combining two therapeutic agents they could nudge TNBC cells into a more treatable state.

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New therapeutic strategy identified for triple negative breast cancer

Triple negative breast cancer (TNBC) remains the most aggressive and deadly type of breast cancer, but new findings from cancer researchers are pointing the way toward therapeutic strategies that could be tested in clinical trials in the future. Using patient-derived samples in pre-clinical work, researchers discovered that by combining two therapeutic agents they could nudge TNBC cells into a more treatable state.

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Protein blocking bone development could hold clues for future osteoporosis treatment

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

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Keeping it together: How calcium signals help cells bury their dead neighbors

Dying cells are typically expelled from epithelial sheets to prevent foreign substances and microorganisms from entering, but the mechanism underlying this process is unclear. A recent study has revealed a calcium-mediated mechanism essential for surrounding cells to expel an adjacent dying cell. Their findings clarify various aspects of this intricate process, which could enhance our understanding of epithelial pathologies such as atopic dermatitis and inflammatory bowel disease.

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Common breast cancer treatments may speed aging process

Markers of cellular aging -- such as DNA damage response, cellular senescence, and inflammatory pathways -- significantly increased in all breast cancer survivors, regardless of the type of treatment received.

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Do people with MS have an increased risk of cancer?

A new study has found some cancers to be slightly more frequent in people with multiple sclerosis (MS) than in people without MS. Types of cancers found to have a small increased risk include bladder, brain and cervical cancers. The study does not prove that MS increases a person's risk of cancer. It only shows an association.

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Scientists discover that special immune cells stop metastatic cancer

Researchers have discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body.

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Scientist develops new model for ovarian cancer -- with crossover to uterine cancer

Researchers say that in the course of developing a new model for ovarian cancer, they've developed additional evidence that serous uterine cancer possibly begins in the fallopian tubes, not the uterus.

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Role of ophthalmic acid in motor function control

A research team has revealed that a molecule in the brain -- ophthalmic acid -- unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson's and other movement diseases.

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How estrogen's millisecond-fast action happens

Researchers discovered a mechanism by which estrogen can trigger fast neuronal responses.

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