Study explores whether CBD can reduce scan-related anxiety in patients with advanced breast cancer

A new study explores whether cannabidiol (CBD), a component of marijuana, can reduce anxiety levels, specifically among patients with advanced breast cancer before a scan assessing tumor burden.

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Researchers reveal mechanisms underlying Sjögren's disease

Researchers are closer to understanding what drives the autoimmune disorder Sj gren's disease, thanks to new discoveries about the role of calcium signaling, regulatory T cells, and interferon. Their latest study finds that impaired regulatory T cells are a critical contributing factor to Sj gren's disease in both mice and humans, and identifies an existing rheumatology drug as a promising therapy for the disease.

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Tiny robots, big impact: Revolutionizing infertility treatment with magnetic microrobots

Infertility affects an estimated 186 million people worldwide, with fallopian tube obstruction contributing to 11%-67% of female infertility cases. Researchers have developed an innovative solution using a magnetically driven robotic microscrew to treat fallopian tube blockages. The microrobot is made from nonmagnetic photosensitive resin, coated with a thin iron layer to give it magnetic properties. By applying an external magnetic field, the robot rotates, generating translational motion that enables it to navigate through a glass channel simulating a fallopian tube.

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First full characterization of kidney microbiome unlocks potential to prevent kidney stones

Researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal. The publication describes the rigorous multi-pronged approach a team used to identify and characterize the small bacterial community by combining preclinical, human and dish studies.

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AI-powered blood test first to spot earliest sign of breast cancer

A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.

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New method could improve cervical cancer screening

Analyses of self-tests for human papillomavirus (HPV) can be used to divide HPV-positive women into three risk groups, according to a new study. This method could be important for enhancing cervical cancer screening.

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The genetic basis of fertility, family and longevity

A new review reveals how your DNA shapes reproductive health, fertility, and even life expectancy.

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AI-powered blood test first to spot earliest sign of breast cancer

A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.

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Artificial intelligence improves mammography-based risk prediction

The future of breast cancer screening and risk-reducing strategies is being shaped by artificial intelligence (AI), according to a recent review article.

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Artificial intelligence improves mammography-based risk prediction

The future of breast cancer screening and risk-reducing strategies is being shaped by artificial intelligence (AI), according to a recent review article.

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Hair growth drug safe at low doses for breast cancer patients

Oral minoxidil is a commonly prescribed treatment for hair loss. The drug is also the active ingredient in over-the-counter Rogaine. The prescription treatment is known, however, to dilate blood vessels, and experts worry that this could increase the heart-related side effects of chemotherapy and lead to chest pain, shortness of breath, or fluid buildup. Now, a study in women with breast cancer suggests that low oral doses of minoxidil, taken during or after cancer treatment, appear to regrow hair in most patients and without causing any serious heart-related side effects that require additional therapies or hospitalization.

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Americans are uninformed about and undervaccinated for HPV

Research shows that HPV accounts for 70% of all throat cancers, but only one-third of the public is aware that HPV causes throat cancer.

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Researchers discover a genetic disposition increasing the risk of breast cancer metastasis

Metastasis is responsible for 90 percent of cancer deaths. Researchers have found that the mutations driving it may stem from a commonly inherited variant of the PCSK9 gene.

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AI-enabled analysis of images meant to catch one disease can reveal others

With the help of an AI tool, computed tomography (CT) scans taken originally to look for tumors or bleeding or infections, also revealed calcium buildup in arteries, a sign of worsening cardiovascular disease.

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In five cancer types, prevention and screening have been major contributors to saving lives

Improvements in cancer prevention and screening have averted more deaths from five cancer types combined over the past 45 years than treatment advances, according to a modeling study led by researchers at the National Institutes of Health (NIH). The study looked at deaths from breast, cervical, colorectal, lung, and prostate cancer that were averted by the combination of prevention, screening, and treatment advances.

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Analyzing multiple mammograms improves breast cancer risk prediction

A new method of analyzing mammograms identified individuals at high risk of developing breast cancer more accurately than the standard, questionnaire-based method did. The new method, powered by artificial intelligence, could help diagnose cancer earlier and guide recommendations for earlier screening, additional imaging or risk-reducing medications.

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Analyzing multiple mammograms improves breast cancer risk prediction

A new method of analyzing mammograms identified individuals at high risk of developing breast cancer more accurately than the standard, questionnaire-based method did. The new method, powered by artificial intelligence, could help diagnose cancer earlier and guide recommendations for earlier screening, additional imaging or risk-reducing medications.

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How breast cancer cells survive in bone marrow after remission

A new study has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.

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How breast cancer cells survive in bone marrow after remission

A new study has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.

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Long-term benefit from anti-hormonal treatment is influenced by menopausal status

Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause.

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Long-term benefit from anti-hormonal treatment is influenced by menopausal status

Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause.

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Scientists identify brain cell type as master controller of urination

Researchers have identified a subset of brain cells in mice that act as the master regulators of urination.

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Different menopausal hormone treatments pose different risks

Researchers have analysed the effects of seven different hormone treatments for menopausal symptoms on the risk of blood clots, stroke and heart attack. The study, which involved around one million women aged between 50 and 58, is the largest and most comprehensive study of currently prescribed hormonal substances in the world. The results show that the risks differ depending on the active substance and how the medicine is taken.

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Cervical cancer deaths in young women plummet after introduction of HPV vaccine

Researchers found a reduction in cervical cancer mortality in women under the age of 25, which is likely due to the introduction of the HPV vaccine.

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Scientists find why tamoxifen works better for some people

Tamoxifen is a common and important treatment to prevent breast cancer from recurring. A new study shows that variation in a patient's gut microbiome can impact how effective the treatment is.

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Short-term menopausal hormone therapy has no long-term cognitive impact, study finds

Short-term menopausal hormone therapy (MHT) did not have long-term cognitive effects when given to women in early postmenopause, according to a new study.

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Cancer-like mutations in healthy cells point to origins of breast cancer

Researchers have pinpointed what could be the early genetic origins of breast cancer -- cancer-like mutations appearing in the cells of healthy women. In a new study, the international collaborators analyzed the genomes of more than 48,000 individual breast cells from women without cancer, using novel techniques for decoding the genes of single cells. While the vast majority of cells appeared normal, nearly all of the women harbored a small number of breast cells -- about 3 per cent -- that carried genetic alterations commonly associated with cancer. The findings suggest that these rare genetic anomalies may represent some of the earliest steps in a series of events that could culminate in breast cancer development.

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Healthy women have cells that resemble breast cancer

A new study finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods. The study discovered that at least 3% of normal cells from breast tissue in 49 healthy women contain a gain or loss of chromosomes, a condition known as aneuploidy, and that they expand and accumulate with age.

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A new discovery about pain signaling may contribute to better treatment of chronic pain

When pain signals are passed along the nervous system, proteins called calcium channels play a key role. Researchers have now pinpointed the exact location of a specific calcium channel fine-tuning the strength of pain signals. This knowledge can be used to develop drugs for chronic pain that are more effective and have fewer side effects.

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Synthetic cells emulate natural cellular communication

A research team has succeeded in synthesizing simple, environmentally sensitive cells complete with artificial organelles. For the first time, the researchers have also been able to emulate natural cell-cell communication using these proto-cells -- based on the model of photoreceptors in the eye. This opens up new possibilities for basic research and applications in medicine.

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Super microscope shows nanoscale biological process for the first time

A new microscope is capable of live imaging of biological processes in such detail that moving protein complexes are visible.

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Vitamin D during pregnancy boosts children's bone health even at age seven

Children whose mothers took extra vitamin D during pregnancy continue to have stronger bones at age seven, according to research.

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Scientists discover key to preventing neurodegeneration in Parkinson's and related disorders

A team of researchers has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease. The team, led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, identified for the first time that unique RNA structures called G-quadruplexes (G4s) play a central role in promoting the aggregation of alpha-synuclein, a protein associated with neurodegeneration. By demonstrating that inhibiting G4 assembly could potentially prevent the onset of synucleinopathies, this discovery positions G4 as a promising target for early intervention in these diseases.

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Breast cancer: the diversity of metastases

A comprehensive analysis of breast cancer metastases compares various methods and affords new insights into the biology of tumors.

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Breast cancer: the diversity of metastases

A comprehensive analysis of breast cancer metastases compares various methods and affords new insights into the biology of tumors.

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Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

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Complexity of tumors revealed in 3D

A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor's surrounding environment -- are organized, in 3D, and how that organization changes when a tumor spreads to other organs. The detailed findings offer scientists valuable blueprints of tumors that could lead to new approaches to therapy and spark a new era in the field of cancer biology, according to the researchers.

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Computational tool developed to predict immunotherapy outcomes for patients with metastatic breast cancer

Using computational tools, researchers have developed a method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy.

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Novel role of BRCA1 in tumor suppression

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression.

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Clinical study confirms tissue stiffening in breast cancer can drive metastasis

Researchers evaluated tissues for fibrosis using MeCo Score, a diagnostic tool that can potentially predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.

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Clinical study confirms tissue stiffening in breast cancer can drive metastasis

Researchers evaluated tissues for fibrosis using MeCo Score, a diagnostic tool that can potentially predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.

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Study highlights complexity of menopausal hormone therapy's impact on brain health

A study suggests that menopausal hormone therapy (MHT) might have moderate effects on brain health, but this depends on past surgical history, the duration of treatment, and a woman's age at last use.

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Why breast cancer spreads to bone

Researchers have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis.

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Why breast cancer spreads to bone

Researchers have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis.

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New therapeutic strategy identified for triple negative breast cancer

Triple negative breast cancer (TNBC) remains the most aggressive and deadly type of breast cancer, but new findings from cancer researchers are pointing the way toward therapeutic strategies that could be tested in clinical trials in the future. Using patient-derived samples in pre-clinical work, researchers discovered that by combining two therapeutic agents they could nudge TNBC cells into a more treatable state.

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New therapeutic strategy identified for triple negative breast cancer

Triple negative breast cancer (TNBC) remains the most aggressive and deadly type of breast cancer, but new findings from cancer researchers are pointing the way toward therapeutic strategies that could be tested in clinical trials in the future. Using patient-derived samples in pre-clinical work, researchers discovered that by combining two therapeutic agents they could nudge TNBC cells into a more treatable state.

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Protein blocking bone development could hold clues for future osteoporosis treatment

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

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Keeping it together: How calcium signals help cells bury their dead neighbors

Dying cells are typically expelled from epithelial sheets to prevent foreign substances and microorganisms from entering, but the mechanism underlying this process is unclear. A recent study has revealed a calcium-mediated mechanism essential for surrounding cells to expel an adjacent dying cell. Their findings clarify various aspects of this intricate process, which could enhance our understanding of epithelial pathologies such as atopic dermatitis and inflammatory bowel disease.

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Common breast cancer treatments may speed aging process

Markers of cellular aging -- such as DNA damage response, cellular senescence, and inflammatory pathways -- significantly increased in all breast cancer survivors, regardless of the type of treatment received.

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Do people with MS have an increased risk of cancer?

A new study has found some cancers to be slightly more frequent in people with multiple sclerosis (MS) than in people without MS. Types of cancers found to have a small increased risk include bladder, brain and cervical cancers. The study does not prove that MS increases a person's risk of cancer. It only shows an association.

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Scientists discover that special immune cells stop metastatic cancer

Researchers have discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body.

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Scientist develops new model for ovarian cancer -- with crossover to uterine cancer

Researchers say that in the course of developing a new model for ovarian cancer, they've developed additional evidence that serous uterine cancer possibly begins in the fallopian tubes, not the uterus.

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Role of ophthalmic acid in motor function control

A research team has revealed that a molecule in the brain -- ophthalmic acid -- unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson's and other movement diseases.

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How estrogen's millisecond-fast action happens

Researchers discovered a mechanism by which estrogen can trigger fast neuronal responses.

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Estrogens play a hidden role in cancers, inhibiting a key immune cell

Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study unexpectedly finds that estrogens play a role in fueling the growth of breast cancers without the receptors, as well as numerous other cancers.

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Estrogens play a hidden role in cancers, inhibiting a key immune cell

Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study unexpectedly finds that estrogens play a role in fueling the growth of breast cancers without the receptors, as well as numerous other cancers.

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AI could predict breast cancer risk via 'zombie cells'

Women worldwide could see better treatment with new AI technology which enables better detection of damaged cells and more precisely predict the risk of getting breast cancer, shows new research.

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AI could predict breast cancer risk via 'zombie cells'

Women worldwide could see better treatment with new AI technology which enables better detection of damaged cells and more precisely predict the risk of getting breast cancer, shows new research.

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New cancer diagnoses did not rebound as expected following pandemic

Cancer incidence trends in 2021 largely returned to what they were before the COVID-19 pandemic, according to a study by researchers at the National Institutes of Health (NIH). However, there was little evidence of a rebound in incidence that would account for the decline in diagnoses in 2020, when screening and other medical care was disrupted. One exception was breast cancer, where the researchers did see an uptick in diagnoses of advanced-stage disease in 2021.

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New cancer diagnoses did not rebound as expected following pandemic

Cancer incidence trends in 2021 largely returned to what they were before the COVID-19 pandemic, according to a study by researchers at the National Institutes of Health (NIH). However, there was little evidence of a rebound in incidence that would account for the decline in diagnoses in 2020, when screening and other medical care was disrupted. One exception was breast cancer, where the researchers did see an uptick in diagnoses of advanced-stage disease in 2021.

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Breast and ovarian cancer newly linked to thousands of gene variants

New research identifies specific genetic changes that can increase a person's risk of breast and ovarian cancers, to help guide clinical decision-making.

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Metal exposure can increase cardiovascular disease risk

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors, according to a new study. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

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Ten-year study shows tomosynthesis improves breast cancer detection

According to a new 10-year study, screening for breast cancer with digital breast tomosynthesis (DBT) increases cancer detection rates and significantly reduces the rate of advanced cancers compared to conventional 2D digital mammography.

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New treatment extends ovarian function in older mice

Scientists have discovered a novel way to lengthen the 'healthspan' of a women's ovaries -- improving maintenance of the ovaries and preventing key age-related changes in ovarian function. 'Healthspan' refers to the length of time a person remains healthy and free from serious illness or chronic diseases.

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Tumor-induced B cell changes reveal potential biomarker for treatment response in triple negative breast cancer

Researchers have discovered new insights into tumor-induced B cell changes in blood and bone marrow of triple negative breast cancer patients. The findings show two distinct patterns of B cell abnormalities that could serve as blood biomarkers for determining likelihood of response to standard-of-care chemotherapy and immunotherapy.

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Antibody-drug conjugate found effective against brain metastases in patients with HER2-positive breast cancer

A drug that delivers chemotherapy directly to tumors has shown impressive activity against some of the hardest-to-reach cancer cells: those that have spread to the brain in patients with advanced HER2-positive breast cancer. The findings, from an international clinical trial, reinforce earlier findings of the benefits of the drug -- trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate -- in these patients, trial leaders say.

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New proteins involved in regulating the cell membrane

Scientists have uncovered new details about how cells manage the distribution of lipids in their cell membrane. These lipids, known as phospholipids, are arranged in a bilayer of membranes, regulating entry and exit of certain molecules to maintain a stable internal environment.

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Genes with strong impact on menopause timing also link to cancer risk

The team first looked at variation in data from genetic sequencing of 106,973 post-menopausal female participants in the UK Biobank study. Researchers focused on rare types of genetic changes which cause a loss of the protein, and investigated their effect on the timing of menopause. The genetic changes studied are all rare in the population, however their influence on menopause is five times greater than the impact of any previously identified common genetic variant.

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Novel bone cancer therapy has 99% success rate, tests show

Bioactive glasses, a filling material which can bond to tissue and improve the strength of bones and teeth, has been combined with gallium to create a potential treatment for bone cancer. Tests in labs have found that bioactive glasses doped with the metal have a 99 percent success rate of eliminating cancerous cells and can even regenerate diseased bones.

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Low-impact yoga and exercise found to help older women manage urinary incontinence

New research finds that 12 weeks of low-impact exercise classes reduced daily episodes of urinary incontinence by more than half.

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Skin fungus colonization accelerates breast cancer tumor growth

A new study shows that skin fungus colonization of Malassezia globosa speeds up breast cancer tumor growth.

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Skin fungus colonization accelerates breast cancer tumor growth

A new study shows that skin fungus colonization of Malassezia globosa speeds up breast cancer tumor growth.

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False-positive mammograms discourage some women from future screenings

A false-positive mammogram may deter women from future screenings, according to a new study. But staying on schedule remains key to early detection of cancer.

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False-positive mammograms discourage some women from future screenings

A false-positive mammogram may deter women from future screenings, according to a new study. But staying on schedule remains key to early detection of cancer.

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Billions worldwide consume inadequate levels of micronutrients critical to human health

More than half of the global population consumes inadequate levels of several micronutrients essential to health, including calcium, iron, and vitamins C and E, according to a new study. It is the first study to provide global estimates of inadequate consumption of 15 micronutrients critical to human health.

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New study supports annual breast cancer screening for women over 40

Women diagnosed with breast cancer who had regular screening mammograms every year were less likely to have late-stage cancer and had higher overall survival than those who received screening every other year or less often, according to new research.

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New study supports annual breast cancer screening for women over 40

Women diagnosed with breast cancer who had regular screening mammograms every year were less likely to have late-stage cancer and had higher overall survival than those who received screening every other year or less often, according to new research.

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Key discovery advances fight to reduce breast cancer recurrence

The surprising discovery that cellular protein G 13 may actually protect against -- rather than promote growth of -- the most commonly relapsing type of breast cancer signals potential for more effective and innovative treatments.

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Key discovery advances fight to reduce breast cancer recurrence

The surprising discovery that cellular protein G 13 may actually protect against -- rather than promote growth of -- the most commonly relapsing type of breast cancer signals potential for more effective and innovative treatments.

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When is the best time of day for cancer treatment?

How effective medications are depends on various factors, including the time of day when they are administered. Why? Because our bodies don't always function exactly the same. Instead, they follow the cycle set by their internal clock, otherwise known as circadian rhythm. But since each person's circadian rhythm is different and depends on a number of different factors, it is difficult to tailor medication schedules to an individual patient's body clock. Researchers have now developed a method for determining the optimum time of cancer treatment based on certain breast cancer cell lines.

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Rates of obesity-related cancer are rising sharply in young Chinese people

Obesity-related cancer rates in China were rising at an alarming 3.6% every year between 2007 and 2021 while non-obesity-related cancers remained stable, according to the first comprehensive study. The increase is particularly pronounced among young people, highlighting the urgent need for better public health policies to address China's growing overweight and obesity rates.

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Hot flash drug shows significant, rapid benefits in pivotal clinical trials

The investigational drug elinzanetant reduces hot flashes while improving women's sleep and quality of life, new research finds.

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Higher thiazide doses shown to reduce kidney stone events

Higher thiazide doses are associated with greater reductions in urine calcium, which in turn correlate with fewer symptomatic kidney stone events, according to a new study.

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