Destroying tumor cells with calcium

Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell. An external calcium source is not necessary because only the calcium ions already present in the tumor tissue are used, according to a new study.

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Cold water swimming improves menopause symptoms

Menopausal women who regularly swim in cold water report significant improvements to their physical and mental symptoms, finds a new study.

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Walking fitness can predict fracture risk in older adults

The ability to walk one kilometer comfortably can help predict fracture risk, according to researchers. The findings suggest that simply asking a patient about walking limitation could allow clinicians to identify those in need of further bone health screening and prescribe interventions that could prevent fractures from occurring.

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Targeting annexin-A1 can halt cancer cell growth

A new study highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumor progression.

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Study pinpoints breast cancer 'cells of origin' in high-risk women

Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease. The study also showed these cells have potential to be targeted with an existing cancer drug to delay tumour growth, in findings that may lead to future preventive treatments for the disease.

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Study pinpoints breast cancer 'cells of origin' in high-risk women

Australian scientists have pinpointed likely 'cells of origin', the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease. The study also showed these cells have potential to be targeted with an existing cancer drug to delay tumour growth, in findings that may lead to future preventive treatments for the disease.

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Energy-starved breast cancer cells consume their surroundings for fuel

Breast cancer cells ingest and consume the matrix surrounding them to overcome starvation, according to a new study. The finding elucidates a previously unknown mechanism of cancer cell survival, and may offer a new target for therapy development.

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Metastatic breast cancer treatments have aided decline in deaths

Treatment of metastatic disease is responsible for nearly one-third of the decrease in annual deaths from breast cancer from 1975 to 2019, according to a new study.

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Method improves detection of potential therapeutic tumor targets in human biopsies

Researchers report the development of a methodology to detect small amounts of potential tumor therapeutic targets, specificacally enzymes called kinases, that are present in biopsy samples. Therapies that directly inhibit cancer-promoting activities of some of these kinases have proven to be effective for patients in which individual driving kinases can be diagnosed.

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Incontinence could point to future disability

Having more frequent urinary incontinence and leakage amounts is associated with higher odds of disability, according to researchers.

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Natural compounds derived from soy and other plants reduce breast cancer recurrence and improve survival

Soy compounds called isoflavones are among the plant-derived compounds that may significantly reduce the risk of breast cancer recurrence or death, according to a new meta-analysis.

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Epigenetic therapy shows promise for endocrine-resistant breast cancer

Researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.

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Infertility: Sperm need a breakthrough for fertilization

A new study identifies the defective function of CatSper, an ion channel controlling calcium levels in sperm, as a common cause of seemingly unexplained male infertility. CatSper-deficient human sperm fail to fertilize the egg, because they cannot penetrate its protective vestments. Thus far, this sperm channelopathy has remained undetectable. Scientists have unravelled CatSper's role in infertility using a novel laboratory test that identifies affected men.

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Reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth.

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Reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown that p53-mutated mouse breast cancer cells reprogram fat cells. The manipulated fat cells create an inflammatory microenvironment, impairing the immune response against the tumor and thus promoting cancer growth.

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Calcium channel blockers key to reversing myotonic dystrophy muscle weakness

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease. The researchers believe this class of drugs, widely used to treat a number of cardiovascular diseases, hold promise as a future treatment for DM1.

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